Development of optogenetic approaches to selectively modulate G protein signalling

Autor: Lockyer, JL

G protein coupled receptors, or GPCRs, transduce signals from neuromodulators and permit dynamic regulation of neuronal circuits. Gradually, we have come to understand the processes underlying neural function and the molecular underpinnings of higher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706009d80c0d145f3254fd757519d316

Selective optogenetic inhibition of Gα q or Gα i signaling by minimal RGS domains disrupts circuit functionality and circuit formation.

Autor: Lockyer JL; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia., Reading A; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia., Vicenzi S; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia., Zbela A; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia., Viswanathan S; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia., Delandre C; Menzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia., Newland JW; Menzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia., McMullen JPD; Menzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia., Marshall OJ; Menzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia., Gasperini R; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia., Foa L; School of Psychological Sciences, University of Tasmania, Sandy Bay, TAS 7005, Australia., Lin JY; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Sep 03; Vol. 121 (36), pp. e2411846121. Date of Electronic Publication: 2024 Aug 27.