High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Autor: Cristina Díaz-Perlas, Benjamin Ricken, Lluc Farrera-Soler, Dmitrii Guschin, Florence Pojer, Kelvin Lau, Christian-Benedikt Gerhold, Christian Heinis

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Common inflammatory disorders such as ulcerative colitis and Crohn’s disease are non-invasively diagnosed or monitored by the biomarker calprotectin. However, current quantitative tests for calprotectin are antibody-based and vary dependin

Externí odkaz: https://doaj.org/article/061fa9cf243f4870a024c34ddcd4e9e5

Pseudo-Complementary G:C Base Pair for Mixed Sequence dsDNA Invasion and Its Applications in Diagnostics (SARS-CoV-2 Detection)

Autor: Miguel López-Tena, Lluc Farrera-Soler, Sofia Barluenga, Nicolas Winssinger

Publikováno v: JACS Au. 3:449-458

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a35b4bde9bf03c692baff16d5827ad4f
https://doi.org/10.1021/jacsau.2c00588

A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules

Autor: Balayeshwanth R. Vummidi, Lluc Farrera-Soler, Jean-Pierre Daguer, Millicent Dockerill, Sofia Barluenga, Nicolas Winssinger

Publikováno v: Nature chemistry, Vol. 14, No 2 (2022) pp. 141-152

DNA-encoded library technologies empower the screening of synthetic molecules but have thus far not tapped into the power of Darwinian selection with iterative cycles of selection, amplification and diversification. Herein we report a simple strategy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb869c587d22fd10bc71742b1762c7dd
https://doi.org/10.1038/s41557-021-00829-5

Combining recombinase polymerase amplification and DNA-templated reaction for SARS-CoV-2 sensing with dual fluorescence and lateral flow assay output

Autor: Lluc Farrera‐Soler, Arthur Gonse, Ki Tae Kim, Sofia Barluenga, Nicolas Winssinger

Publikováno v: Biopolymers, Vol. 113, No 4 (2022) P. e23485

The early phase of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic was exacerbated by a diagnostic challenge of unprecedented magnitude. In the absence of effective therapeutics or vaccines, breaking the chain of transmissio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff3c09187036b81634feda3937b0631
https://pubmed.ncbi.nlm.nih.gov/35023571

SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1

Autor: Jean-Pierre Daguer, Noémie Suh, Catherine Juillard, Nicolas Vuilleumier, Oliver Hartley, Sabine Yerly, Isabella Eckerle, Laurent Kaiser, Barbara Lemaître, Idris Guessous, Giovanni Piumatti, Christiane S. Eberhardt, Jérôme Pugin, Claire-Anne Siegrist, Nicolas Winssinger, Benjamin Meyer, Lluc Farrera-Soler, Christophe Le Terrier, Silvia Stringhini, Sofia Barluenga, Sabrina Pagano

Publikováno v: European Journal of Clinical Investigation
EAS Congress 2021, Vol. 331 (2021) P. e78
Atherosclerosis
European Journal of Clinical Investigation, Vol. 51, No 11 (2021) P. e13661

Background Unravelling autoimmune targets triggered by SARS‐CoV‐2 infection may provide crucial insights into the physiopathology of the disease and foster the development of potential therapeutic candidate targets and prognostic tools. We aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c425078002e1a24d7c4711930d396e3
http://europepmc.org/articles/PMC8420318