CD4+ T-cell subsets: Regulation of differentiation and function: Discussion

Autor: Swain, SL, Gajewski, TF, Fitch, FW, Locksley, RM, Daynes, RA, Araneo, BA, Powrie, F, Fowell, D, McKnight, AJ, Mason, D, Romagnani, S, Bretscher, PA, Mosmann, T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1583ed79ea8118d593d1dc1c5c75a1f3
https://ora.ox.ac.uk/objects/uuid:bf3e109e-4989-43b8-ae98-439c88cc3a22

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

Autor: Allen, Christopher, Cheng, Laurence, Locksley, Richard, Cheng, LE, Sullivan, BM, Retana, LE, Allen, CDCCDC, Liang, HE, Locksley, RM

Publikováno v: Allen, Christopher; Cheng, Laurence; Locksley, Richard; Cheng, LE; Sullivan, BM; Retana, LE; et al.(2015). IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3s21v989

© 2015 Mantovani and Allavena.Vertebrate immunity has evolved a modular architecture in response to perturbations. Allergic inflammation represents such a module, with signature features of antigen-specific IgE and tissue eosinophilia, although the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e8484ebd109bcad21996a75636093d7e
http://www.escholarship.org/uc/item/3s21v989

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy

Autor: Van Gool, F, Molofsky, AB, Morar, MM, Rosenzwajg, M, Liang, HE, Klatzmann, D, Locksley, RM, Bluestone, JA

Publikováno v: Blood, vol 124, iss 24
Van Gool, F; Molofsky, AB; Morar, MM; Rosenzwajg, M; Liang, HE; Klatzmann, D; et al.(2014). Interleukin-5-Producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood, 124(24), 3572-3576. doi: 10.1182/blood-2014-07-587493. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9t34x2d3

© 2014 by The American Society of Hematology. Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases. However, patients receiving IL-2 treatment also ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::229bc6cbf36e628c84d0c7a478b58c3a
https://escholarship.org/uc/item/9t34x2d3

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

Autor: Krummel, Matthew, Rosen, Steven, Locksley, Richard, Patnode, ML, Bando, JK, Krummel, MF, Locksley, RM, Rosen, SD

Publikováno v: Krummel, Matthew; Rosen, Steven; Locksley, Richard; Patnode, ML; Bando, JK; Krummel, MF; et al.(2014). Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8c49q9gs

Eosinophil accumulation is a defining feature of the immune response to parasitic worm infection. Tissue-resident cells, such as epithelial cells, are thought to initiate eosinophil recruitment. However, direct recognition of worms by eosinophils has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::789f0608070ce01352fa541029ef2d9c
http://www.escholarship.org/uc/item/8c49q9gs

Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism

Autor: Bix, M, Wang, ZE, Thiel, B, Schork, NJ, Locksley, RM

Publikováno v: The Journal of experimental medicine, vol 188, iss 12

The dysregulated expression of interleukin 4 (IL-4) can have deleterious effects on the outcome of infectious and allergic diseases. Despite this, the mechanisms by which naive T cells commit to IL-4 expression during differentiation into mature effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::63c9e6a7dd0984e313960ff359556e2e
https://escholarship.org/uc/item/0b44g4sn