Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Loewe Additivity"'
The many dimensions of combination therapy: How to combine antibiotics to limit resistance evolution
Publikováno v:
Evolutionary Applications, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract In combination therapy, bacteria are challenged with two or more antibiotics simultaneously. Ideally, separate mutations are required to adapt to each of them, which is a priori expected to hinder the evolution of full resistance. Yet, the s
Externí odkaz:
https://doaj.org/article/f230c9086a0e466d87373a7f0f500e10
Akademický článek
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Autor:
Joseph Meletiadis, David R. Andes, Shawn R. Lockhart, Mahmoud A. Ghannoum, Cindy C. Knapp, Luis Ostrosky-Zeichner, Michael A. Pfaller, Vishnu Chaturvedi, Thomas J. Walsh
Publikováno v:
Journal of Fungi, Vol 8, Iss 9, p 967 (2022)
Combination antifungal therapy is widely used but not well understood. We analyzed the spectrophotometric readings from a multicenter study conducted by the New York State Department of Health to further characterize the in vitro interactions of the
Externí odkaz:
https://doaj.org/article/ad3d59ee98f34271bd5930d1d702fd84
Autor:
Lee, J. Jack
Publikováno v:
Biometrics, 2006 Dec 01. 62(4), 986-995.
Externí odkaz:
https://www.jstor.org/stable/4124519
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
In synergy studies, one focuses on compound combinations that promise a synergistic or antagonistic effect. With the help of high-throughput techniques, a huge amount of compound combinations can be screened and filtered for suitable candidates for a
Externí odkaz:
https://doaj.org/article/7e4fc673f3d443f39df7f8a945c8525b
Publikováno v:
Toxins, Vol 12, Iss 3, p 153 (2020)
In the past decades, many studies have examined the nature of the interaction between mycotoxins in biological models classifying interaction effects as antagonisms, additive effects, or synergisms based on a comparison of the observed effect with th
Externí odkaz:
https://doaj.org/article/b8baa0788bb047e8a20b81087c45b979
Autor:
Gilles Guillot, Alina Macacu
Publikováno v:
Toxicology Letters. 325:62-66
Risk assessment for mixtures of chemicals requires to investigate the magnitude of their potential adverse effects on living organisms. This is usually done by assessing how experimental toxicological mixture data depart from the model of Loewe addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae9461654038962b426451987e86a77
https://doi.org/10.1016/j.toxlet.2020.02.005
https://doi.org/10.1016/j.toxlet.2020.02.005
Publikováno v:
Trends Pharmacol Sci
Even as the clinical impact of drug combinations continues to accelerate, no consensus on how to quantify drug synergy has emerged. Rather, surveying the landscape of drug synergy reveals the persistence of historical fissures regarding the appropria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81e95b3832433cc9de5dcfa32b90b4e
https://doi.org/10.1016/j.tips.2020.01.011
https://doi.org/10.1016/j.tips.2020.01.011
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Multi-drug combination therapy carries significant promise for pharmacological intervention, primarily better efficacy with less toxicity and fewer side effects. However, the field lacks methodology to assess synergistic or antagonistic interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b6f9264175725611344fef22f44065
https://www.frontiersin.org/articles/10.3389/fphar.2021.686201/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.686201/full
Autor:
Soo-il Lee
Publikováno v:
Korean Journal of Anesthesiology, Vol 58, Iss 5, Pp 421-434 (2010)
Anesthesiologists have been aware of the importance of optimal drug combination long ago and performed many investigations about the combined use of anesthetic agents. There are 3 classes of drug interaction: additive, synergistic, and antagonistic.
Externí odkaz:
https://doaj.org/article/29a12b0000994830b7f52f3d787b1cea