A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions.

Autor: Kovar C; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Loer HLH; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Rüdesheim S; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Fuhr LM; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Marok FZ; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Selzer D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology, and Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180), Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Jul; Vol. 13 (7), pp. 1144-1159. Date of Electronic Publication: 2024 May 01.

Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug-drug-gene interaction network.

Autor: Feick D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Rüdesheim S; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany., Marok FZ; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Selzer D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Loer HLH; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Teutonico D; Translational Medicine & Early Development, Sanofi-Aventis R&D, Chilly-Mazarin, France., Frechen S; Bayer AG, Pharmaceuticals, Research & Development, Systems Pharmacology & Medicine, Leverkusen, Germany., van der Lee M; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Moes DJAR; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Swen JJ; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Aug; Vol. 12 (8), pp. 1143-1156. Date of Electronic Publication: 2023 May 23.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug-Drug-Gene Interaction Predictions.

Autor: Loer HLH; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Türk D; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Gómez-Mantilla JD; Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, 55216 Ingelheim, Germany., Selzer D; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Lehr T; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Apr 22; Vol. 14 (5). Date of Electronic Publication: 2022 Apr 22.