A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

Autor: Zhiping Hu, Takeshi Kurihara, Yiyue Sun, Zeliha Cetin, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Zhenghao Liu, Bo Yang, Alina Ostrowska, Joseph D. Locker, Alejandro Soto-Gutierrez, Evan R. Delgado

Publikováno v: Frontiers in Gastroenterology, Vol 3 (2024)

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, and commonly associated with hepatic fibrosis or cirrhosis. This study aims to establish a rat model mimicking the progression from liver fibrosis to cirrhosis and subsequent

Externí odkaz: https://doaj.org/article/0ba87285b6114e80a427824b190da594

Uveitic glaucoma-like features in Yap conditional knockout mice

Autor: Juliette Bitard, Elodie-Kim Grellier, Sophie Lourdel, Helena Prior Filipe, Annaïg Hamon, François Fenaille, Florence Anne Castelli, Emeline Chu-Van, Jérôme E. Roger, Morgane Locker, Muriel Perron

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Abstract Glaucoma is a multifactorial neurodegenerative disease characterized by the progressive and irreversible degeneration of the optic nerve and retinal ganglion cells. Despite medical advances aiming at slowing degeneration, around 40% of treat

Externí odkaz: https://doaj.org/article/5094564ec34949d59e846b3ed1d20852

Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

Autor: Vera Magg, Alessandro Manetto, Katja Kopp, Chia Ching Wu, Mohsen Naghizadeh, Doris Lindner, Lucy Eke, Julia Welsch, Stefan M. Kallenberger, Johanna Schott, Volker Haucke, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114069- (2024)

Summary: The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation

Externí odkaz: https://doaj.org/article/57ac933c39544e17ab8442346bf13c6f

Outcomes Following Vascular and Endovascular Procedures Performed During the First COVID-19 Pandemic Wave

Autor: Birmpili, Panagiota, Benson, Ruth A., Gwilym, Brenig, Nandhra, Sandip, Al-Saadi, Nina, Ambler, Graeme K., Blair, Robert, Bosanquet, David, Dattani, Nikesh, Hitchman, Louise, Hurndall, Katherine, Machin, Matthew, Onida, Sarah, Saratzis, Athanasios, Shalhoub, Joseph, Lauren, Shelmerdine, Singh, Aminder Anthony, Bosanquet, David C., Forsythe, Rachael O., Dovell, George, Preece, Ryan, Imray, Chris, Kandola, Sonia, Johnson, Adam, Choong, Andrew, Ng, Jun Jie, Aitken, Sarah, Moss, Jana-Lee, Beropoulis, Efthymios, Stavroulakis, Konstantinos, Santiago, Fabrico, Abdelhaliem, Amr, Abuduruk, Aseel, Aherne, Thomas M., Ahmed, Hazem, Aitken, Sarah J., Akhtar, Tasleem, Akkaya, Bekir B., Al Shakarchi, Julien, Algasi, Abdeljawad J., AlHamzah, Musaad, Alhumiad, Ahmed A., Allard, Bernard, Almeshal, Meshal, Alomran, Faris, AlRakaf, Reem N., Altabal, Mohamed, Altaf, Nishath, Altoijry, Abdulmajeed H., Altuwaijri, Talal, Alwehaibi, Nasser, Anderson Baker, Sara J., Angiletta, Domenico, Antoniou, Afroditi, Antoniou, George A., Areias, Libnah L., Ashcroft, James, Atkinson, Noel, Attia, Doaa, Attwell, Lukas, Azab, Mohammed A., Aziz, Omar, Azzam, Ahmed Y., Bakoyiannis, Christos, Barakat, Hashem, Bashar, Khalid, Battersby, Ruth, Benaragama, K.S., BenGhatnsh, Ahmed T.S., Bessias, Nikolaos, Bhakthavalsalan, Resya, Binkhamis, Shagran, Bootun, Roshan, Boyle, Emily, Buga, Ion, Catterson, Martin, Chambers, Jennifer L., Chandarana, Karishma, Charalabopoulos, Alexandros, Charlton, Gabriella, Cheng, Stephen W.K., Chinai, Natasha, Choudhry, Asad J., Clothier, Annie, Cohnert, Tina U., Coleman, Chloe, Costanza, Michael, Coughlin, Patrick A., Coulston, James, Cragg, James, Darvall, Katy, Davies, Emma M., Davies, Huw, Dawkins, Claire, Dawson, Joseph A., Dean, Anastasia, Dhal, Bedanta S., Duncan, Andrew, Edwards, Mark, Egan, Bridget, El Amrani, Mehdi, Elhadi, Ahmed, Elhadi, Muhammed, Eljareh, Mohamed S., Elkady, Ramy, Elkawafi, Mohamed, Elkhafeefi, Fatimah S., Elkwahad, Maysoon, Ellojli, Ibrahim A., ElSanhoury, Kareem, Elsantawy, Hazem, Elsayed, Khaled, Ennab, Raed M., Fisher, Owain, Fitridge, Robert, Flumignan, Ronald L.G., Fowler, Amy L., Galloway, Richard F., Gan, John, Garnham, Andrew, Georgopoulos, Sotirios, Ghatwary Tantawy, Tamer M.H., Goel, Ravi R., Goh, Mingzheng A., Grainger, Tabitha, Gunawansa, Nalaka, Hammond, Eric, Hanna, Joseph, Hardy, Simon C., Hardy, Thomas J., Harrison, Gareth J., Hassanin, Ahmed, Hattam, Andrew T., Hein, Martin, Hmaid, Hytham K.S., Hon, Kay, Iqbal, Kaisor, Iscan, Hakkı Z., Isik, Arda, Joyce, Doireann P., Juszczak, Maciej, Kakavia, Kiriaki, Kakkos, Stavros, Karkos, Christos D., Katsogridakis, Emmanuel, Khalil, Rana, Khallaf, Andrew I., Khan, Aazeb, Khashram, Manar, Khoo, Samantha, Kilby, Joseph, Kuang, Beatrice, Kyrou, Ioanna, Lapolla, Pierfrancesco, Leong, Kai W., Lim, Eunice, Liu, Ju-wei N., Locker, Dafydd, Luo, Xun, Lyons, Oliver T.A., Makar, Ragai R., Maras, Dimitris, Martin, Emmeline A., Mavioglu, Hayrettin L., Mazingi, Dennis, McCaslin, James, McClure, David N., McKevitt, Kevin, Meecham, Lewis, Mehta, Shreya, Minelli, Fabrizio, Mingoli, Andrea, Mitka, Afroditi M., Mohamed, Farag S., Moore, Hayley M., Morley, Rachael L., Moulakakis, Konstantinos G., Mpaili, Eustratia, Msherghi, Ahmed, Muhammad, Kamel, Muller, Juanita, Musicki, Korana, Nakano, Luis C.U., Nesbitt, Craig, Nicholls, Jonathan, Nickinson, Andrew, Nouh, Thamer, Nunag, Jose M.S., Nyamekye, Isaac K., Papanikolas, Michael J., Papas, Theofanis T., Papazoglou, Konstantinos O., Paravastu, Sharath, Parr, Noala, Pasenidou, Ketino, Pineda, Fernando Picazo, Pond, Franklin, Popplewell, Matthew A., Powezka, Katarzyna, Prce, Daniela, Premnath, Sivaram, Pulli, Raffaele, Rabee, Hussein M.M., Rahman, Habibur P., Ravintharan, Nandhini, Valdivia, Andrés Reyes, Richards, Toby, Roditis, Konstantinos, Rolls, Alexander E.S., Roy, Iain N., Saeed, Hani, Saha, Prakash, Saltiel, Alberto, Sapienza, Paolo, Scott, Emma, Selvaraj, Christopher N., Sharif, Atif, Sica, Simona, Silickas, Justinas, Singh, Gurkirat, Sivaharan, Ashwin, Sivakumaran, Yogeesan, Somaiya, Pranav, Stansby, Gerry, Stavert, Bethany M., Sudarsanam, Abhilash, Suthers, Elizabeth, Suttenwood, Helen, Taha, Ahmed, Taha, Mohamed A.H., Tam, Siu C., Tang, Alethea M., Tang, Robert, Taran, Dana, Tarusan, Lawrence, Thet, Myat S., Thomas, Jacqueline, Tierney, Sean, Tigkiropoulos, Konstantinos, Tinelli, Giovanni, Tolba, Mahmoud M.H., Travers, Hannah C., Tsagkos, Ioannis, Tshomba, Yamume, Tsiantoula, Paraskevi, Twine, Christopher P., Ulker, Berkay, Ulusoy, Serap, Unal, Ertekin U., Varley, Vincent C., Vasudevan, Thodur M., Vo, Uyen G., Wagner, Timothy, Walsh, Stewart R., Wang, Judy, Wong, Jackie, Warren, Sarah A., Yih, Chun L.P., Zacà, Sergio, Zafar, Adeel S., Zaki, Shady, Zywicka, Ewa M., Shelmerdine, Lauren, Singh, Aminder A.

Publikováno v: In EJVES Vascular Forum 2024 62:64-71

Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure

Autor: Melis, Marta, Marino, Rebecca, Tian, Jianmin, Johnson, Carla, Sethi, Rahil, Oertel, Michael, Fox, Ira J., Locker, Joseph

Publikováno v: In Cellular and Molecular Gastroenterology and Hepatology 2024 17(3):453-479