Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor.

Autor: Elsenoor J Klaver, Loes M Kuijk, Thisbe K Lindhorst, Richard D Cummings, Irma van Die

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124089 (2015)

Schistosomiasis is a common debilitating human parasitic disease in (sub)tropical areas, however, schistosome infections can also protect against a variety of inflammatory diseases. This has raised broad interest in the mechanisms by which Schistosom

Externí odkaz: https://doaj.org/article/e4e8f0a897d24eb2a66b00ef8144031c

Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor

Autor: Thisbe K. Lindhorst, Irma van Die, Elsenoor J. Klaver, Richard D. Cummings, Loes M. Kuijk

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0124089 (2015)
PLoS ONE, 10(4):e0124089. Public Library of Science
Klaver, E J, Kuijk, L M, Lindhorst, T K, Cummings, R D & van Die, I 2015, ' Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor ', PLoS ONE, vol. 10, no. 4, e0124089 . https://doi.org/10.1371/journal.pone.0124089

Schistosomiasis is a common debilitating human parasitic disease in (sub)tropical areas, however, schistosome infections can also protect against a variety of inflammatory diseases. This has raised broad interest in the mechanisms by which Schistosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d713feaa800e99c84d3bd02242a8675d
https://doi.org/10.1371/journal.pone.0124089

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation

Autor: Helene Kringel, Georg Kraal, Elsenoor J. Klaver, Elena Pinelli, Helga E. de Vries, Gerd Bouma, Gijs Kooij, Christine D. Dijkstra, Sven C. M. Bruijns, Priscilla D. A. M. Heijnen, Loes M. Kuijk, Susanne M. A. van der Pol, Irma van Die

Publikováno v: Molecular Immunology, 51(2), 210-218. Elsevier Limited
Kuijk, L M, Klaver, E J, Kooij, G, van der Pol, S M A, Heijnen, P, Bruijns, S C M, Kringel, H, Pinelli, E, Kraal, G, de Vries, H E, Dijkstra, C D, Bouma, G & van Die, I M 2012, ' Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation ', Molecular Immunology, vol. 51, no. 2, pp. 210-218 . https://doi.org/10.1016/j.molimm.2012.03.020

The increased incidence of auto-inflammatory and autoimmune diseases in the developed countries seems to be caused by an imbalance of the immune system due to the lack of proper regulation. Helminth parasites are well known modulators of the immune s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebb58f31b619f8da48b35cecd984bf2
https://research.vumc.nl/en/publications/e4b6eeaf-8270-4649-802a-5cc2291f9a4c

12.2 Mevalonate kinase deficiency: Impaired isoprenoid synthesis induces IL-1beta production via activation of Rac1

Autor: Paul J. Coffer, Loes M. Kuijk, Joost Frenkel, Hans R. Waterham, Janet Koster

Publikováno v: Pediatric Rheumatology Online Journal, Vol 6, Iss Suppl 1, p S24 (2008)
Pediatric Rheumatology Online Journal

Mevalonate kinase deficiency is an autosomal recessive disorder characterized by recurring episodes of fever and inflammation. Peripheral blood mononuclear cells from mevalonate kinase deficiency patients secrete high levels of IL-1β when stimulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b94381db91405af3a2da7ef9f7bf422
https://doi.org/10.1186/1546-0096-6-s1-s24

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

Autor: Fabio Martinon, Jürg Tschopp, Robin van Bruggen, Loes M. Kuijk, Helen Everett, Roel Broekhuizen, J. Alain Kummer, Laetitia Agostini

Publikováno v: journal of histochemistry and cytochemistry, 55(5), 443-452. Histochemical Society Inc.

Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to inflammasomes that activate caspase-1, resulting in the processing of proinflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea72437f78e9baa65cc6476449cef6c
https://pure.amc.nl/en/publications/inflammasome-components-nalp-1-and-3-show-distinct-but-separate-expression-profiles-in-human-tissues-suggesting-a-sitespecific-role-in-the-inflammatory-response(1ee8fa64-c101-4309-95e4-cc35de3a80c1).html