Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Loïc Carrique"'
Autor:
Ecco Staller, Loïc Carrique, Olivia C. Swann, Haitian Fan, Jeremy R. Keown, Carol M. Sheppard, Wendy S. Barclay, Jonathan M. Grimes, Ervin Fodor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear
Externí odkaz:
https://doaj.org/article/00ffc1857d274ff1aec0d37f48d9400f
Autor:
Jeremy R. Keown, Adam D. Crawshaw, Jose Trincao, Loïc Carrique, Richard J. Gildea, Sam Horrell, Anna J. Warren, Danny Axford, Robin Owen, Gwyndaf Evans, Annie Bézier, Peter Metcalf, Jonathan M. Grimes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Infectious protein crystals are an essential part of the viral lifecycle for double-stranded DNA Baculoviridae and double-stranded RNA cypoviruses. These viral protein crystals, termed occlusion bodies or polyhedra, are dense protein assembl
Externí odkaz:
https://doaj.org/article/52663ececd974c08bbcf8a519f0e1636
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies
Autor:
Jeremy R. Keown, Zihan Zhu, Loïc Carrique, Haitian Fan, Alexander P. Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M. Grimes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Influenza viruses carry their own RNAdependent RNA-polymerase that is highly conserved and a promising anti-viral target. Combining functional and structural data, Keown et al. characterise the inhibitory effect of nanobodies on 1918 pandemic H1N1 in
Externí odkaz:
https://doaj.org/article/7162090586c140f3b1741bc087eb5d6f
Autor:
Max Renner, Wanwisa Dejnirattisai, Loïc Carrique, Itziar Serna Martin, Dimple Karia, Serban L. Ilca, Shu F. Ho, Abhay Kotecha, Jeremy R. Keown, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here, the authors provide cryo-EM structures of mature and immature Spondweni virus, defining the furin recognition site at high resolution, and identifying a lipid that binds E upon capsid maturation and is also present in Zika and Dengue virions.
Externí odkaz:
https://doaj.org/article/c1e60ed8086c474ea0ccecd7e38b5686
Autor:
Loïc Carrique, Lionel Ballut, Arpit Shukla, Neelakshi Varma, Resmi Ravi, Sébastien Violot, Bharath Srinivasan, Umesh Tippagondanahalli Ganeshappa, Sonia Kulkarni, Hemalatha Balaram, Nushin Aghajari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in t
Externí odkaz:
https://doaj.org/article/c632ca110e894c0abfd98854ea286089
Autor:
Lionel Ballut, Sébastien Violot, Frédéric Galisson, Isabelle R. Gonçalves, Juliette Martin, Santosh Shivakumaraswamy, Loïc Carrique, Hemalatha Balaram, Nushin Aghajari
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 871 (2022)
Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the addition of nitrog
Externí odkaz:
https://doaj.org/article/e14715547f034e78a813fc741f41d19d
Autor:
Urvashi Sharma, Loïc Carrique, Sandrine Vadon-Le Goff, Natacha Mariano, Rainier-Numa Georges, Frederic Delolme, Peppi Koivunen, Johanna Myllyharju, Catherine Moali, Nushin Aghajari, David J. S. Hulmes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen
Externí odkaz:
https://doaj.org/article/a60a8ed5f31b4d4886df090a13228cae
Autor:
Lionel Ballut, Sébastien Violot, Frédéric Galisson, Isabelle R. Gonçalves, Juliette Martin, Santosh Shivakumaraswamy, Loïc Carrique, Hemalatha Balaram, Nushin Aghajari
Publikováno v:
Biomolecules; Volume 12; Issue 7; Pages: 871
Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the addition of nitrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec83a66b85f496d3fd3d1b5cf730119
https://doi.org/10.3390/biom12070871
https://doi.org/10.3390/biom12070871
Autor:
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M. E. Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, E. Yvonne Jones
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The Wnt receptor Frizzled3 (FZD3) is important for brain axonal development and cancer progression. We report structures of FZD3 in complex with extracellular and intracellular binding nanobodies (Nb). The crystal structure of Nb8 in complex
Externí odkaz:
https://doaj.org/article/c600bbcc0576464685448dff366e8f2a
Autor:
T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution
Externí odkaz:
https://doaj.org/article/cf3afb5f6f044bce9bcb06b11105b64c