Výsledky vyhledávání - "Lm, Chelstrom"

In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor

Autor: Jp, Perentesis, Gunther R, Waurzyniak B, Yanishevski Y, Myers DE, Ek O, Messinger Y, Shao Y, Lm, Chelstrom, Schneider E, We, Evans, Fatih M. Uckun

Publikováno v: Europe PubMed Central

Acute myeloid leukemia (AML) is the most common form of acute leukemia. Contemporary chemotherapy regimens fail to cure most patients with AML. We have genetically engineered a recombinant diphtheria toxin human granulocyte macrophage colony-stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b6bd0cd53138ab0548720a8a12d5f86b
https://pubmed.ncbi.nlm.nih.gov/9815618

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Treatment of human B-cell precursor leukemia in SCID mice using a combination of the investigational biotherapeutic agent B43-PAP with cytosine arabinoside

Autor: Messinger Y, Yanishevski Y, Vi, Avramis, Ek O, Lm, Chelstrom, Gunther R, Myers DE, Jd, Irvin, Evans W, Fatih M. Uckun

Publikováno v: Europe PubMed Central

Combined immunochemotherapy regimens using the investigational biotherapeutic agent B43(anti-CD19)-poke-weed antiviral protein (PAP) immunotoxin may offer an effective treatment for refractory B-cell precursor leukemias. The purpose of the present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d9b517f5ee8188f523b90a328c5b00e9
https://pubmed.ncbi.nlm.nih.gov/9816330

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In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells

Autor: Kg, Waddick, Myers DE, Gunther R, Lm, Chelstrom, Chandan-Langlie M, Jd, Irvin, Tumer N, Fatih M. Uckun

Publikováno v: Europe PubMed Central

B-cell precursor (BCP) leukemia is the most common form of childhood cancer and represents one of the most radiation-resistant forms of human malignancy. In this study, we examined the antileukemic efficacy of the B43 (anti-CD19)-pokeweed antiviral p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d8fcf041eff965654984fae910b4bc6a
https://pubmed.ncbi.nlm.nih.gov/7492781

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In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells

Autor: Fatih M. Uckun, Cf, Stewart, Reaman G, Lm, Chelstrom, Jin J, Chandan-Langlie M, Kg, Waddick, White J, We, Evans

Publikováno v: Europe PubMed Central

Topotecan [(S)-9-dimethylaminomethyl-10-hydroxycamptothecin hydrochloride; SKF 104864-A, NSC 609699], a water soluble semisynthetic analogue of the alkaloid camptothecin, is a potent topoisomerase I inhibitor. Here we show that topotecan stabilizes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dfc14065abc4b752b3badc0f7cb50bac
https://pubmed.ncbi.nlm.nih.gov/7742543

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Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin

Autor: Gunther R, Lm, Chelstrom, Tuel-Ahlgren L, Simon J, Myers DE, Fatih M. Uckun

Publikováno v: Europe PubMed Central

The study of central nervous system (CNS) leukemia has been hampered by the lack of a suitable animal model. We report that severe combined immunodeficiency (SCID) mice invariably develop rapidly progressive fatal CNS leukemia within 3 weeks after in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3124dfe52ea98d6c0664294c5c164066
https://pubmed.ncbi.nlm.nih.gov/7537120

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Human t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency

Autor: Fatih M. Uckun, Jr, Downing, Gunther R, Lm, Chelstrom, Finnegan D, Vj, Land, Mj, Borowitz, Aj, Carroll, Wm, Crist

Publikováno v: Europe PubMed Central

Severe combined immunodeficient (SCID) mice were injected intravenously with 5 x 10(6) primary bone marrow (BM) blasts from newly diagnosed patients with E2A-PBX1 fusion transcript positive t(1;19)(q23;p13) pre- B acute lymphoblastic leukemia (ALL).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf238ac26c63a3fd91aba90234a0051
https://pubmed.ncbi.nlm.nih.gov/8098968

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Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide

Autor: Fatih M. Uckun, Lm, Chelstrom, Finnegan D, Tuel-Ahlgren L, Manivel C, Jd, Irvin, Myers DE, Gunther R

Publikováno v: Europe PubMed Central

A highly aggressive human CALLA+C mu+ pre-B acute lymphoblastic leukemia (ALL) cell line (NALM-6-UM1) causes disseminated and invariably fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). We used this SCID mouse model of human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f77e86ba73982b0bf188f93f51074dc
https://pubmed.ncbi.nlm.nih.gov/1375841

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In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency

Autor: Fatih M. Uckun, Manivel C, Arthur D, Lm, Chelstrom, Finnegan D, Tuel-Ahlgren L, Jd, Irvin, Myers DE, Gunther R

Publikováno v: Europe PubMed Central

A highly aggressive subclone of the human CALLA+C mu+ pre-B acute lymphoblastic leukemia (ALL) cell line NALM-6 (designated NALM-6-UM1) caused disseminated and fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). An intravenous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589fe35d793ccfdc128a860b306034ad
http://europepmc.org/abstract/med/1373967

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In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor

Autor: Fatih M. Uckun, Rk, Narla, Zeren T, Yanishevski Y, Myers DE, Waurzyniak B, Ek O, Schneider E, Messinger Y, Lm, Chelstrom, Gunther R, Evans W

Publikováno v: Europe PubMed Central

Epidermal growth factor receptor (EGFR)-associated protein tyrosine kinase (PTK) complexes have vital anti-apoptotic functions in human breast cancer cells. We have shown previously that targeting the naturally occurring PTK inhibitor genistein to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4937d65ba08f2ebd258780974479aafd
http://europepmc.org/abstract/med/9607569

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In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia

Autor: Fatih M. Uckun, Lm, Chelstrom, Jd, Irvin, Finnegan D, Gunther R, Young J, Kuebelbeck V, Myers DE, Ll, Houston

Publikováno v: Europe PubMed Central

We show that a highly aggressive subclone of murine BCL-1 B-lineage leukemia expresses a single 2.4-kb transcript hybridizing to the human CD19 cDNA probe and reacts strongly with the anti-human CD19 monoclonal antibodies (MoAb) B43, B4, Leu-12, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd92128451ff44990259826834dc4f48
http://europepmc.org/abstract/med/1375109

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