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pro vyhledávání: '"Lobb, Ian T."'
Akademický článek
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Autor:
Burr, Stephen P., Costa, Ana S.H., Grice, Guinevere L., Timms, Richard T., Lobb, Ian T., Freisinger, Peter, Dodd, Roger B., Dougan, Gordon, Lehner, Paul J., Frezza, Christian, Nathan, James A.
Publikováno v:
In Cell Metabolism 8 November 2016 24(5):740-752
Akademický článek
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Akademický článek
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Autor:
Chen, Jingyu, Lobb, Ian T, Morin, Pierre, Novo, Sonia M, Simpson, James, Kennerknecht, Kathrin, von Kriegsheim, Alex, Batchelor, Emily E, Oakley, Fiona, Stark, Lesley A
Publikováno v:
Chen, J, Lobb, I T, Morin, P, Novo, S M, Simpson, J, Kennerknecht, K, von Kriegsheim, A, Batchelor, E E, Oakley, F & Stark, L A 2018, ' Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway ', Nucleic Acids Research, vol. 46, no. 12, pp. 6188–6205 . https://doi.org/10.1093/nar/gky455
p53 as an effector of nucleolar stress is well defined, but p53 independent mechanisms are largely unknown. Like p53, the NF-κB transcription factor plays a critical role in maintaining cellular homeostasis under stress. Many stresses that stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::6b4033de17f0697b0fc49d11ccd70abd
https://hdl.handle.net/20.500.11820/e16aa7be-73f0-4a29-b950-dd521ab462fa
https://hdl.handle.net/20.500.11820/e16aa7be-73f0-4a29-b950-dd521ab462fa
Autor:
Stefanovic-Barrett, Sandra, Dickson, Anna S, Burr, Stephen P, Williamson, James C, Lobb, Ian T, Van Den Boomen, Dick Jh, Lehner, Paul J, Nathan, James A
Misfolded or damaged proteins are typically targeted for destruction by proteasome-mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human cells, we find that the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72735d88d08f1ccdb03a5bfbc46d92d3
https://www.repository.cam.ac.uk/handle/1810/275453
https://www.repository.cam.ac.uk/handle/1810/275453
Autor:
Stefanovic‐Barrett, Sandra, Dickson, Anna S, Burr, Stephen P, Williamson, James C, Lobb, Ian T, van den Boomen, Dick JH, Lehner, Paul J, Nathan, James A
Publikováno v:
EMBO Reports
Misfolded or damaged proteins are typically targeted for destruction by proteasome‐mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human cells, we find that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22277d8d62e2475689aeb9f286c6ed47
http://europepmc.org/articles/PMC5934766
http://europepmc.org/articles/PMC5934766
The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains
Autor:
Grice, Guinevere L, Lobb, Ian T, Weekes, Michael P, Gygi, Steven P, Antrobus, Robin, Nathan, James A
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 545-553 (2015)
SummaryProteasome-mediated degradation occurs with proteins principally modified with lysine-48 polyubiquitin chains. Whether the proteasome also can bind atypical ubiquitin chains, including those linked by lysine-11, has not been well established.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::148ee9cddbc838c809aaceebcc627989
Autor:
Chen, Jingyu, Lobb, Ian T, Morin, Pierre, Novo, Sonia M, Simpson, James, Kennerknecht, Kathrin, von Kriegsheim, Alex, Batchelor, Emily E, Oakley, Fiona, Stark, Lesley A
Publikováno v:
Nucleic Acids Research; 7/6/2018, Vol. 46 Issue 12, p6188-6205, 18p
Autor:
Ortmann, Brian M, Burrows, Natalie, Lobb, Ian T, Arnaiz, Esther, Wit, Niek, Bailey, Peter SJ, Jordon, Louise H, Lombardi, Olivia, Peñalver, Ana, McCaffrey, James, Seear, Rachel, Mole, David R, Ratcliffe, Peter J, Maxwell, Patrick H, Nathan, James A
Hypoxia-inducible transcription factors (HIFs) are fundamental to cellular adaptation to low oxygen levels, but it is unclear how they interact with chromatin and activate their target genes. Here, we use genome-wide mutagenesis to identify genes inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f6f80b09b07c456711e742a3e450db