Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Loana, Musso"'
Autor:
Stefania Mazzini, Gigliola Borgonovo, Salvatore Princiotto, Roberto Artali, Loana Musso, Anna Aviñó, Ramon Eritja, Raimundo Gargallo, Sabrina Dallavalle
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0306239 (2024)
Quadruplex-Duplex (Q-D) junctions are unique structural motifs garnering increasing interest as drug targets, due to their frequent occurrence in genomic sequences. The viral HIV LTR-III sequence was chosen as a Q-D junction model to study the affini
Externí odkaz:
https://doaj.org/article/2331e4309b364e6eae6e62f9e04df694
Autor:
Salvatore Princiotto, Loana Musso, Fabrizio Manetti, Valentina Marcellini, Giovanni Maga, Emmanuele Crespan, Cecilia Perini, Nadia Zaffaroni, Giovanni Luca Beretta, Sabrina Dallavalle
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2382-2394 (2022)
Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years as chemotherapeutic agents. Starting from the biological evaluation of an in-house collect
Externí odkaz:
https://doaj.org/article/95aeb38bd14c4805af558781c3254a39
Autor:
Sabrina Dallavalle, Loana Musso, Roberto Artali, Anna Aviñó, Leonardo Scaglioni, Ramon Eritja, Raimundo Gargallo, Stefania Mazzini
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Poly ADP-ribose polymerases (PARP) are key proteins involved in DNA repair, maintenance as well as regulation of programmed cell death. For this reason they are important therapeutic targets for cancer treatment. Recent studies have revealed
Externí odkaz:
https://doaj.org/article/f7228d4c577546f6824be235df0c9bc6
Autor:
Stefania Mazzini, Salvatore Princiotto, Roberto Artali, Loana Musso, Anna Aviñó, Ramon Eritja, Raimundo Gargallo, Sabrina Dallavalle
Publikováno v:
Molecules, Vol 27, Iss 15, p 4792 (2022)
The enzyme PARP1 is an attractive target for cancer therapy, as it is involved in DNA repair processes. Several PARP1 inhibitors have been approved for clinical treatments. However, the rapid outbreak of resistance is seriously threatening the effica
Externí odkaz:
https://doaj.org/article/ced650e78a804ff4bc54c0204b9aa02b
Autor:
Stefania Mazzini, Salvatore Princiotto, Loana Musso, Daniele Passarella, Giovanni Luca Beretta, Paola Perego, Sabrina Dallavalle
Publikováno v:
Molecules, Vol 27, Iss 9, p 2791 (2022)
G-quadruplexes are secondary structures originating from nucleic acid regions rich in guanines, which are well known for their involvement in gene transcription and regulation and DNA damage repair. In recent studies from our group, kynurenic acid (K
Externí odkaz:
https://doaj.org/article/bd178e875e9142b2a9856e3ab67fe0f5
Autor:
Luce Mattio, Loana Musso, Leonardo Scaglioni, Andrea Pinto, Piera Anna Martino, Sabrina Dallavalle
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2482-2487 (2018)
The increasing emergence of multidrug-resistant pathogens is one of the biggest threats to human health and food security. The discovery of new antibacterials, and in particular the finding of new scaffolds, is an imperative goal to stay ahead of the
Externí odkaz:
https://doaj.org/article/56c66b67f88442279e277f5f0e71342d
Autor:
Luce Micaela Mattio, Cecilia Pinna, Giorgia Catinella, Loana Musso, Kasandra Juliet Pedersen, Karen Angeliki Krogfelt, Sabrina Dallavalle, Andrea Pinto
Publikováno v:
Molecules, Vol 26, Iss 24, p 7594 (2021)
The natural stilbenoid dehydro-δ-viniferin, containing a benzofuran core, has been recently identified as a promising antimicrobial agent. To define the structural elements relevant to its activity, we modified the styryl moiety, appended at C5 of t
Externí odkaz:
https://doaj.org/article/c3fd798ee3814434807c7d651afffac1
Autor:
Rahul D. Kaduskar, Giulia Della Scala, Zaaima J. H. Al Jabri, Stefania Arioli, Loana Musso, Marco R. Oggioni, Sabrina Dallavalle, Diego Mora
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Promysalin was previously described as a narrow spectrum molecule with a unique species-specific activity against Pseudomonas aeruginosa. Here we demonstrate that promysalin is active against Gram-positive and Gram-negative bacteria using a
Externí odkaz:
https://doaj.org/article/0dd31ffb6b3f4aeeb329171fd250c465
Autor:
Salvatore Princiotto, Stefania Mazzini, Loana Musso, Fabio Arena, Sabrina Dallavalle, Claudio Pisano
Publikováno v:
Antibiotics, Vol 10, Iss 2, p 126 (2021)
The global increase in infections by multi-drug resistant (MDR) pathogens is severely impacting our ability to successfully treat common infections. Herein, we report the antibacterial activity against S. aureus and E. faecalis (including some MDR st
Externí odkaz:
https://doaj.org/article/c5703eae75e2445e8db38e2a7243446b
Autor:
Atul A. Dhavan, Rahul D. Kaduskar, Loana Musso, Leonardo Scaglioni, Piera Anna Martino, Sabrina Dallavalle
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1624-1628 (2016)
The first total synthesis of leopolic acid A, a fungal metabolite with a rare 2,3-pyrrolidinedione nucleus linked to an ureido dipeptide, was designed and carried out. Crucial steps for the strategy include a Dieckmann cyclization to obtain the 2,3-p
Externí odkaz:
https://doaj.org/article/6c713d2bf17e434aa8f64795ce184cfa