Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Lodewyk F.A. Wessels"'
Autor:
E.G. Engelhardt, R.S.J.M. Schmitz, M.A. Gerritsma, C.M.T. Sondermeijer, E. Verschuur, J.H.E. Houtzager, R. Griffioen, N. Bijker, R.M. Mann, V. Retèl, F.H. van Duijnhoven, J. Wesseling, E.M.A. Bleiker, Alastair Thompson, Serena Nik-Zainal, Elinor J. Sawyer, Helen Davies, Andrew Futreal, Nicholas Navin, E. Shelley Hwang, Jos Jonkers, Jacco van Rheenen, Fariba Behbod, Esther H. Lips, Marjanka Schmidt, Lodewyk F.A. Wessels, Daniel Rea, Proteeti Bhattacharjee, Hilary Stobart, Deborah Collyar, Donna Pinto, Marja van Oirsouw, S. Alaeikhanehshir, L. Elshof
Publikováno v:
Breast, Vol 77, Iss , Pp 103764- (2024)
Background: Ductal carcinoma in situ (DCIS) can progress to invasive breast cancer (IBC), but often never will. As we cannot predict accurately which DCIS-lesions will or will not progress to IBC, almost all women with DCIS undergo breast-conserving
Externí odkaz:
https://doaj.org/article/bc84270199394f7bb7028854a77ee924
Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial
Autor:
Mark Opdam, Annelot G.J. van Rossum, Marlous Hoogstraat, Gergana Bounova, Hugo M. Horlings, Erik van Werkhoven, Ingrid A.M. Mandjes, A. Elise van Leeuwen – Stok, Sander Canisius, Harm van Tinteren, Alex L.T. Imholz, Johanneke E.A. Portielje, Monique E.M.M. Bos, Sandra Bakker, Jelle Wesseling, Lennart Kester, Jacco van Rheenen, Emiel J. Rutgers, Renee X. de Menezes, Lodewyk F.A. Wessels, Marleen Kok, Hendrika M. Oosterkamp, Sabine C. Linn, Marcel Soesan, Rianne M. Oosterkamp, Frank Jeurissen, Nir Weijl, Karin J. Beelen, Aart van Bochove, Gerty de Klerk, Suzan Vrijaldenhoven, Annette van der Velden, Hiltje de Graaf, Marielle Smeets, Jetske Meerum Terwogt, Jolanda Schrama, Philomeen Kuijer, Hanneke Wilmink, Ronald Hoekstra, Judith Kroep, Hans F.M. Pruijt, Leander van Gerven, Allert H. Vos, Frans Erdkamp, Willemien G. van Leeuwen-Breuk, Alexander de Graeff
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110425- (2024)
Summary: The primary objective of the prospective, randomized, multicenter, phase 3 biomarker Microarray Analysis in breast cancer to Taylor Adjuvant Drugs Or Regimens trial (MATADOR: ISRCTN61893718) is to generate a gene expression profile that can
Externí odkaz:
https://doaj.org/article/3dae747c44804a5fafa1281b33a3c21c
Autor:
Jinhyuk Bhin, Mariana Paes Dias, Ewa Gogola, Frank Rolfs, Sander R. Piersma, Roebi de Bruijn, Julian R. de Ruiter, Bram van den Broek, Alexandra A. Duarte, Wendy Sol, Ingrid van der Heijden, Christina Andronikou, Taina S. Kaiponen, Lara Bakker, Cor Lieftink, Ben Morris, Roderick L. Beijersbergen, Marieke van de Ven, Connie R. Jimenez, Lodewyk F.A. Wessels, Sven Rottenberg, Jos Jonkers
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112538- (2023)
Summary: BRCA1 and BRCA2 both function in DNA double-strand break repair by homologous recombination (HR). Due to their HR defect, BRCA1/2-deficient cancers are sensitive to poly(ADP-ribose) polymerase inhibitors (PARPis), but they eventually acquire
Externí odkaz:
https://doaj.org/article/fd908dcc7cb748d2901dfd4eb935d917
Autor:
Max A.A. Ragusi, Tycho Bismeijer, Bas H.M. van der Velden, Claudette E. Loo, Sander Canisius, Jelle Wesseling, Lodewyk F.A. Wessels, Sjoerd G. Elias, Kenneth G.A. Gilhuijs
Publikováno v:
Breast, Vol 60, Iss , Pp 230-237 (2021)
Purpose: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Methods: Preoperative breast MRIs were anal
Externí odkaz:
https://doaj.org/article/a7a1e711194c46f9bfc41983bd3be40b
Autor:
Evert Bosdriesz, João M. Fernandes Neto, Anja Sieber, René Bernards, Nils Blüthgen, Lodewyk F.A. Wessels
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104760- (2022)
Summary: Targeted inhibition of aberrant signaling is an important treatment strategy in cancer, but responses are often short-lived. Multi-drug combinations have the potential to mitigate this, but to avoid toxicity such combinations must be selecti
Externí odkaz:
https://doaj.org/article/79751c290deb41b19b7a9a972294987f
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 201-211 (2020)
Intrinsic and acquired resistances are major hurdles preventing the effective use of MEK inhibitors for treatment of colorectal cancer (CRC). Some 35–45% of colorectal cancers are KRAS-mutant and their treatment remains challenging as these cancers
Externí odkaz:
https://doaj.org/article/d4a1feb306704b43bccc6c748991d9bd
Autor:
Fleur Jochems, Bram Thijssen, Giulia De Conti, Robin Jansen, Ziva Pogacar, Kelvin Groot, Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, René Bernards
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109441- (2021)
Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different i
Externí odkaz:
https://doaj.org/article/e5885b546531426bb7c25ec795372518
Autor:
Sjoerd Klarenbeek, Chris W. Doornebal, Sjors M. Kas, Nicola Bonzanni, Jinhyuk Bhin, Tanya M. Braumuller, Ingrid van der Heijden, Mark Opdam, Philip C. Schouten, Kelly Kersten, Roebi de Bruijn, Daniel Zingg, Julia Yemelyanenko, Lodewyk F.A. Wessels, Karin E. de Visser, Jos Jonkers
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of the major druggable oncoge
Externí odkaz:
https://doaj.org/article/54b9a172c50d4990871cfc2608c09c9c
Autor:
Nora Pencheva, Mark C. de Gooijer, Daniel J. Vis, Lodewyk F.A. Wessels, Tom Würdinger, Olaf van Tellingen, René Bernards
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 48-60 (2017)
Diffuse and uncontrollable brain invasion is a hallmark of glioblastoma (GBM), but its mechanism is understood poorly. We developed a 3D ex vivo organotypic model to study GBM invasion. We demonstrate that invading GBM cells upregulate a network of e
Externí odkaz:
https://doaj.org/article/92158c78b3084c8292bd15e73c2afcbc
Autor:
Ekaterina Nevedomskaya, Suzan Stelloo, Henk G. van der Poel, Jeroen de Jong, Lodewyk F.A. Wessels, Andries M. Bergman, Wilbert Zwart
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 124-126 (2016)
Prostate cancer (PCa) is the second most common cancer in men. The Androgen Receptor (AR) is the major driver of PCa and the main target of therapy in the advanced setting. AR is a nuclear receptor that binds the chromatin and regulates transcription
Externí odkaz:
https://doaj.org/article/b998e6103c6047ab991fb8c113c9c991