Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Autor: Li, Chen, Stoma, Svetlana, Lotta, Luca A., Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P., Broer, Linda, Buxton, Jessica L., Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O., Gordon, Scott D., Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K., Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, van der Spek, Ashley, Verhoeven, Josine E., Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I., Canzian, Federico, Hamby, Stephen E., Hottenga, Jouke-Jan, Jones, Peter D., Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E., Montgomery, Grant W., Nyholt, Dale R., Perola, Markus, Pietiläinen, Kirsi H., Salomaa, Veikko, Sillanpää, Elina, Suchiman, H. Eka, van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I., Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul, Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hägg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G., Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N. Charlotte, Nilsson, Peter, Ong, Ken K., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L., Penninx, Brenda W.J. H., Quirós, J. Ramón, Jarvelin, Marjo Riitta, Rodríguez-Barranco, Miguel, Scott, Robert A., Severi, Gianluca, Slagboom, P. Eline, Spector, Tim D., Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G., van der Schouw, Yvonne T., van Duijn, Cornelia M., Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S., Danesh, John, Samani, Nilesh J., Wareham, Nicholas J., Nelson, Christopher P., Langenberg, Claudia, Codd, Veryan

Publikováno v: In The American Journal of Human Genetics 5 March 2020 106(3):389-404

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Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Autor: Li, Chen, Stoma, Svetlana, Lotta, Luca A, Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P, Broer, Linda, Buxton, Jessica L, Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O, Gordon, Scott D, Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K, Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, Van Der Spek, Ashley, Verhoeven, Josine E, Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I, Canzian, Federico, Hamby, Stephen E, Hottenga, Jouke-Jan, Jones, Peter D, Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E, Montgomery, Grant W, Nyholt, Dale R, Perola, Markus, Pietiläinen, Kirsi H, Salomaa, Veikko, Sillanpää, Elina, Suchiman, H Eka, Van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I, Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul, Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hägg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G, Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N Charlotte, Nilsson, Peter, Ong, Ken K, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L, Penninx, Brenda WJH, Quirós, J Ramón, Jarvelin, Marjo Riitta, Rodríguez-Barranco, Miguel, Scott, Robert A, Severi, Gianluca, Slagboom, P Eline, Spector, Tim D, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G, Van Der Schouw, Yvonne T, Van Duijn, Cornelia M, Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S, Danesh, John, Samani, Nilesh J, Wareham, Nicholas J, Nelson, Christopher P, Langenberg, Claudia, Codd, Veryan

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including

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