Výsledky vyhledávání - "Ln, Shishkina"

[EVALUATION OF THE HUMAN SENSITIVITY TO SMALLPOX VIRUS BY THE PRIMARY CULTURES OF THE MONOCYTE-MACROPHAGES]

Autor: As, Zamedyanskaya, Ka, Titova, Aa, Sergeev, As, Kabanov, Le, Bulychev, Do, Galakhova, Ae, Nesterov, Ov, Nosareva, Ln, Shishkina, Oleg Taranov, Vv, Omigov, Ap, Agafonov, An, Sergeev

Publikováno v: Europe PubMed Central

Studies of the primary cultures of granulocytes, mononuclear, and monocyte-macrophage cells derived from human blood were performed using variola virus (VARV) in the doses of 0.001-0.021 PFU/cell (plaques-forming units per cell). Positive dynamics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b7c5441b68b3f418d53996fd096fd555
https://pubmed.ncbi.nlm.nih.gov/27451498

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[Development of the disease in marmot at the intranasal infection with the monkeypox virus]

Autor: Aa, Sergeev, As, Kabanov, Le, Bulychev, Ov, Pyankov, Sa, Bodnev, Do, Galakhova, As, Zamedyanskaya, Ka, Titova, Ln, Shishkina, Ap, Agafonov, An, Sergeev

Publikováno v: Europe PubMed Central

In experimental study the sensitivity of the Marmota bobak species to the monkeypox virus (MPXV) with the intranasal (i/n) infection was tested. It was demonstrated that 50% of the infective dose (ID50) of the MPXV on external clinical signs of the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::afbe2e3a82333647139405c9121f0dda
https://pubmed.ncbi.nlm.nih.gov/27024916

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[A comparative study of the antiviral activity of chemical compounds concerning the orthopoxviruses experiments in vivo]

Autor: As, Kabanov, Aa, Sergeev, Ln, Shishkina, Le, Bulychev, Mo, Skarnovich, Ni, Bormotov, Iankov Ov, P., Oa, Serova, Sa, Bodnev, Ba, Selivanov, Tikhonov AIa, Ap, Agafonov, An, Sergeev

Publikováno v: Europe PubMed Central

In the experiments using intranasal (i/n) infection of mice with the ectromelia virus (EV) in a dose 10 LD50/head (10 x 50% lethal doselhead) or with the monkaypox virus (MPXV) in a dose 10 ID50/head (10 x 50% infective dose/ head) it was demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a83a2a7ec940d46b028fe78b32e940fa
https://pubmed.ncbi.nlm.nih.gov/24354064

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[In vitro and in vivo efficacy of Ingavirin against strains of pandemic influenza virus A(H1N1/09)v]

Autor: Ln, Shishkina, Ve, Nebol Sin, As, Kabanov, Mo, Skarnovich, Na, Mazurkova, Artemiy Sergeev, Oa, Serova, Ea, Stavskiĭ, Ig, Drozdov

Publikováno v: Europe PubMed Central
Artemiy Sergeev

To study efficacy of Ingavirin in vitro and in vivo against strains of pandemic influenza virus A(H1N1/09)v and influenza virus A(H5N1) and A(H3N2).Changes in hemagglutinating and cytopathic activity of influenza virus strains A(H1N1/09)v, A(H5N1) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5d187ece966d5b87fffd062e58ad5203
https://pubmed.ncbi.nlm.nih.gov/21598625

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[Validation of the modified algorithm for predicting host susceptibility to viruses taking into account susceptibility parameters of primary target cell cultures and natural immunity factors]

Autor: Va, Zhukov, Ln, Shishkina, As, Safatov, Aa, Sergeev, Iankov Ov, P., Va, Petrishchenko, Bn, Zaĭtsev, Vs, Toporkov, An, Sergeev, Nesvizhskiĭ IuV, Aa, Vorob Ev

Publikováno v: Europe PubMed Central

The paper presents results of testing a modified algorithm for predicting virus ID50 values in a host of interest by extrapolation from a model host taking into account immune neutralizing factors and thermal inactivation of the virus. The method was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd0fbc948b76a05b8e605d16fb53de33
https://pubmed.ncbi.nlm.nih.gov/20608042

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[A study of possibility to predict the sensitivity of different respiratory tract divisions to influenza]

Autor: Va, Zhukov, Ln, Shishkina, Aa, Sergeev, Iv, Fankin, Ma, Smetannikova, Iankov Ov, P., Va, Petrishchenko, An, Sergeev, Aa, Vorob Ev

Publikováno v: Europe PubMed Central

To predict a potential value of a viral ID50 for a macro-organism of interest (e.g. humans), it is necessary to determine in vitro two parameters of the interaction of the virus with susceptible cells of the host, i.e. the probability of the virus' p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::25d391ca17af8a18e08d1eb72a6edbdc
https://pubmed.ncbi.nlm.nih.gov/17601039

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[Target-cell susceptibility and lung phagocyte activity in mice with influenza virus resistance lowered by glucocorticoidal immunosuppression]

Autor: Ma, Smetannikova, Ln, Shishkina, Va, Zhukov, Iv, Fankin, Aa, Sergeev, Mo, Skarnovich, Iankov Ov, P., Va, Petrishchenko, Vn, Bondarenko, An, Sergeev

Publikováno v: Europe PubMed Central

The results of the study showed that subcutaneous kenalog (Kn) lowered the resistance of mice to influenza virus (InV), as was seen by a decrease in 50% lethal dose and an increase in the degree of pulmonary tissue lesion, and the susceptibility of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f198c3ef388afe4e5c0058b533890bf8
https://pubmed.ncbi.nlm.nih.gov/17338373

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[Clinical trials of oral recombinant bivaccine against variola and hepatitis B during double vaccination]

Autor: Iv, Pliasunov, An, Sergeev, Aa, Sergeev, Va, Petrishchenko, Ln, Shishkina, Vv, Generalov, As, Safatov, Ls, Sandakhchiev, Vv, Udut, Sa, Mel Nikov, Vn, Podkuĭko

Publikováno v: Europe PubMed Central

Clinical trials of oral live recombinant embryonic variola and hepatitis B bivaccine as tablets (Revax-BT) were performed. When volunteers were prevaccinated with oral variola vaccine first in a small dose and, 7, 14, 30, 90, and 180 days later, in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::81bf532832bc35ca63052b8357f79128
https://pubmed.ncbi.nlm.nih.gov/16756176

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[Reactogenicity, safety and immunogenicity of a recombinant bivaccine against smallpox and hepatitis B in limited clinical trials]

Autor: Aa, Sergeev, An, Sergeev, Va, Petrishchenko, Ln, Shishkina, Gv, Kochneva, Va, Zhukov, Nk, Evtin, Iankov Ov, P., Ls, Sandakhchiev, La, Akinfeeva, Vv, Udut, Sherstoboev EIu, Ed, Gol Dberg, Sa, Mel Nikov, Vn, Podkuĭko, Va, Maksimov

Publikováno v: Europe PubMed Central

The reactogenicity of the embryonic live recombinant variola and hepatitis B bivaccine as tablets (Revax-BT) as well as its safety and immunogenicity were evaluated in clinical trials made in volunteers who had previously immunized or not with variol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4c72912015d7fc84600e23ec357ffd8a
https://pubmed.ncbi.nlm.nih.gov/15529859

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[A new setup for the generation and studies of mono-disperse microbiological aerosols in medical-and-biological research]

Autor: Va, Zhukov, As, Safatov, Iankov Ov, P., Vs, Toporkov, Aa, Sergeev, Sa, Kiselev, Va, Iashin, Nm, Beliaev, Ei, Riabchikova, Av, Zhukov, Ln, Shishkina, Aa, Medvedev, Va, Petrishchenko, An, Sergeev, Aa, Vorob Ev

Publikováno v: Europe PubMed Central

A setup for the generation and studies of mono-disperse microbiological aerosols is described in the paper. Coefficients of 3 microm aerosol deposition in the respiratory tract of mice and rats were refined by using the above setup. The probability o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2ad909dc15d6b48f7419f42420112669
https://pubmed.ncbi.nlm.nih.gov/15455684

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