Výsledky vyhledávání - "Loadman, Paul M"

Akademický článek

Effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells.

Autor: Hawcroft, Gillian, Loadman, Paul M., Belluzzi, Andrea, Hull, Mark A.

The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), in the free fatty acid (FFA) form, has been demonstrated to reduce adenoma number and size in patients with familial adenomatous polyposis. However, the mechanistic basis of the anti

Externí odkaz: http://hdl.handle.net/10454/4551

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Akademický článek

Phase 1 Study Of A Sequence Selective Minor Groove DNA Binding Agent (SJG-136) with Pharmacokinetic and Pharmacodynamic Measurements in Patients with Advanced Solid Tumours.

Autor: Hochhauser, Daniel, Meyer, Timothy, Spanswick, Victoria J., Wu, Jenny, Clingen, Peter H., Loadman, Paul M., Cobb, Margaret, Gumbrell, Lindsey, Begent, Richard H., Hartley, J.A., Jodrell, Duncan

PURPOSE: This phase I dose-escalation study was undertaken to establish the maximum tolerated dose of the sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors. The study also investigated antitumor activity

Externí odkaz: http://hdl.handle.net/10454/4564

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Akademický článek

Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate.

Autor: Loadman, Paul M., Bibby, Michael C., Shnyder, Steven D., Swaine, David J., Kirwan, Ian G., Anthoney, Alan, Cooper, Patricia A., Lippert, J.W.

Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical

Externí odkaz: http://hdl.handle.net/10454/2953

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