Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Lo-Kong Chan"'
Autor:
Charles Shing Kam, Daniel Wai-Hung Ho, Vanessa Sheung-In Ming, Lu Tian, Karen Man-Fong Sze, Vanilla Xin Zhang, Yu-Man Tsui, Abdullah Husain, Joyce Man-Fong Lee, Carmen Chak-Lui Wong, Albert Chi-Yan Chan, Tan-To Cheung, Lo-Kong Chan, Irene Oi-Lin Ng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1325-1350 (2023)
Background & Aims: Metabolic reprogramming is recognized as a cancer hallmark intimately linked to tumor hypoxia, which supports rapid tumor growth and mitigates the consequential oxidative stress. Phosphofructokinase-fructose bisphosphatase (PFKFB)
Externí odkaz:
https://doaj.org/article/4caaf380883542f299e658fda3245384
Autor:
Vanilla Xin Zhang, Karen Man-Fong Sze, Lo-Kong Chan, Daniel Wai-Hung Ho, Yu-Man Tsui, Yung-Tuen Chiu, Eva Lee, Abdullah Husain, Hongyang Huang, Lu Tian, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Background Controversy over the benefits of antioxidants supplements in cancers persists for long. Using hepatocellular carcinoma (HCC) as a model, we investigated the effects of exogenous antioxidants N-acetylcysteine (NAC) and glutathione
Externí odkaz:
https://doaj.org/article/a1d03fa0fad84989bbb8f6a0aa46397e
Autor:
Daniel Wai-Hung Ho, Yu-Man Tsui, Lo-Kong Chan, Karen Man-Fong Sze, Xin Zhang, Jacinth Wing-Sum Cheu, Yung-Tuen Chiu, Joyce Man-Fong Lee, Albert Chi-Yan Chan, Elaine Tin-Yan Cheung, Derek Tsz-Wai Yau, Nam-Hung Chia, Irene Lai-Oi Lo, Pak-Chung Sham, Tan-To Cheung, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associat
Externí odkaz:
https://doaj.org/article/f985f3f45e114476aff8ed39645b53e3
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundLines of evidence implicate CENPF and FOXM1 may have novel co-operative roles in driving hepatocellular carcinoma (HCC).ObjectiveWe investigated the clinicopathological correlation, functional characterization, molecular mechanism and trans
Externí odkaz:
https://doaj.org/article/5ce501daf7234e929e561c347eba45d4
Autor:
Jessica Aijia Liu, Yanxia Rao, May Pui Lai Cheung, Man-Ning Hui, Ming-Hoi Wu, Lo-Kong Chan, Irene Oi-Lin Ng, Ben Niu, Kathryn S. E. Cheah, Rakesh Sharma, Louis Hodgson, Martin Cheung
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Following epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localize
Externí odkaz:
https://doaj.org/article/d5afe614c7da4570bdef1328892dfbb0
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25547 (2011)
Deleted in liver cancer 1 (DLC1) serves as an important RhoGTPase activating protein (RhoGAP) protein that terminates active RhoA signaling in human cancers. Increasing evidence has demonstrated that the tumor suppressive activity of DLC1 depends not
Externí odkaz:
https://doaj.org/article/fd4d3c1e004c48558452405b0301b9f8
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5572 (2009)
BACKGROUND:Deleted in liver cancer 1 (DLC1) is a Rho GTPase-activating protein (RhoGAP) frequently deleted and underexpressed in hepatocellular carcinoma (HCC) as well as in other cancers. Recent independent studies have shown interaction of DLC1 wit
Externí odkaz:
https://doaj.org/article/e1cc83fcd7484f31983914489f6416fc
Autor:
Carmen Chak-Lui Wong, Chun-Ming Wong, Frankie Chi-Fat Ko, Lo-Kong Chan, Yick-Pang Ching, Judy Wai-Ping Yam, Irene Oi-lin Ng
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2779 (2008)
Deleted in liver cancer 1 (DLC1), a member of RhoGTPase activating protein (GAP) family, is known to have suppressive activities in tumorigenicity and cancer metastasis. However, the underlying molecular mechanisms of how DLC1 suppresses cell motilit
Externí odkaz:
https://doaj.org/article/64a1cb118aae4298aa162c16ad86b3a4
Autor:
Abdullah Husain, Yung-Tuen Chiu, Karen Man-Fong Sze, Daniel Wai-Hung Ho, Yu-Man Tsui, Eliana Mary Senires Suarez, Vanilla Xin Zhang, Lo-Kong Chan, Eva Lee, Joyce Man-Fong Lee, Tan-To Cheung, Carmen Chak-Lui Wong, Clive Yik-Sham Chung, Irene Oi-Lin Ng
Publikováno v:
Journal of Hepatology. 77:383-396
The highly proliferative nature of hepatocellular carcinoma (HCC) frequently results in a hypoxic intratumoural microenvironment, which creates a therapeutic challenge owing to a lack of mechanistic understanding of the phenomenon. We aimed to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc150c3be83a1e8d8b1a5670db6c538e
https://doi.org/10.1016/j.jhep.2022.02.018
https://doi.org/10.1016/j.jhep.2022.02.018
Publikováno v:
Seminars in Cancer Biology. 82:134-149
Hepatocarcinogenesis involves complex genetic and cellular dysregulations which drive the formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, with extensive heterogeneity. In contrast to the broad spectrum of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2961e1a9b5f1d0794b0499ce7ddfaada
https://doi.org/10.1016/j.semcancer.2021.02.015
https://doi.org/10.1016/j.semcancer.2021.02.015