Connexin37‐Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II‐Mediated Hypertension

Autor: Loïc Le Gal, Maxime Pellegrin, Tania Santoro, Lucia Mazzolai, Armin Kurtz, Paolo Meda, Charlotte Wagner, Jacques‐Antoine Haefliger

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 8 (2019)

Background Gap junction channels made of Connexin37 (Cx37) are expressed by aortic endothelial and smooth muscle cells of hypertensive mice, as well as by the renin‐secreting cells of kidneys. Methods and Results To decipher whether Cx37 has any ro

Externí odkaz: https://doaj.org/article/a237c2aead0840e28fdf9fe8a7569937

Targeting Cx40 (Connexin40) Expression or Function Reduces Angiogenesis in the Developing Mouse Retina

Autor: Denise Nardelli-Haefliger, Elisabeth Génot, Florent Allagnat, Lauriane Hamard, Loïc Le Gal, Paolo Meda, Jacques-Antoine Haefliger, Florian Alonso

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37:2136-2146

Objective— Cx40 (Connexin40) forms intercellular channels that coordinate the electric conduction in the heart and the vasomotor tone in large vessels. The protein was shown to regulate tumoral angiogenesis; however, whether Cx40 also contributes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cef0a7c6b0b4d0e4d8fed9f51b69160
https://doi.org/10.1161/atvbaha.117.310072

Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells

Autor: Loïc Le Gal, Eric Raddatz, Jessica Sabourin, Florent Allagnat, Jacques-Antoine Haefliger, Lisa Saurwein

Publikováno v: The Journal of biological chemistry

Store-operated Ca(2+) channels (SOCs) are voltage-independent Ca(2+) channels activated upon depletion of the endoplasmic reticulum Ca(2+) stores. Early studies suggest the contribution of such channels to Ca(2+) homeostasis in insulin-secreting panc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e98737de34734d6c0f899bb367e483
https://doi.org/10.1074/jbc.m115.682583

Connexins and M3 muscarinic receptors contribute to heterogeneous Ca(2+) signaling in mouse aortic endothelium

Autor: Jean-Louis Bény, Jacques-Antoine Haefliger, François-Xavier Boittin, Loïc Le Gal, Florian Alonso, Florent Allagnat

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology bi
Cellular physiology and biochemistry, vol. 31, no. 1, pp. 166-178
Cellular Physiology and Biochemistry, Vol 31, Iss 1, Pp 166-178 (2013)

BACKGROUND/AIMS Smooth muscle tone is controlled by Ca(2+) signaling in the endothelial layer. Mouse endothelial cells are interconnected by gap junctions made of Connexin40 (Cx40) and Cx37 which allow the exchange of signaling molecules to coordinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02d6f615050f62607fd6395e5dd8556
http://www.snf.ch

Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion

Autor: Laurent Derré, Patrice Jichlinski, Paolo Meda, Loïc Le Gal, Jacques-Antoine Haefliger, Florian Alonso, Sonia Domingos-Pereira, Denise Nardelli-Haefliger

Publikováno v: Oncotarget, vol. 7, no. 12, pp. 14015-14028
Oncotarget

// Florian Alonso 1, * , Sonia Domingos-Pereira 2, * , Loic Le Gal 1 , Laurent Derre 2 , Paolo Meda 3 , Patrice Jichlinski 2 , Denise Nardelli-Haefliger 2, # , Jacques-Antoine Haefliger 1, # 1 Department of Medicine, Lausanne University Hospital, Lau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4ce2f54cce7982cd9b5431f87bde5f
https://serval.unil.ch/resource/serval:BIB_42D2A2696272.P001/REF.pdf