Protein overabundance is driven by growth robustness

Autor: Choi, H. James, Lo, Teresa W., Cutler, Kevin J., Huang, Dean, Will, W. Ryan, Wiggins, Paul A.

Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes; whereas overexpression slows growth by increasing the metabolic load. This trade-off naively pred

Externí odkaz: http://arxiv.org/abs/2408.11952

The one-message-per-cell-cycle rule: A conserved minimum transcription level for essential genes

Autor: Lo, Teresa W., Choi, Han Kyou James, Huang, Dean, Wiggins, Paul A.

The inherent stochasticity of cellular processes leads to significant cell-to-cell variation in protein abundance. Although this noise has already been characterized and modeled, its broader implications and significance remain unclear. In this paper

Externí odkaz: http://arxiv.org/abs/2307.03324

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Protein overabundance is driven by growth robustness.

Autor: Choi HJ; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Lo TW; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Cutler KJ; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Huang D; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Will WR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195, USA., Wiggins PA; Department of Physics, University of Washington, Seattle, Washington 98195, USA.; Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.; Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA.

Publikováno v: ArXiv [ArXiv] 2024 Aug 21. Date of Electronic Publication: 2024 Aug 21.

The one-message-per-cell-cycle rule: A conserved minimum transcription level for essential genes.

Autor: Lo TW; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Choi HKJ; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Huang D; Department of Physics, University of Washington, Seattle, Washington 98195, USA., Wiggins PA; Department of Physics, University of Washington, Seattle, Washington 98195, USA.; Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA.; Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 07. Date of Electronic Publication: 2023 Jul 07.