Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Lode Wyns"'
Autor:
Goedele Roos, Nicolas Foloppe, Koen Van Laer, Lode Wyns, Lennart Nilsson, Paul Geerlings, Joris Messens
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 8, p e1000461 (2009)
The dissociation mechanism of the thioredoxin (Trx) mixed disulfide complexes is unknown and has been debated for more than twenty years. Specifically, opposing arguments for the activation of the nucleophilic cysteine as a thiolate during the dissoc
Externí odkaz:
https://doaj.org/article/4f596919d83a42cda0c68aaf17e2fe37
Autor:
Adinda Wellens, Corinne Garofalo, Hien Nguyen, Nani Van Gerven, Rikard Slättegård, Jean-Pierre Hernalsteens, Lode Wyns, Stefan Oscarson, Henri De Greve, Scott Hultgren, Julie Bouckaert
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2040 (2008)
Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade
Externí odkaz:
https://doaj.org/article/2004e5b6fe774d33b79d497ec7b345e4
Autor:
Adinda Wellens, Corinne Garofalo, Hien Nguyen, Nani Van Gerven, Rikard Slättegård, Jean-Pierre Hernalsteens, Lode Wyns, Stefan Oscarson, Henri De Greve, Scott Hultgren, Julie Bouckaert
Publikováno v:
PLoS ONE, Vol 3, Iss 6 (2008)
Externí odkaz:
https://doaj.org/article/a51734a6a502469795197d9788520dda
Autor:
Lieven Buts, Sophie Vanwetswinkel, René Roy, Yann G.-J. Sterckx, Julie Bouckaert, Lode Wyns, Wim F. Vranken, Alexander N. Volkov, Nico A. J. van Nuland, Abel Garcia-Pino
Publikováno v:
Journal of Medicinal Chemistry. 57:1416-1427
Uropathogenic Escherichia coli cause urinary tract infections by adhering to mannosylated receptors on the human urothelium via the carbohydrate-binding domain of the FimH adhesin (FimHL). Numerous α-d-mannopyranosides, including α-d-heptyl mannose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e307ec3c349462be0d37490338dc30a7
https://doi.org/10.1021/jm401666c
https://doi.org/10.1021/jm401666c
Autor:
Mohamed Touaibia, Julie Bouckaert, Adinda Wellens, Nao Yamakawa, René Roy, Paul Geerlings, Goedele Roos, Lode Wyns
Publikováno v:
ACS Medicinal Chemistry Letters. 4:1085-1090
Antagonists of the FimH adhesin, a protein almost universally present at the extremity of type-1 fimbriae expressed by Escherichia coli, have been abundantly in the spotlight as alternative treatments of urinary tract infections. The antagonists func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69ac7714a651df883fbf1d99208a901
https://doi.org/10.1021/ml400269v
https://doi.org/10.1021/ml400269v
Autor:
Monica Stoppini, Florine Dupeux, Sofia Giorgetti, Vittorio Bellotti, Lode Wyns, Saskia Vanderhaegen, Els Pardon, Vasundara Srinivasan, Jan Steyaert, José A. Márquez, Katarzyna Domanska
Publikováno v:
Proceedings of the National Academy of Sciences. 108:1314-1319
Atomic-level structural investigation of the key conformational intermediates of amyloidogenesis remains a challenge. Here we demonstrate the utility of nanobodies to trap and characterize intermediates of beta 2-microglobulin (beta 2m) amyloidogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91a23b796801396db5b20a287a77a9d
https://doi.org/10.1073/pnas.1008560108
https://doi.org/10.1073/pnas.1008560108
Autor:
Elizabeth M. O'Day, Mireille Dumoulin, Christopher A. Waudby, John Christodoulou, Tim Guilliams, Christopher M. Dobson, Shang-Te Danny Hsu, Joke Wellens, Sarah Meehan, Nunilo Cremades, Lode Wyns, Erwin De Genst, Jan Steyaert, Koen H. G. Verschueren, Els Pardon
Publikováno v:
Journal of Molecular Biology. 402:326-343
The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's disease. The molecular mechanism of alpha-synucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdeb0fc5d56734725b1d0a783b26fe0
https://doi.org/10.1016/j.jmb.2010.07.001
https://doi.org/10.1016/j.jmb.2010.07.001
Autor:
Lode Wyns, Kristof Moonens, Julie Bouckaert, Henri De Greve, Inge Van Molle, Abel Garcia-Pino, Lieven Buts, Maia De Kerpel
Publikováno v:
Vrije Universiteit Brussel
Enterotoxigenic Escherichia coli expressing F4 fimbriae are the major cause of porcine colibacillosis and are responsible for significant death and morbidity in neonatal and postweaned piglets. Via the chaperone-usher pathway, F4 fimbriae are assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500e65fcc1a7049d34e3dbc51698bae8
https://doi.org/10.1016/j.jmb.2009.09.059
https://doi.org/10.1016/j.jmb.2009.09.059
Autor:
Michal Letek, Efrén Ordóñez, Sandra De Galan, Joris Messens, Luis M. Mateos, Goedele Roos, Lode Wyns, José A. Gil, Karolien Van Belle
Publikováno v:
Journal of Biological Chemistry. 284:15107-15116
We identified the first enzymes that use mycothiol and mycoredoxin in a thiol/disulfide redox cascade. The enzymes are two arsenate reductases from Corynebacterium glutamicum (Cg_ArsC1 and Cg_ArsC2), which play a key role in the defense against arsen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c2ac83ac57bb366d6a5a24e7803d32
https://doi.org/10.1074/jbc.m900877200
https://doi.org/10.1074/jbc.m900877200
Autor:
Ulrich Wernery, Viet Nguyen, Hilde Revets, Sergei Tillib, P. De Baetselier, Toya Nath Baral, V. Cortez Retamozzo, Lode Wyns, Gh. Hassanzadeh-Ghassabeh, Stefan Magez, Dirk Saerens, Benoit Stijlemans, E. De Genst, J. Kinne, Heinrich Leonhardt, Ulrich Rothbauer, Serge Muyldermans
Publikováno v:
Vrije Universiteit Brussel
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
It is well established that all camelids have unique antibodies circulating in their blood. Unlike antibodies from other species, these special antibodies are devoid of light chains and are composed of a heavy-chain homodimer. These so-called heavy-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee20d287b5d732551c6ba3bfa91c4e03
https://doi.org/10.1016/j.vetimm.2008.10.299
https://doi.org/10.1016/j.vetimm.2008.10.299