Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Loïka Maltais"'
Autor:
Manon Edde, Francis Houde, Guillaume Theaud, Matthieu Dumont, Guillaume Gilbert, Jean-Christophe Houde, Loïka Maltais, Antoine Théberge, Moussa Doumbia, Ann-Marie Beaudoin, Emmanuelle Lapointe, Muhamed Barakovic, Stefano Magon, Maxime Descoteaux
Publikováno v:
NeuroImage: Clinical, Vol 40, Iss , Pp 103529- (2023)
It is currently unknown how quantitative diffusion and myelin MRI designs affect the results of a longitudinal study. We used two independent datasets containing 6 monthly MRI measurements from 20 healthy controls and 20 relapsing-remitting multiple
Externí odkaz:
https://doaj.org/article/9dad6789dc034fd7bcd0a38aae574dc3
Autor:
Loïka Maltais, Martin Montagne, Mikaël Bédard, Cynthia Tremblay, Laura Soucek, Pierre Lavigne
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174413 (2017)
It is classically recognized that the physiological and oncogenic functions of Myc proteins depend on specific DNA binding enabled by the dimerization of its C-terminal basic-region-Helix-Loop-Helix-Leucine Zipper (b-HLH-LZ) domain with that of Max.
Externí odkaz:
https://doaj.org/article/47ee33916a1247eab6532ff7bd65aafa
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 85:199-206
c-Myc is a basic helix-loop-helix leucine zipper (b-HLH-LZ) transcription factor deregulated in the majority of human cancers. As a heterodimer with Max, another b-HLH-LZ transcription factor, deregulated and persistent c-Myc accumulates at transcrip
Autor:
Erika Serrano del Pozo, Christopher Fiore, Miguel Ángel Morcillo Alonso, Loïka Maltais, Sílvia Casacuberta-Serra, Marie-Eve Beaulieu, Danny Létourneau, Laura Soucek, Génesis Martín, Peter B. Rahl, Laia Foradada, Marta Oteo, Sandra Martínez-Martín, Eduardo Romero Sanz, Jonathan Whitfield, Virginia Castillo Cano, Toni Jauset, Matthew G. Guenther, Martin Montagne, Cynthia Tremblay, Meritxell Sánchez-Hervás, Daniel Massó-Vallés, Pierre Lavigne, Mariano F. Zacarias-Fluck
Publikováno v:
Science Translational Medicine
Inhibiting MYC has long been considered unfeasible, although its key role in human cancers makes it a desirable target for therapeutic intervention. One reason for its perceived undruggability was the fear of catastrophic side effects in normal tissu
Publikováno v:
Proteins. 85(2)
c-Myc is a basic helix-loop-helix leucine zipper (b-HLH-LZ) transcription factor deregulated in the majority of human cancers. As a heterodimer with Max, another b-HLH-LZ transcription factor, deregulated and persistent c-Myc accumulates at transcrip
Autor:
Christopher Fiore, Peter B. Rahl, Marta Oteo Vives, Matthew G. Guenther, Daniel Massó-Vallés, Miguel Ángel Morcillo Alonso, Martin Montagne, Sandra Martínez-Martín, Cynthia Tremblay, Pierre Lavigne, Jonathan Whitfield, Mariano F. Zacarias-Fluck, Marie-Eve Beaulieu, Laura Soucek, Loïka Maltais, Laia Foradada, Erika Serrano del Pozo, Toni Jauset, Silvia Casacuberta, Eduardo Romero Sanz
Publikováno v:
Cancer Research. 77:2167-2167
Deregulation of the MYC oncoprotein promotes tumorigenesis in most, if not all, cancers and is often associated with poor prognosis. However, targeting MYC has long been considered impossible based on the assumption that it would cause catastrophic s
Autor:
David N. Bernard, Loïka Maltais, Marie-Eve Beaulieu, Mikaël Bédard, Josée Bilodeau, Pierre Lavigne
Publikováno v:
Journal of biomolecular NMR. 54(3)
Publikováno v:
Molecular Cancer Research. 13:A11-A11
Myc proteins (N-, L- and c-Myc) are transcriptional regulators with a broad spectrum of target genes. While essential for development, cell growth and proliferation as well as apoptosis, they play a major role in cancer onset and progression when der
Autor:
Daniel Massó-Vallés, Erika Serrano, Toni Jauset, Marie-Eve Beaulieu, Laura Soucek, Jonathan Whitfield, Cynthia Tremblay, Loïka Maltais, Martin Montagne, Pierre Lavigne
Publikováno v:
Molecular Cancer Research. 13:PR10-PR10
Deregulated Myc is associated with most human cancers suggesting that its inhibition would be a useful therapeutic strategy. Indeed, we have shown that Myc inhibition displays extraordinary therapeutic benefit in various transgenic mouse models of ca
Autor:
Cynthia Tremblay, Jonathan Whitfield, Marie-Eve Beaulieu, Laura Soucek, Loïka Maltais, Martin Montagne, Toni Jauset, Pierre Lavigne, Erika Serrano del Pozo, Daniel Massó-Vallés
Publikováno v:
Molecular Cancer Research. 13:B23-B23
Inhibiting Myc has long been regarded as a promising cancer treatment. However, clinical Myc inhibition was considered unfeasible due to its central role in normal proliferation and the difficulties of targeting a nuclear transcription factor. The ex