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Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition

Autor: Sweeney, M., Coyle, R., Kavanagh, P., Berezin, Andrey A., Lo Re, D., Zissimou, Georgia A., Koutentis, Panayiotis Andreas, Carty, Michael P., Aldabbagh, Fawaz

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorg.Med.Chem.

The thioredoxin (Trx)-thioredoxin reductase (TrxR) system plays a key role in maintaining the cellular redox balance with Trx being over-expressed in a number of cancers. Inhibition of TrxR is an important strategy for anti-cancer drug discovery. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bf3c920b9f8e061268f22fae091d54
http://hdl.handle.net/10379/6599

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Advances in paediatric restorative dentistry

Autor: PIZZO, Giuseppe, PIZZO, Ignazio, GIULIANA, Giovanna, Lo Re, D

Dental caries has been a highly prevalent and costly disease in the world, representing the most common infectious disease in the paediatric population. Caries lesions are also increasingly isolated in specific teeth and tooth morphology types, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3658::04e9f2154e8d5edeea04c82389ed85cc
http://hdl.handle.net/10447/41115

Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase

Autor: Catto, M., Berezin, Andrey A., Lo Re, D., Loizou, G., Demetriades, Marina, De Stradis, A., Campagna, F., Koutentis, Panayiotis Andreas, Carotti, A.

Publikováno v: European journal of medicinal chemistry
Eur.J.Med.Chem.
European journal of medicinal chemistry 58 (2012): 84–97. doi:10.1016/j.ejmech.2012.10.003
info:cnr-pdr/source/autori:Catto M., Berezin A.A., Lo Re D., Loizou G., Demetriades M., De Stradis A; Campagna F., Koutentis Panayiotis A., Carotti A./titolo:Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-JK]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl%2Fbutyryl cholinesterase/doi:10.1016%2Fj.ejmech.2012.10.003/rivista:European journal of medicinal chemistry/anno:2012/pagina_da:84/pagina_a:97/intervallo_pagine:84–97/volume:58

Alzheimer's disease (AD) onset and progression are associated with the dysregulation of multiple and complex physiological processes and a successful therapeutic approach should therefore address more than one target. Two new chemical entities, the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669db006d5622f62a9377905de6e19d7
https://pubmed.ncbi.nlm.nih.gov/23108363