Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

Autor: Grabovsky, V, Feigelson, S, Chen, C, Bleijs, D A, Peled, A, Cinamon, G, Baleux, F, Arenzana-Seisdedos, F, Lapidot, T, van Kooyk Y, Yvette, Lobb, R R, Alon, R

Publikováno v: Journal of Experimental Medicine, 192(4), 495-506. Rockefeller University Press
Grabovsky, V, Feigelson, S, Chen, C, Bleijs, D A, Peled, A, Cinamon, G, Baleux, F, Arenzana-Seisdedos, F, Lapidot, T, van Kooyk Y, Lobb, R R & Alon, R 2000, ' Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions ', Journal of Experimental Medicine, vol. 192, no. 4, pp. 495-506 .

Leukocyte recruitment to target tissue is initiated by weak rolling attachments to vessel wall ligands followed by firm integrin-dependent arrest triggered by endothelial chemokines. We show here that immobilized chemokines can augment not only arres

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https://research.vumc.nl/en/publications/d3ef8f04-ab73-416e-adec-ec45af72e020

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