Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lochlan J Fennell"'
Autor:
Alexandra M. Kane, Lochlan J. Fennell, Cheng Liu, Jennifer Borowsky, Diane M. McKeone, Catherine E. Bond, Stephen Kazakoff, Ann-Marie Patch, Lambros T. Koufariotis, John Pearson, Nicola Waddell, Barbara A. Leggett, Vicki L.J. Whitehall
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 120-128 (2020)
The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAFV600E and the CpG Island Methylator Phenotype (CIMP). BRAF mutant CRC are commonly associated with microsatellite insta
Externí odkaz:
https://doaj.org/article/54cf7836ff7a4539bd24d079728bf56e
Autor:
Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018)
Abstract Background Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the
Externí odkaz:
https://doaj.org/article/bb82f40e1840403ba62324331328b137
Autor:
Lochlan J Fennell, Gunter Hartel, Diane M McKeone, Catherine E Bond, Alexandra Kane, Barbara A Leggett, Ann-Marie Patch, Vicki LJ Whitehall
BackgroundResearching the murine epigenome in disease models has been hampered by the lack of an appropriate and cost-effective DNA methylation array. Until recently, investigators have been limited to the relatively expensive and analysis intensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785888697d50cbdccb97e80abd13d0e7
https://doi.org/10.1101/2022.03.07.483250
https://doi.org/10.1101/2022.03.07.483250
Autor:
Chang Su, Lochlan J Fennell, Catherine E Bond, Alexandra M Kane, Genevieve Kerr, Thierry Jardé, Diana Micati, Rebekah M Engel, Wing Hei Chan, Sara Hlavca, Stuart Archer, Paul J McMurrick, Heinz Hammerlindl, Fayth Lim, Basit Salik, Diane M McKeone, Gunter Hartel, Jennifer Borowsky, Rahul Ladwa, Barbara A Leggett, Helmut Schaider, Helen E Abud, Glen M Boyle, Matthew E Burge, Vicki LJ Whitehall
PurposeRegorafenib is a multi-kinase inhibitor approved for refractory metastatic colorectal cancer. Previous studies have suggested that combining kinase inhibitors with aspirin may improve patient outcomes. We aimed to determine the effects of aspi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08e038486c64e20f79f3d5071b95732
https://doi.org/10.1101/2022.02.11.480021
https://doi.org/10.1101/2022.02.11.480021
Autor:
Lochlan J. Fennell, Gunter Hartel, Diane M. McKeone, Catherine E. Bond, Alexandra Kane, Barbara A. Leggett, Ann-Marie Patch, Vicki L.J. Whitehall
Publikováno v:
Cell Reports Methods. 2:100323
Researching the murine epigenome in disease models has been hampered by the lack of appropriate and cost-effective DNA methylation arrays. Here we perform a comprehensive, comparative analysis between the Mouse Methylation BeadChip (MMB) and reduced-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6845d804a44673b38c294fb13988305d
https://doi.org/10.1016/j.crmeth.2022.100323
https://doi.org/10.1016/j.crmeth.2022.100323
Autor:
Megan Rohdmann, Lochlan J. Fennell, Vicki L. J. Whitehall, Cheng Liu, Barbara A. Leggett, Saara Jamieson, Mark Bettington, Futoshi Kawamata, Tori Furner, Jolieke Van De Pols, Catherine Bond, Tracie Corish, Diane McKeone
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018)
BMC Cancer
BMC Cancer
Background Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6aac74f7c35566ba8dba46f409b2a56
https://doi.org/10.1186/s12885-017-3946-5
https://doi.org/10.1186/s12885-017-3946-5