Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Logan A, Combee"'
Publikováno v:
ACS Med Chem Lett
[Image: see text] Many promising drug candidates and pharmaceutical compounds fail due to idiosyncratic adverse drug reactions (IADRs), often arising from the formation of reactive metabolites. Among the “structural alerts” responsible, anilines
Publikováno v:
Organic Letters. 21:2307-2311
Formal [5+1] cycloadditions between aryl-substituted vinylcyclopropanes and nitrenoid precursors are reported. The method, which employs Rh(2)(esp)(2) as a catalyst, leads to the highly regioselective formation of substituted tetrahydropyridines. Pre
Publikováno v:
Synlett. 29:2331-2336
Predictably site-selective catalytic methods for intermolecular C(sp3)–H hydroxylation and amination hold great promise for the synthesis and late-stage modification of complex molecules. Transition-metal catalysis has been the most common approach
Publikováno v:
Chemical Science. 9:935-939
This report details the first organocatalytic method for nitrenoid transfer and its application to intermolecular, site-selective C(sp3)–H amination. The method utilizes a trifluoromethyl iminium salt as the catalyst, iminoiodinanes as the nitrogen
Publikováno v:
Organicbiomolecular chemistry. 17(43)
Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. This represents the second example of a [5 + 1] n
Publikováno v:
European Journal of Organic Chemistry. 2016:3335-3338
Described are the first examples of intermolecular electrophilic additions of epoxides to alkenes, which proceed through a classic cationic mechanism initiated by epoxide C–O bond cleavage. Treatment of styrene oxides and either styrenes or dienes
Publikováno v:
Chemical Science
This report details the first organocatalytic method for nitrenoid transfer and its application to intermolecular, site-selective C(sp3)–H amination.
This report details the first organocatalytic method for nitrenoid transfer and its applicati
This report details the first organocatalytic method for nitrenoid transfer and its applicati
Autor:
W. Dean Harman, Logan A. Combee, Katy B. Wilson, Michal Sabat, Jeffery T. Myers, Hannah S. Nedzbala
Publikováno v:
Journal of the American Chemical Society. 139(33)
The effects of an electron-withdrawing group on the organic chemistry of an η2-bound benzene ring are explored using the complex TpW(NO)(PMe3)(η2-PhCF3). This trifluorotoluene complex was found to undergo a highly regio- and stereoselective 1,2-add
Publikováno v:
ChemInform. 47
Described are the first examples of intermolecular electrophilic additions of epoxides to alkenes, which proceed through a classic cationic mechanism initiated by epoxide C–O bond cleavage. Treatment of styrene oxides and either styrenes or dienes