Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Loek D Loozen"'
Autor:
Loek D Loozen, Moyo C Kruyt, Angela H M Kragten, Ted Schoenfeldt, Michiel Croes, Cumhur F Oner, Wouter J A Dhert, Jacqueline Alblas
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220028 (2019)
To induce osteogenicity in bone graft substitutes, plasmid-based expression of BMP-2 (pBMP-2) has been successfully applied in gene activated matrices based on alginate polymer constructs. Here, we investigated whether cell seeding is necessary for n
Externí odkaz:
https://doaj.org/article/38a87dd9cb1f4ad0a39b741dc26e9f86
Publikováno v:
Journal of materials chemistry. B. 1(48)
A well-known osteogenic agent in the field of regenerative medicine is bone morphogenetic protein-2 (BMP-2). Non-viral delivery of a plasmid containing the gene encoding BMP-2 has shown to induce bone formation in vivo. In order to develop gene activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d89fab2c81034da82c26e6193c3b82
https://pubmed.ncbi.nlm.nih.gov/32261270
https://pubmed.ncbi.nlm.nih.gov/32261270
Autor:
Loek D. Loozen, F. C. Oner, A. Vandersteen, M. C. Kruyt, Jacqueline Alblas, Wouter J.A. Dhert, Angela H.M. Kragten
Publikováno v:
European Cells and Materials, 35, 195. Swiss Society for Biomaterials
European Cells & Materials, Vol 35, Pp 195-208 (2018)
European Cells & Materials, Vol 35, Pp 195-208 (2018)
Non-viral gene delivery is a safe technique to release sustained physiologic dosages of bone morphogenetic protein (BMP). Co-delivery of multiple BMPs can result in the formation of more potent BMP heterodimers. In this study, non-viral co-delivery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d97dca43ab8d43ddf68bd0ceab5ed3
https://doi.org/10.22203/ecm.v035a14
https://doi.org/10.22203/ecm.v035a14
Autor:
Diederik H.R. Kempen, Michael J. Yaszemski, Marianna A. Tryfonidou, Björn P. Meij, Lichun Lu, Jacqueline Alblas, Loek D. Loozen, Behdad Pouran, Wouter J.A. Dhert, Maurits Geert Laurent Olthof
Publikováno v:
Tissue Engineering-Part A, 25(3-4), 193. Mary Ann Liebert Inc.
The main challenge in bone morphogenic protein 2 (BMP-2)-based application lies in finding strategies that prolong its effective period as it has a short biological half-life. Several BMP-2 release profiles have shown to enhance bone formation at var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e9932851808792bd2b1b0acfc127b6
https://dspace.library.uu.nl/handle/1874/385587
https://dspace.library.uu.nl/handle/1874/385587
Autor:
Michiel Croes, Cumhur Oner, Jacqueline Alblas, Loek D. Loozen, Angela H.M. Kragten, Wouter J.A. Dhert, Moyo C. Kruyt, Ted Schoenfeldt
Publikováno v:
PLoS ONE, 14(7). Public Library of Science
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0220028 (2019)
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0220028 (2019)
To induce osteogenicity in bone graft substitutes, plasmid-based expression of BMP-2 (pBMP-2) has been successfully applied in gene activated matrices based on alginate polymer constructs. Here, we investigated whether cell seeding is necessary for n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1339c3cfe2ad9e4792c26a45ffbd60
https://hdl.handle.net/1874/385985
https://hdl.handle.net/1874/385985
Autor:
Yvonne J.M van der Helm, Moyo C. Kruyt, Loek D. Loozen, F. Cumhur Oner, Wouter J.A. Dhert, Jacqueline Alblas
Publikováno v:
Tissue Engineering. Part A, 21(9-10), 1672. Mary Ann Liebert Inc.
Treatment and reconstruction of large bone defects, delayed unions, and nonunions is challenging and has resulted in an ongoing search for novel tissue-engineered therapies. Bone morphogenetic protein-2 (BMP-2) gene therapy is a promising strategy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9df448b11a63f3de258994459ec82c
https://doi.org/10.1089/ten.tea.2014.0593
https://doi.org/10.1089/ten.tea.2014.0593
Autor:
Angela Vandersteen, Loek D. Loozen, Jacqueline Alblas, F. Cumhur Oner, Angela H.M. Kragten, Moyo C. Kruyt, Michiel Croes
Publikováno v:
Tissue Engineering-Part A, 24(19-20), 1423. Mary Ann Liebert Inc.
Ex vivo nonviral gene delivery of bone inductive factors has the potential to heal bone defects. Due to their inherent role in new bone formation, multipotent stromal cells (MSCs) have been studied as the primary target cell for gene delivery in a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3e9ea5353bd0759a97257b7613141a
https://hdl.handle.net/1874/372150
https://hdl.handle.net/1874/372150