Výsledky vyhledávání - "Loes J. Drenth-Diephuis"

UTF1 is a chromatin-associated protein involved in ES cell differentiation

Autor: Issei Komuro, Susanne M. Kooistra, Loes J. Drenth-Diephuis, Vincent van den Boom, Jeroen Essers, Bart J. L. Eggen, Adriaan B. Houtsmuller, Koshiro Monzen, Marije Boesjes, Bart Geverts

Publikováno v: Journal of Cell Biology, 178(6), 913-924. ROCKEFELLER UNIV PRESS
Journal of Cell Biology, 178(6), 913-924. Rockefeller University Press
The Journal of Cell Biology

Embryonic stem (ES) cells are able to grow indefinitely (self-renewal) and have the potential to differentiate into all adult cell types (pluripotency). The regulatory network that controls pluripotency is well characterized, whereas the molecular ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b464ff48e5cd5195b8342bb76301c4f6
https://doi.org/10.1083/jcb.200702058

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Cellular effects of imatinib on medullary thyroid cancer cells, harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations

Autor: I. Plaza de Menacho, J.Th.M. Plukker, T. P. Links, Bart J. L. Eggen, Loes J. Drenth-Diephuis, Jan Osinga, J. W. B. de Groot, Robert M.W. Hofstra, Hein Schepers

Publikováno v: Surgery, 139(6), 806-814. MOSBY-ELSEVIER

Background Activating mutations in the RET gene, which encodes a tyrosine kinase receptor, often cause medullary thyroid carcinoma (MTC). Surgical resection is the only curative treatment; no effective systemic treatment is available. We evaluated im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48e90513f76bdec44be6e9800be976a
https://doi.org/10.1016/j.surg.2005.10.019

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Constitutive GFP-UTF1 Expression Interferes with ES and EC Cell Differentiation

Autor: Bart J. L. Eggen, Loes J. Drenth-Diephuis, Rajkumar P. Thummer

Publikováno v: Journal of Stem Cell Research & Therapy.

Embryonic stem cells have the ability to self-renew and can differentiate into all cell types of the three embryonic germ lineages. The undifferentiated embryonic cell Transcription Factor 1 (UTF1) gene is highly expressed in ES cells and we previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc158f37c139819e4210d889963534dd
https://doi.org/10.4172/2157-7633.1000127

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Functional characterization of single-nucleotide polymorphisms in the human undifferentiated embryonic-cell transcription factor 1 gene

Autor: Loes J. Drenth-Diephuis, Bart J. L. Eggen, Rajkumar P. Thummer, Karen E. Carney

Publikováno v: Dna and cell biology, 29(5), 241-248

Single-nucleotide polymorphisms (SNPs) are single-nucleotide sequence variations between individuals. Two missense SNPs are present in the human undifferentiated embryonic-cell transcription factor 1 (UTF1) gene and their consequences for UTF1 functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ac9594801ad9afcea40559f57535cc
https://pubmed.ncbi.nlm.nih.gov/20218897

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Inhibition of the Transforming Growth Factor β (TGFβ) Pathway by Interleukin-1β Is Mediated through TGFβ-activated Kinase 1 Phosphorylation of SMAD3

Autor: Ariëtte M. van Bennekum, Loes J. Drenth-Diephuis, Bart J. L. Eggen, David J.J. de Gorter, Jan Jacob Schuringa, Albertus T. J. Wierenga, Edo Vellenga, Germaine F.J.D. Benus

Publikováno v: Molecular Biology of the Cell, 16(8), 3501-3510. AMER SOC CELL BIOLOGY

Transforming growth factor beta is the prototype of a large family of secreted factors that regulate multiple biological processes. In the immune system, TGFbeta acts as an anti-inflammatory and immunosuppressive molecule, whereas the cytokine interl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3342472d32838fdc10ad22acd0c12f26
https://europepmc.org/articles/PMC1182292/

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