Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Lodewyk Wessels"'
Autor:
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly r
Externí odkaz:
https://doaj.org/article/07f7321be51a4bf993332239abb08b2b
Autor:
Sofía Ibáñez-Molero, Alex van Vliet, Joanna Pozniak, Karlijn Hummelink, Alexandra M. Terry, Kim Monkhorst, Joyce Sanders, Ingrid Hofland, Ewout Landeloos, Yannick Van Herck, Oliver Bechter, Thomas Kuilman, Weiwei Zhong, Jean-Christophe Marine, Lodewyk Wessels, Daniel S. Peeper
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Immunotherapies, in particular immune checkpoint blockade (ICB), have improved the clinical outcome of cancer patients, although many fail to mount a durable response. Several resistance mechanisms have been identified, but our understanding of the r
Externí odkaz:
https://doaj.org/article/cf4c583ffddb4dc1aa5667545d3848df
Autor:
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Externí odkaz:
https://doaj.org/article/56b5db94e7bb424f9f026fc02defd139
Autor:
Tomasz Ahrends, Julia Busselaar, Tesa M. Severson, Nikolina Bąbała, Evert de Vries, Astrid Bovens, Lodewyk Wessels, Fred van Leeuwen, Jannie Borst
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recal
Externí odkaz:
https://doaj.org/article/5213f8fbacb34ae3ab044b7181b1b063
Autor:
Tesa M. Severson, Yongsoo Kim, Stacey E. P. Joosten, Karianne Schuurman, Petra van der Groep, Cathy B. Moelans, Natalie D. ter Hoeve, Quirine F. Manson, John W. Martens, Carolien H. M. van Deurzen, Ellis Barbe, Ingrid Hedenfalk, Peter Bult, Vincent T. H. B. M. Smit, Sabine C. Linn, Paul J. van Diest, Lodewyk Wessels, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of
Externí odkaz:
https://doaj.org/article/a437214d30c54971a83e6aa143ad69be
Autor:
Tesa M. Severson, Denise M. Wolf, Christina Yau, Justine Peeters, Diederik Wehkam, Philip C. Schouten, Suet-Feung Chin, Ian J. Majewski, Magali Michaut, Astrid Bosma, Bernard Pereira, Tycho Bismeijer, Lodewyk Wessels, Carlos Caldas, René Bernards, Iris M. Simon, Annuska M. Glas, Sabine Linn, Laura van ‘t Veer
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-9 (2017)
Abstract Background Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like tumors. We hypothe
Externí odkaz:
https://doaj.org/article/f9d39320e8404ffdb7196315ea5646b3
Autor:
Theodoros I. Roumeliotis, Steven P. Williams, Emanuel Gonçalves, Clara Alsinet, Martin Del Castillo Velasco-Herrera, Nanne Aben, Fatemeh Zamanzad Ghavidel, Magali Michaut, Michael Schubert, Stacey Price, James C. Wright, Lu Yu, Mi Yang, Rodrigo Dienstmann, Justin Guinney, Pedro Beltrao, Alvis Brazma, Mercedes Pardo, Oliver Stegle, David J. Adams, Lodewyk Wessels, Julio Saez-Rodriguez, Ultan McDermott, Jyoti S. Choudhary
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2201-2214 (2017)
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer cell lines a
Externí odkaz:
https://doaj.org/article/d6175c0cd7e54e1f86973be608f9900c
Autor:
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD
Externí odkaz:
https://doaj.org/article/bb08125c1aa14689b48e6b606c7f9587
Autor:
Mirjam C. Boelens, Micha Nethe, Sjoerd Klarenbeek, Julian R. de Ruiter, Eva Schut, Nicola Bonzanni, Amber L. Zeeman, Ellen Wientjens, Eline van der Burg, Lodewyk Wessels, Renée van Amerongen, Jos Jonkers
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2087-2101 (2016)
Invasive lobular carcinoma (ILC) is an aggressive breast cancer subtype with poor response to chemotherapy. Besides loss of E-cadherin, a hallmark of ILC, genetic inactivation of PTEN is frequently observed in patients. Through concomitant Cre-mediat
Externí odkaz:
https://doaj.org/article/d60d88237f8443e6ad63bec0763199eb
Autor:
Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K Sage, Sabarinath Vallath, John Le Quesne, David A Tice, Doraid Alrifai, Sylvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A Fennell, Mathew Garnett, Francesco Iorio, Lodewyk Wessels, Ultan McDermott, Samuel M Janes
Publikováno v:
eLife, Vol 7 (2018)
Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear de
Externí odkaz:
https://doaj.org/article/f8b56a1949f54101aa89a88d500f0a18