Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Loïc Paulevé"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1011620 (2024)
Boolean networks are largely employed to model the qualitative dynamics of cell fate processes by describing the change of binary activation states of genes and transcription factors with time. Being able to bridge such qualitative states with quanti
Externí odkaz:
https://doaj.org/article/eb908507707547a0a43d0d740a731e61
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background The temporal coordination of biological processes by the circadian clock is an important mechanism, and its disruption has negative health outcomes, including cancer. Experimental and theoretical evidence suggests that the oscilla
Externí odkaz:
https://doaj.org/article/7dfa29a3545e4977a1d106199cad57bc
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Abstract Predicting biological systems’ behaviors requires taking into account many molecular and genetic elements for which limited information is available past a global knowledge of their pairwise interactions. Logical modeling, notably with Boo
Externí odkaz:
https://doaj.org/article/b334f95a292b43fca9da83ea0ae7f1a2
Publikováno v:
Algorithms for Molecular Biology, Vol 12, Iss 1, Pp 1-14 (2017)
Abstract Background Numerous cellular differentiation processes can be captured using discrete qualitative models of biological regulatory networks. These models describe the temporal evolution of the state of the network subject to different competi
Externí odkaz:
https://doaj.org/article/c8166175daa440a9a3e30c8e97f22dac
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8837e014d8e94b858c30bb4503e6e3b8
Autor:
Misbah Razzaq, Loïc Paulevé, Anne Siegel, Julio Saez-Rodriguez, Jérémie Bourdon, Carito Guziolowski
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 10, p e1006538 (2018)
Protein signaling networks are static views of dynamic processes where proteins go through many biochemical modifications such as ubiquitination and phosphorylation to propagate signals that regulate cells and can act as feed-back systems. Understand
Externí odkaz:
https://doaj.org/article/dd641583953a42aba07201dfa4230365
Autor:
Nicolas Levy, Aurélien Naldi, Céline Hernandez, Gautier Stoll, Denis Thieffry, Andrei Zinovyev, Laurence Calzone, Loïc Paulevé
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Boolean and multi-valued logical formalisms are increasingly used to model complex cellular networks. To ease the development and analysis of logical models, a series of software tools have been proposed, often with specific assets. However, combinin
Externí odkaz:
https://doaj.org/article/73d2481eef3c427ab3f0e5a1609afda5
Autor:
Aurélien Naldi, Céline Hernandez, Nicolas Levy, Gautier Stoll, Pedro T. Monteiro, Claudine Chaouiya, Tomáš Helikar, Andrei Zinovyev, Laurence Calzone, Sarah Cohen-Boulakia, Denis Thieffry, Loïc Paulevé
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Analysing models of biological networks typically relies on workflows in which different software tools with sensitive parameters are chained together, many times with additional manual steps. The accessibility and reproducibility of such workflows i
Externí odkaz:
https://doaj.org/article/9a2d4dac80934cea9cb3c36fd1316bdf
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 40, Iss Proc. MeCBIC 2010, Pp 1-5 (2010)
Biological systems typically involve large numbers of components with complex, highly parallel interactions and intrinsic stochasticity. To model this complexity, numerous programming languages based on process calculi have been developed, many of wh
Externí odkaz:
https://doaj.org/article/2dd826c4dc1e4b80aa896f2d38217edc
Autor:
Jorgelindo da Veiga Moreira, Minoo Hamraz, Mohammad Abolhassani, Erwan Bigan, Sabine Pérès, Loïc Paulevé, Marcel Levy Nogueira, Jean-Marc Steyaert, Laurent Schwartz
Publikováno v:
Metabolites, Vol 6, Iss 4, p 33 (2016)
To better understand the energetic status of proliferating cells, we have measured the intracellular pH (pHi) and concentrations of key metabolites, such as adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD), and nicotinamide adeni
Externí odkaz:
https://doaj.org/article/93d7ac790bad421f883c8ef670c569d5