Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Lodewyk F A Wessels"'
Autor:
Bram Thijssen, Lodewyk F A Wessels
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230101 (2020)
An important feature of Bayesian statistics is the opportunity to do sequential inference: the posterior distribution obtained after seeing a dataset can be used as prior for a second inference. However, when Monte Carlo sampling methods are used for
Externí odkaz:
https://doaj.org/article/1aa612b8d5d94374a6b4d304812c6986
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 10, p e1006520 (2018)
Effective cancer treatment is crucially dependent on the identification of the biological processes that drive a tumor. However, multiple processes may be active simultaneously in a tumor. Clustering is inherently unsuitable to this task as it assign
Externí odkaz:
https://doaj.org/article/17346b17f3b14de99c5718e9369f7e74
Autor:
David M Vossen, Caroline V M Verhagen, Reidar Grénman, Roelof J C Kluin, Marcel Verheij, Michiel W M van den Brekel, Lodewyk F A Wessels, Conchita Vens
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206632 (2018)
BACKGROUND:Large cancer genome studies continue to reveal new players in treatment response and tumorigenesis. The discrimination of functional alterations from the abundance of passenger genetic alterations still poses challenges and determines DNA
Externí odkaz:
https://doaj.org/article/1ece493379cf446194cdc3f9516511b8
Autor:
Alberto Gil-Jimenez, Nick van Dijk, Joris L. Vos, Yoni Lubeck, Maurits L. van Montfoort, Dennis Peters, Erik Hooijberg, Annegien Broeks, Charlotte L. Zuur, Bas W. G. van Rhijn, Daniel J. Vis, Michiel S. van der Heijden, Lodewyk F. A. Wessels
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Immune checkpoint inhibitors (ICI) can achieve remarkable responses in urothelial cancer (UC), which may depend on tumor microenvironment (TME) characteristics. However, the relationship between the TME, usually characterized by immune cell
Externí odkaz:
https://doaj.org/article/a20ad317c6494fd7817047ddf7796a9d
Autor:
Johann de Jong, Waseem Akhtar, Jitendra Badhai, Alistair G Rust, Roland Rad, John Hilkens, Anton Berns, Maarten van Lohuizen, Lodewyk F A Wessels, Jeroen de Ridder
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004250 (2014)
The ability of retroviruses and transposons to insert their genetic material into host DNA makes them widely used tools in molecular biology, cancer research and gene therapy. However, these systems have biases that may strongly affect research outco
Externí odkaz:
https://doaj.org/article/1fdb8ab45ba54001862e8a69f4a6e2fa
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88551 (2014)
IntroductionDespite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases.
Externí odkaz:
https://doaj.org/article/d694dcb5c88a486ab2f015e14107d826
Autor:
Marieke A Vollebergh, Christiaan Klijn, Philip C Schouten, Jelle Wesseling, Danielle Israeli, Bauke Ylstra, Lodewyk F A Wessels, Jos Jonkers, Sabine C Linn
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103177 (2014)
Lymph-node metastasis (LNM) predict high recurrence rates in breast cancer patients. Systemic treatment aims to eliminate (micro)metastatic cells. However decisions regarding systemic treatment depend largely on clinical and molecular characteristics
Externí odkaz:
https://doaj.org/article/627f62365ed44631903e3bb2e86a2309
Autor:
Christiaan Klijn, Marco J Koudijs, Jaap Kool, Jelle ten Hoeve, Mandy Boer, Joost de Moes, Waseem Akhtar, Martine van Miltenburg, Annabel Vendel-Zwaagstra, Marcel J T Reinders, David J Adams, Maarten van Lohuizen, John Hilkens, Lodewyk F A Wessels, Jos Jonkers
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62113 (2013)
Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer dr
Externí odkaz:
https://doaj.org/article/235dc4eda4554bda99cc85df5fced711
Autor:
Christine Staiger, Sidney Cadot, Raul Kooter, Marcus Dittrich, Tobias Müller, Gunnar W Klau, Lodewyk F A Wessels
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34796 (2012)
Recently, several classifiers that combine primary tumor data, like gene expression data, and secondary data sources, such as protein-protein interaction networks, have been proposed for predicting outcome in breast cancer. In these approaches, new c
Externí odkaz:
https://doaj.org/article/a167674e722240d6823565dabc5d7908
Autor:
Martin H van Vliet, Hugo M Horlings, Marc J van de Vijver, Marcel J T Reinders, Lodewyk F A Wessels
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40358 (2012)
Breast cancer outcome can be predicted using models derived from gene expression data or clinical data. Only a few studies have created a single prediction model using both gene expression and clinical data. These studies often remain inconclusive re
Externí odkaz:
https://doaj.org/article/f703dd8691ba4d6f981af7d6f26ad2e3