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Deep learning-based polygenic risk analysis for Alzheimer's disease prediction.

Autor: Zhou X; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China., Chen Y; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China.; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, 518055, China., Ip FCF; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China., Jiang Y; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China., Cao H; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Lv G; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Zhong H; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China., Chen J; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Ye T; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China.; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, 518055, China., Chen Y; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China.; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, 518055, China., Zhang Y; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China., Ma S; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China., Lo RMN; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Tong EPS; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Mok VCT; Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China., Kwok TCY; Therese Pei Fong Chow Research Centre for Prevention of Dementia, Division of Geriatrics, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China., Guo Q; Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China., Mok KY; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK., Shoai M; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK., Hardy J; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; HKUST Jockey Club Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Chen L; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Fu AKY; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China., Ip NY; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. boip@ust.hk.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China. boip@ust.hk.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China. boip@ust.hk.

Publikováno v: Communications medicine [Commun Med (Lond)] 2023 Apr 06; Vol. 3 (1), pp. 49. Date of Electronic Publication: 2023 Apr 06.

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.

Autor: Zhou X; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China., Chen Y; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.; The Brain Cognition and Brain Disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong China., Ip FCF; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China., Lai NCH; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Li YYT; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Jiang Y; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Zhong H; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Chen Y; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China., Zhang Y; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China., Ma S; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China., Lo RMN; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Cheung K; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Tong EPS; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Ko H; Division of Neurology Department of Medicine and Therapeutics Li Ka Shing Institute of Health Sciences School of Biomedical Sciences Gerald Choa Neuroscience Center Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong China., Shoai M; Department of Neurodegenerative Disease UCL Institute of Neurology London UK., Mok KY; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.; Department of Neurodegenerative Disease UCL Institute of Neurology London UK., Hardy J; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.; Department of Neurodegenerative Disease UCL Institute of Neurology London UK.; Institute for Advanced Study The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China., Mok VCT; Gerald Choa Neuroscience Centre Lui Che Woo Institute of Innovative Medicine Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Neurology Department of Medicine and Therapeutics The Chinese University of Hong Kong Shatin Hong Kong China., Kwok TCY; Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Geriatrics Department of Medicine and Therapeutics The Chinese University of Hong Kong Shatin Hong Kong China., Fu AKY; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China., Ip NY; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2020 Aug 05; Vol. 12 (1), pp. e12074. Date of Electronic Publication: 2020 Aug 05 (Print Publication: 2020).