Oatp (Organic Anion Transporting Polypeptide)-Mediated Transport: A Mechanism for Atorvastatin Neuroprotection in Stroke.

Autor: Williams EI; Department of Pharmacology, College of Medicine, University of Arizona, Tucson., Betterton RD; Department of Pharmacology, College of Medicine, University of Arizona, Tucson., Stanton JA; Department of Pharmacology, College of Medicine, University of Arizona, Tucson., Moreno-Rodriguez VM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson., Lochhead JJ; Department of Pharmacology, College of Medicine, University of Arizona, Tucson., Davis TP; Department of Pharmacology, College of Medicine, University of Arizona, Tucson., Ronaldson PT; Department of Pharmacology, College of Medicine, University of Arizona, Tucson.

Publikováno v: Stroke [Stroke] 2023 Nov; Vol. 54 (11), pp. 2875-2885. Date of Electronic Publication: 2023 Sep 26.

Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor- β /Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins).

Autor: Betterton RD; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Abdullahi W; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Williams EI; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Lochhead JJ; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Brzica H; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Stanton J; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Reddell E; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Ogbonnaya C; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Davis TP; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona., Ronaldson PT; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona pronald@email.arizona.edu.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Jul; Vol. 50 (7), pp. 942-956. Date of Electronic Publication: 2022 May 03.

β IV -spectrin as a stalk cell-intrinsic regulator of VEGF signaling.

Autor: Kwak EA; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Pan CC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27710, USA., Ramonett A; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Kumar S; Division of Biology, Indian Institute of Science Education and Research, Tirupati, 517507, India., Cruz-Flores P; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ, 85724, USA., Ahmed T; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ, 85724, USA., Ortiz HR; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Lochhead JJ; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Ellis NA; Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, 85724, USA., Mouneimne G; Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, 85724, USA., Georgieva TG; BIO5 Institute, University of Arizona, Tucson, AZ, 85724, USA., Lee YS; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Vanderah TW; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Largent-Milnes T; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA., Mohler PJ; Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, 43210, USA., Hund TJ; Department of Biomedical Engineering, Ohio State University, Columbus, OH, 43210, USA., Langlais PR; Department of Internal Medicine, University of Arizona, Tucson, AZ, 85724, USA., Mythreye K; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Lee NY; Department of Pharmacology, University of Arizona, Tucson, AZ, 85724, USA. namlee@email.arizona.edu.; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ, 85724, USA. namlee@email.arizona.edu.; Cancer Center, University of Arizona, Tucson, AZ, 85724, USA. namlee@email.arizona.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Mar 14; Vol. 13 (1), pp. 1326. Date of Electronic Publication: 2022 Mar 14.

Aging Increases Hypoxia-Induced Endothelial Permeability and Blood-Brain Barrier Dysfunction by Upregulating Arginase-II.

Autor: Xin Cheng¹, Potenza, Duilio M.¹, Brenna, Andrea¹, Ajalbert, Guillaume¹, Zhihong Yang¹ zhihong.yang@unifr.ch, Xiu-Fen Ming¹

Publikováno v: Aging & Disease. Nov2024, Vol. 15 Issue 6, p2710-2726. 17p.

Pharmacokinetic Study of Fingolimod Nasal Films Administered via Nose-to-Brain Route in C57BL/6 J Mice as Potential Treatment for Multiple Sclerosis.

Autor: Papakyriakopoulou P; Department of Pharmacy, School of Health Sciences Sector of Pharmaceutical Technology, National and Kapodistrian University of Athens, Athens, 15784, Greece., Balafas E; Laboratory Animal Facility, Centre of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, 11527, Greece., Kostomitsopoulos N; Laboratory Animal Facility, Centre of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, 11527, Greece., Rekkas DM; Department of Pharmacy, School of Health Sciences Sector of Pharmaceutical Technology, National and Kapodistrian University of Athens, Athens, 15784, Greece., Dev KK; Department of Physiology, Drug Development Research Group, School of Medicine, Trinity College Dublin, Dublin, D18 DH50, Ireland. devk@tcd.ie., Valsami G; Department of Pharmacy, School of Health Sciences Sector of Pharmaceutical Technology, National and Kapodistrian University of Athens, Athens, 15784, Greece. valsami@pharm.uoa.gr.

Publikováno v: Pharmaceutical research [Pharm Res] 2024 Oct; Vol. 41 (10), pp. 1951-1963. Date of Electronic Publication: 2024 Oct 29.