Výsledky vyhledávání - "Lodewijk A, Sandkuijl"

Candidate gene approach in association studies: would the factor V Leiden mutation have been found by this approach?

Autor: Astrid van Hylckama Vlieg, Rogier M. Bertina, Lodewijk A. Sandkuijl, Hans L. Vos, Frits R. Rosendaal

Publikováno v: European Journal of Human Genetics. 12:478-482

A re-emerging strategy in the search for disease susceptibility genes is the evaluation of candidate genes, which are thought to play a role in disease pathogenesis. Candidate genes are screened for single nucleotide polymorphisms (SNPs) in a case-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a235c83335d3215c1fd29d115d44d1ca
https://doi.org/10.1038/sj.ejhg.5201183

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Linkage disequilibrium in young genetically isolated Dutch population

Autor: Lon R. Cardon, Tessa A. M. Rademaker, Yurii S. Aulchenko, Peter Heutink, Lodewijk A. Sandkuijl, Ben A. Oostra, Jan Pullen, Ian Mackay, Aida M. Bertoli-Avella, Norbert Vaessen, Cornelia M. van Duijn

Publikováno v: European Journal of Human Genetics, 12, 527-534. Nature Publishing Group

The design and feasibility of genetic studies of complex diseases are critically dependent on the extent and distribution of linkage disequilibrium (LD) across the genome and between different populations. We have examined genomewide and region-speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a9fd1bc63818b50324974850b7a7da
https://doi.org/10.1038/sj.ejhg.5201188

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Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations

Autor: Carol A. Mathews, Victor I. Reus, Julio Bejarano, Michael A. Escamilla, Eduardo Fournier, Luis Diego Herrera, Thomas L. Lowe, L. Alison McInnes, Julio Molina, Roel A. Ophoff, Henrietta Raventos, Lodewijk A. Sandkuijl, Susan K. Service, Mitzi Spesny, Pedro E. Le??n, Nelson B. Freimer

Publikováno v: Psychiatric Genetics. 14:13-23

The importance of genetics in understanding the etiology of mental illness has become increasingly clear in recent years, as more evidence has mounted that almost all neuropsychiatric disorders have a genetic component. It has also become clear, howe

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https://doi.org/10.1097/00041444-200403000-00003

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Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population

Autor: Cisca Wijmenga, Eric Strengman, Lodewijk A. Sandkuijl, Lude Franke, Peter L. Pearson, T.W. van Haeften, J. H. O. van Tilburg

Publikováno v: European Journal of Clinical Investigation. 33:1070-1074

A genome scan was performed in obese type 2 diabetes mellitus pedigrees to identify susceptibility loci involved in obesity-driven type 2 diabetes mellitus. We studied the 20% most obese diabetes pedigrees from a confined Dutch population from around

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https://doi.org/10.1111/j.1365-2362.2003.01276.x

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A major non-HLA locus in celiac disease maps to chromosome 191 1This study is dedicated to the memory of Lodewijk Sandkuijl (1953–2002), who died shortly after its completion. He was an inspiration to us and was a world expert on biostatistics

Autor: Roderick H. J. Houwen, Lodewijk A. Sandkuijl, Martine J. Van Belzen, Chris J. J. Mulder, Alfons F.J. Bardoel, Jos W. R. Meijer, Peter L. Pearson, Cisca Wijmenga

Publikováno v: Gastroenterology. 125:1032-1041

Background & aims: The pathogenesis of celiac disease is still unknown despite its well-known association with human leukocyte antigen (HLA)-DQ2 and DQ8. It is clear that non-HLA genes contribute to celiac disease development as well, but none of the

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https://doi.org/10.1016/s0016-5085(03)01205-8

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Familial Partial Epilepsy with Variable Foci in a Dutch Family: Clinical Characteristics and Confirmation of Linkage to Chromosome 22q

Autor: Dick Lindhout, Eelke H. Van Den Boogerd, Rune R. Frants, René de Coo, Lodewijk A. Sandkuijl, Petra M.C. Callenbach, Oebele F. Brouwer, Arn M. J. M. van den Maagdenberg, Jouke J. Hottenga

Publikováno v: Epilepsia. 44:1298-1305

Purpose: Three forms of idiopathic partial epilepsy with autosomal dominant inheritance have been described: (a) autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); (b) autosomal dominant lateral temporal epilepsy (ADLTE) or partial epilepsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bc7360fa5191516797283a2ae3ad1fb
https://doi.org/10.1046/j.1528-1157.2003.62302.x

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Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33

Autor: Lodewijk A. Sandkuijl, Victor I. Reus, Eduardo Fournier, L. Alison McInnes, Jennifer Lucas, Pedro León, Sandra Silva, Terry Song, Julio Molina, Kyung Sue Hong, Nelson B. Freimer

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :83-86

We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061-1064] of a locus on 5q predisposing to bipolar I disorder (BP-I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers i

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https://doi.org/10.1002/ajmg.b.20091

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Differential immunogenicity of paternal HLA Class I antigens in pregnant women

Autor: Ilias I.N. Doxiadis, Lodewijk A. Sandkuijl, Marlies K.A Dankers, Dave L. Roelen, Nelleke Korfage, Frans H.J. Claas, Marian D. Witvliet, Peter de Lange

Publikováno v: Human Immunology. 64:600-606

More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody

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https://doi.org/10.1016/s0198-8859(03)00058-2

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Cost-Effective Designs for Linkage Disequilibrium Mapping of Complex Traits

Autor: Susan K. Service, Lodewijk A. Sandkuijl, Nelson B. Freimer

Publikováno v: The American Journal of Human Genetics. 72:1213-1220

The current development of densely spaced collections of single nucleotide polymorphisms (SNPs) will lead to genomewide association studies for a wide range of diseases in many different populations. Determinations of the appropriate number of SNPs t

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https://doi.org/10.1086/375165

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