Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Lluís Miquel-Rio"'
1
Akademický článek
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related neurodegenerative deficits
Autor: Ariadna Laguna, Núria Peñuelas, Marta Gonzalez-Sepulveda, Alba Nicolau, Sébastien Arthaud, Camille Guillard-Sirieix, Marina Lorente-Picón, Joan Compte, Lluís Miquel-Rio, Helena Xicoy, Jiong Liu, Annabelle Parent, Thais Cuadros, Jordi Romero-Giménez, Gemma Pujol, Lydia Giménez-Llort, Patrice Fort, Analia Bortolozzi, Iria Carballo-Carbajal, Miquel Vila
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neur
Externí odkaz: https://doaj.org/article/de9a8ae5677146419f7bcb8a1fa18b31
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2
Akademický článek
Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine
Autor: Mireia Tarrés-Gatius, Lluís Miquel-Rio, Leticia Campa, Francesc Artigas, Anna Castañé
Publikováno v: Translational Psychiatry, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Acute ketamine administration evokes rapid and sustained antidepressant effects in treatment-resistant patients. However, ketamine also produces transient perceptual disturbances similarly to those evoked by other non-competitive NMDA-R anta
Externí odkaz: https://doaj.org/article/06b33218917b4cebb32f09ee0a240a19
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4
Up-And-Down γ-Synuclein Transcription in Dopamine Neurons Translates Into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice
Autor: Rubén Pavia-Collado, Raquel Rodríguez-Aller, Diana Alarcón-Arís, Lluís Miquel-Rio, Esther Ruiz-Bronchal, Verónica Paz, Leticia Campa, Mireia Galofré, Véronique Sgambato, Analia Bortolozzi
The synuclein family consists of α-, β-, and γ-Synuclein (α-Syn, β-Syn, and γ-Syn), expressed in the neurons and concentrated in synaptic terminals. While α-Syn is at the center of interest due to its implication in the pathogenesis of Parkins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd716ebf41c4fe88479ad43fea96e6bc
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5
Dual 5-HT3 and 5-HT6 Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats
Autor: Anna Castañé, Montserrat Cano, Luis Ruiz-Avila, Lluís Miquel-Rio, Pau Celada, Francesc Artigas, Maurizio S Riga
Publikováno v: The international journal of neuropsychopharmacology. 25(5)
Schizophrenia is a severe mental disorder featuring psychotic, depressive, and cognitive alterations. Current antipsychotic drugs preferentially target dopamine D2-R and/or serotonergic 5-HT2A/1A-R. They partly alleviate psychotic symptoms but fail t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44cf8473a5cbef363ac975696195672
https://pubmed.ncbi.nlm.nih.gov/35022720
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6
Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice
Autor: Rubén Pavia-Collado, Andrés Montefeltro, Lluís Miquel-Rio, Raquel Revilla, Verónica Paz, María Torres-López, Francesc Artigas, Leticia Campa, Raquel Rodriguez-Aller, Analía Bortolozzi, Valentín Coppola-Segovia, Esther Ruiz-Bronchal, Diana Alarcón-Aris
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2939, p 2939 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
Digital.CSIC. Repositorio Institucional del CSIC
instname
α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications of the α-Syn, which encodes the SNCA gene, are correlated with early-onset PD, therefore the reduction in a-Syn synthesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5505f8e391423c0b85ee19ee2af507b4
http://hdl.handle.net/10261/265690
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7
Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys
Autor: Diana Alarcón-Arís, Mireia Galofré, Analía Bortolozzi, Verónica Paz, Lluís Miquel-Rio, Rubén Pavia-Collado, Andrés Montefeltro, Valentín Coppola-Segovia, Miquel Vila, Raquel Revilla, Francesc Artigas, Albert Ferrés-Coy, Leticia Campa, Esther Ruiz-Bronchal, Jeffrey H. Kordower
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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EBioMedicine, Vol 59, Iss, Pp 102944-(2020)
EBioMedicine
Background: Progressive neuronal death in monoaminergic nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that α-synuclein may be an early mediator of the pathological cascade that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb35670fac82578dfae34af3da951ee
http://hdl.handle.net/10261/223696
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9
Akademický článek
ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling
Autor: Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozzi
Publikováno v: iScience, Vol 27, Iss 5, Pp 109787- (2024)
Summary: Depression is a devastating mood disorder that causes significant disability worldwide. Current knowledge of its pathophysiology remains modest and clear biological markers are lacking. Emerging evidence from human and animal models reveals
Externí odkaz: https://doaj.org/article/56dc01babd3f401aaa626f26a9ef070d
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