Výsledky vyhledávání - "Lluís Millán-Ariño"

Specificities and genomic distribution of somatic mammalian histone H1 subtypes

Autor: Albert Jordan, Lluís Millán-Ariño, Andrea Izquierdo-Bouldstridge

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859:510-519

Histone H1 is a structural component of chromatin that may have a role in the regulation of chromatin dynamics. Unlike core histones, the linker histone H1 family is evolutionarily diverse and many organisms have multiple H1 variants or subtypes, dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbdcd1e6c85f4d64d0b4cf306a9ff20
https://doi.org/10.1016/j.bbagrm.2015.10.013

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Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats

Autor: Albert Jordan, Manel Esteller, Patricia Aribau-Miralbés, Anna Esteve-Codina, Matthew Murtha, Alberto Bustillos, Lluís Millán-Ariño, Laura Pascual-Reguant, Andrea Izquierdo-Bouldstridge, Daniel García-Gomis, Sandra Peiró, Carles Bonet-Costa, Marc Dabad

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Nucleic Acids Research
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC

Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) of each H1 variant in breast cancer cells results in altered gene expression and proliferation differently in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254564650b4e8ea6b590918f881a2c79
http://hdl.handle.net/2445/122088

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Dynamics and dispensability of variant-specific histone H1 Lys-26/Ser-27 and Thr-165 post-translational modifications

Autor: Albert Jordan, Mónica Sancho, Regina Mayor, Alberto Bustillos, Alicia Roque, Sonia Vanina Forcales, Laura Torrente, Jordi Canes, Andrea Izquierdo-Bouldstridge, Jean-Michel Terme, Núria Sima, Pere Suau, Cristina Sampaio, Lluís Millán-Ariño, Isaura Font, Neus Luque

Publikováno v: FEBS LETTERS
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Digital.CSIC. Repositorio Institucional del CSIC

Jean-Michel Terme et al.
In mammals, the linker histone H1, involved in DNA packaging into chromatin, is represented by a family of variants. H1 tails undergo post-translational modifications (PTMs) that can be detected by mass spectrometry. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3bf214749dcdafb25a755c7c214edb
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2388

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Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2

Autor: Albert Jordan, Nuria Lopez-Bigas, Lluís Millán-Ariño, Neus Luque, Mónica Sancho, Andrea Izquierdo-Bouldstridge, Abul B. M. M. K. Islam, Jean-Michel Terme, Regina Mayor

Publikováno v: Europe PubMed Central
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
NUCLEIC ACIDS RESEARCH
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Recercat. Dipósit de la Recerca de Catalunya
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)

Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Despite being key structural components of chromatin, it is not known whether the different variants have specific roles in the regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0b3d13c8f2076a859844718ac60604
http://hdl.handle.net/10230/23347

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Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells

Autor: Lluís Millán-Ariño, Jose Luis Rosa, Albert Jordan, Mercè Obach, Laura Novellasdemunt, Anna Manzano, Àurea Navarro-Sabaté, Francesc Ventura, Ramon Bartrons

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P 2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is extensively involved in cell prolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd04625bc62de7f32db9f265b8e2598
https://pubmed.ncbi.nlm.nih.gov/22115192

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Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency

Autor: Lluís Millán-Ariño, Juan Carlos Izpisua Belmonte, Borja Sesé, Maria J. Barrero, Jean-Michel Terme, Albert Jordan, Regina Mayor

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

There are seven linker histone variants in human somatic cells (H1.0 to H1.5 and H1X), and their prevalence varies as a function of cell type and differentiation stage, suggesting that the different variants may have distinct roles. We have revisited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32663ca1f0db5d9fc098c8db87dac324
http://hdl.handle.net/10261/53102

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Mutational Analysis of Progesterone Receptor Functional Domains in Stable Cell Lines Delineates Sets of Genes Regulated by Different Mechanisms

Autor: Nora Spinedi, Belén Miñana, Ignacio Quiles, Albert Jordan, Alicia Subtil-Rodríguez, Miguel Beato, Cecilia Ballaré, Lluís Millán-Ariño

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Steroid hormone receptors act directly in the nucleus on the chromatin organization and transcriptional activity of several promoters. Furthermore, they have an indirect effect on cytoplasmic signal transduction pathways, including MAPK, impacting ul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce540a283d8aed8104abdece3a00bf1
https://europepmc.org/articles/PMC5419291/

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Progesterone induction of the 11β-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking

Autor: Ignacio Quiles, Cecilia Ballaré, Lluís Millán-Ariño, Alicia Subtil-Rodríguez, Miguel Beato, Albert Jordan

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Steroid hormone receptors regulate gene expression, interacting with target DNA sequences but also activating cytoplasmic signaling pathways. Using the human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) gene as a model, we have investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a914c4baeba9f18c82bd133326434c98
http://hdl.handle.net/10261/113957

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Akademický článek

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

Autor: Georges E. Janssens, Xin-Xuan Lin, Lluís Millan-Ariño, Alan Kavšek, Ilke Sen, Renée I. Seinstra, Nicholas Stroustrup, Ellen A.A. Nollen, Christian G. Riedel

Publikováno v: Cell Reports, Vol 27, Iss 2, Pp 467-480.e6 (2019)

Summary: Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of transcriptomics to

Externí odkaz: https://doaj.org/article/0f0d00ea6e6e44599aab71af29fa6f74

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