Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands

Autor: Srijana Upadhyay, Amanuel Esayas Hailemariam, Fuada Mariyam, Zahin Hafiz, Gregory Martin, Jainish Kothari, Evan Farkas, Gargi Sivaram, Logan Bell, Ronald Tjalkens, Stephen Safe

Publikováno v: Biomolecules, Vol 14, Iss 3, p 284 (2024)

Bis-indole derived compounds such as 1,1-bis(3′-indolyl)-1-(3,5-disubstitutedphenyl) methane (DIM-3,5) and the corresponding 4-hydroxyl analogs (DIM8-3,5) are NR4A1 ligands that act as inverse NR4A1 agonists and are potent inhibitors of tumor growt

Externí odkaz: https://doaj.org/article/c600864d081d4f5ba321b97daaa1bfef

Demonstrating dynamic surface codes

Autor: Eickbusch, Alec, McEwen, Matt, Sivak, Volodymyr, Bourassa, Alexandre, Atalaya, Juan, Claes, Jahan, Kafri, Dvir, Gidney, Craig, Warren, Christopher W., Gross, Jonathan, Opremcak, Alex, Miao, Nicholas Zobrist Kevin C., Roberts, Gabrielle, Satzinger, Kevin J., Bengtsson, Andreas, Neeley, Matthew, Livingston, William P., Greene, Alex, Rajeev, Acharya, Beni, Laleh Aghababaie, Aigeldinger, Georg, Alcaraz, Ross, Andersen, Trond I., Ansmann, Markus, Frank, Arute, Arya, Kunal, Asfaw, Abraham, Babbush, Ryan, Ballard, Brian, Bardin, Joseph C., Bilmes, Alexander, Jenna, Bovaird, Bowers, Dylan, Brill, Leon, Broughton, Michael, Browne, David A., Buchea, Brett, Buckley, Bob B., Tim, Burger, Burkett, Brian, Bushnell, Nicholas, Cabrera, Anthony, Campero, Juan, Chang, Hung-Shen, Chiaro, Ben, Chih, Liang-Ying, Cleland, Agnetta Y., Cogan, Josh, Collins, Roberto, Conner, Paul, Courtney, William, Alexander, Crook, L., Curtin, Ben, Das, Sayan, Barba, Alexander Del Toro, Demura, Sean, De Lorenzo, Laura, Di Paolo, Agustin, Donohoe, Paul, Drozdov, Ilya K., Dunsworth, Andrew, Elbag, Aviv Moshe, Elzouka, Mahmoud, Erickson, Catherine, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Ganjam, Suhas, Gonzalo, Garcia, Gasca, Robert, Genois, Élie, Giang, William, Gilboa, Dar, Gosula, Raja, Dau, Alejandro Grajales, Dietrich, Graumann, Ha, Tan, Habegger, Steve, Hansen, Monica, Harrigan, Matthew P., Harrington, Sean D., Heslin, Stephen, Heu, Paula, Higgott, Oscar, Hiltermann, Reno, Hilton, Jeremy, Huang, Hsin-Yuan, Huff, Ashley, Huggins, William J., Jeffrey, Evan, Jiang, Zhang, Jin, Xiaoxuan, Jones, Cody, Joshi, Chaitali, Juhas, Pavol, Kabel, Andreas, Kang, Hui, Amir, Karamlou, H., Kechedzhi, Kostyantyn, Khaire, Trupti, Khattar, Tanuj, Khezri, Mostafa, Kim, Seon, Kobrin, Bryce, Korotkov, Alexander N., Kostritsa, Fedor, Kreikebaum, John Mark, Kurilovich, Vladislav D., Landhuis, David, Tiano, Lange-Dei, Langley, Brandon W., Lau, Kim-Ming, Ledford, Justin, Lee, Kenny, Lester, Brian J., Guevel, Loïck Le, Wing, Li, Yan, Lill, Alexander T., Locharla, Aditya, Lucero, Erik, Lundahl, Daniel, Lunt, Aaron, Madhuk, Sid, Maloney, Ashley, Mandrà, Salvatore, Martin, Leigh S., Martin, Orion, Maxfield, Cameron, McClean, Jarrod R., Meeks, Seneca, Anthony, Megrant, Molavi, Reza, Molina, Sebastian, Montazeri, Shirin, Movassagh, Ramis, Newman, Michael, Nguyen, Anthony, Nguyen, Murray, Ni, Chia-Hung, Oas, Logan, Orosco, Raymond, Ottosson, Kristoffer, Pizzuto, Alex, Potter, Rebecca, Pritchard, Orion, Quintana, Chris, Ramachandran, Ganesh, Reagor, Matthew J., Rhodes, David M., Rosenberg, Eliott, Rossi, Elizabeth, Sankaragomathi, Kannan, Schurkus, Henry F., Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Small, Spencer, Smith, W. Clarke, Springer, Sofia, Sterling, George, Suchard, Jordan, Szasz, Aaron, Sztein, Alex, Thor, Douglas, Tomita, Eifu, Torres, Alfredo, Torunbalci, M. Mert, Vaishnav, Abeer, Vargas, Justin, Sergey, Vdovichev, Vidal, Guifre, Heidweiller, Catherine Vollgraff, Waltman, Steven, Waltz, Jonathan, Wang, Shannon X., Ware, Brayden, Weidel, Travis, White, Theodore, Wong, Kristi, Woo, Bryan W. K., Woodson, Maddy, Xing, Cheng, Yao, Z. Jamie, Yeh, Ping, Ying, Bicheng, Yoo, Juhwan, Yosri, Noureldin, Young, Grayson, Zalcman, Adam, Yaxing, Zhang, Zhu, Ningfeng, Boixo, Sergio, Kelly, Julian, Smelyanskiy, Vadim, Neven, Hartmut, Bacon, Dave, Chen, Zijun, Klimov, Paul V., Roushan, Pedram, Neill, Charles, Chen, Yu, Morvan, Alexis

A remarkable characteristic of quantum computing is the potential for reliable computation despite faulty qubits. This can be achieved through quantum error correction, which is typically implemented by repeatedly applying static syndrome checks, per

Externí odkaz: http://arxiv.org/abs/2412.14360

A bibliometric analysis and scoping study to identify English-language perspectives on slums

Autor: Henn, Katharina, Lestakova, Michaela, Logan, Kevin, Hartig, Jakob, Georganos, Stefanos, Friesen, John

Slums, informal settlements, and deprived areas are urban regions characterized by poverty. According to the United Nations, over one billion people reside in these areas, and this number is projected to increase. Additionally, these settlements are

Externí odkaz: http://arxiv.org/abs/2412.13689

A Long-Duration Autonomy Approach to Connected and Automated Vehicles

Autor: Beaver, Logan E.

In this article, we present a long-duration autonomy approach for the control of connected and automated vehicles (CAVs) operating in a transportation network. In particular, we focus on the performance of CAVs at traffic bottlenecks, including round

Externí odkaz: http://arxiv.org/abs/2412.11804

Emulating the Global Change Analysis Model with Deep Learning

Autor: Holmes, Andrew, Jensen, Matt, Coffland, Sarah, Shen, Hidemi Mitani, Sizemore, Logan, Bassetti, Seth, Nieva, Brenna, Tebaldi, Claudia, Snyder, Abigail, Hutchinson, Brian

The Global Change Analysis Model (GCAM) simulates complex interactions between the coupled Earth and human systems, providing valuable insights into the co-evolution of land, water, and energy sectors under different future scenarios. Understanding t

Externí odkaz: http://arxiv.org/abs/2412.08850