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Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter.

Autor: Zampaloni C; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Mattei P; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Bleicher K; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; SixPeaks Bio, Basel, Switzerland., Winther L; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Thäte C; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; Preclinical Sciences and Translational Safety, Janssen Pharmaceutica, Beerse, Belgium., Bucher C; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Adam JM; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; AutoChem R&D, Mettler-Toledo International, Greifensee, Switzerland., Alanine A; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; Independent consultant, Cambridge, Great Britain., Amrein KE; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Baidin V; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Bieniossek C; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Bissantz C; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Boess F; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Cantrill C; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Clairfeuille T; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Dey F; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Di Giorgio P; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., du Castel P; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Dylus D; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Dzygiel P; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Felici A; Discovery Microbiology, Aptuit (Verona) Srl, an Evotec Company, Verona, Italy., García-Alcalde F; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Haldimann A; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Leipner M; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Leyn S; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Louvel S; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Misson P; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Osterman A; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Pahil K; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Rigo S; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Schäublin A; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; SixPeaks Bio, Basel, Switzerland., Scharf S; Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Schmitz P; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Stoll T; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Trauner A; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Zoffmann S; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.; Therapeutics Discovery, Janssen Pharmaceutica, Beerse, Belgium., Kahne D; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Young JAT; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Lobritz MA; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland. michael.lobritz@roche.com., Bradley KA; Roche Pharma Research and Early Development, Immunology, Infectious Disease and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland. kenneth.bradley@roche.com.

Publikováno v: Nature [Nature] 2024 Jul; Vol. 631 (8022), pp. E17.

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Akademický článek

A novel antibiotic class targeting the lipopolysaccharide transporter.

Publikováno v: Nature [Nature] 2024 Jan; Vol. 625 (7995), pp. 566-571. Date of Electronic Publication: 2024 Jan 03.

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Editorial & Opinion

Low neutralizing antibody titers after asymptomatic or non-severe SARS-CoV-2 infection over a 6-month assessment period.

Autor: Lazor-Blanchet C; Occupational health unit, Service of Hospital Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Zygoura P; Frontier Science Foundation-Hellas, Athens, Greece., Dafni U; Frontier Science Foundation-Hellas, Athens, Greece; National and Kapodistrian University of Athens, Athens, Greece., Lamoth F; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Institute of Microbiology, Lausanne University Hospital and University, Lausanne, Switzerland., Tsourti Z; Frontier Science Foundation-Hellas, Athens, Greece., Lobritz MA; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Regina J; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Grandbastien B; Service of Hospital Preventive Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland., Fenwick C; Immunology Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Pantaleo G; Immunology Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Calandra T; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Meylan S; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: Sylvain.meylan@chuv.ch.

Publikováno v: The Journal of infection [J Infect] 2022 May; Vol. 84 (5), pp. 722-746. Date of Electronic Publication: 2022 Feb 05.

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Akademický článek

Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality.

Autor: Lobritz MA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Andrews IW; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Braff D; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA., Porter CBM; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Gutierrez A; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Furuta Y; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Cortes LBG; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Ferrante T; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA., Bening SC; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Wong F; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Gruber C; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bakerlee CW; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Lambert G; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Walker GC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dwyer DJ; Department of Cell Biology and Molecular Genetics, Institute for Physical Science and Technology, Department of Biomedical Engineering, and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA. Electronic address: djdwyer@umd.edu., Collins JJ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address: jimjc@mit.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2022 Feb 17; Vol. 29 (2), pp. 276-286.e4. Date of Electronic Publication: 2022 Jan 05.

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Akademický článek

SARS-CoV-2 seroprevalence in healthcare workers of a Swiss tertiary care centre at the end of the first wave: a cross-sectional study.

Autor: Meylan S; Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland sylvain.meylan@chuv.ch., Dafni U; Laboratory of Biostatistics, School of Health Sciences, Frontier Science Foundation-Hellas and University of Athens, Athens, Greece., Lamoth F; Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Tsourti Z; Laboratory of Biostatistics, School of Health Sciences, Frontier Science Foundation-Hellas and University of Athens, Athens, Greece., Lobritz MA; Roche Biomedical, Basel, Switzerland., Regina J; Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Bressin P; Occupational Health Service, Lausanne University Hospital, Lausanne, Switzerland., Senn L; Service of Hospital Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Grandbastien B; Service of Hospital Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Andre C; Immunology Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Fenwick C; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., D'Acremont V; Department of Ambulatory Care and Community Medicine, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland., Croxatto A; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Guilleret I; Clinical Trial Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Greub G; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Manuel O; Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Calandra T; Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Pantaleo G; Immunology Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Lazor-Blanchet C; Occupational Health Service, Lausanne University Hospital, Lausanne, Switzerland.

Publikováno v: BMJ open [BMJ Open] 2021 Jul 05; Vol. 11 (7), pp. e049232. Date of Electronic Publication: 2021 Jul 05.

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Akademický článek

Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1.

Autor: Klein K; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada kklein5@uwo.ca earts@uwo.ca., Nankya I; Joint Clinical Research Centre, Kampala, Uganda., Nickel G; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Ratcliff AN; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Meadows AAJ; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada., Hathaway N; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Bailey JA; Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA., Stieh DJ; Department of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom., Cheeseman HM; Department of Medicine, Imperial College London, London, United Kingdom., Carias AM; Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Lobritz MA; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Mann JFS; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada., Gao Y; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Hope TJ; Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Shattock RJ; Department of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom.; Department of Medicine, Imperial College London, London, United Kingdom., Arts EJ; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada kklein5@uwo.ca earts@uwo.ca.; Joint Clinical Research Centre, Kampala, Uganda.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Publikováno v: Journal of virology [J Virol] 2021 Jan 13; Vol. 95 (3). Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).

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Akademický článek

Bacterial Metabolism and Antibiotic Efficacy.

Autor: Stokes JM; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease & Microbiome Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Machine Learning for Pharmaceutical Discovery and Synthesis Consortium, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lopatkin AJ; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease & Microbiome Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA., Lobritz MA; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland., Collins JJ; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease & Microbiome Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address: jimjc@mit.edu.

Publikováno v: Cell metabolism [Cell Metab] 2019 Aug 06; Vol. 30 (2), pp. 251-259. Date of Electronic Publication: 2019 Jul 03.

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Akademický článek

Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics.

Autor: Gutierrez A; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Jain S; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02115, USA., Bhargava P; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Hamblin M; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Lobritz MA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Collins JJ; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address: jimjc@mit.edu.

Publikováno v: Molecular cell [Mol Cell] 2017 Dec 21; Vol. 68 (6), pp. 1147-1154.e3. Date of Electronic Publication: 2017 Dec 07.

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