Výsledky vyhledávání - "Lluís Espinosa"

Akademický článek

Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression

Autor: Laura Marruecos, Joan Manils, Cristina Moreta, Diana Gómez, Ingrid Filgaira, Anna Serafin, Xavier Cañas, Lluís Espinosa, Concepció Soler

Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)

Abstract Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we found that single p5

Externí odkaz: https://doaj.org/article/36f5ec065d8846e28b72cd7234991a5f

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Akademický článek

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

Autor: Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel, LLuís Espinosa

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therap

Externí odkaz: https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f

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Akademický článek

Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis

Autor: Erika López-Arribillaga, Bing Yan, Teresa Lobo-Jarne, Yolanda Guillén, Silvia Menéndez, Montserrat Andreu, Anna Bigas, Mar Iglesias, Lluís Espinosa

Publikováno v: Cells, Vol 10, Iss 11, p 2928 (2021)

Background: Previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. Whether these cell populatio

Externí odkaz: https://doaj.org/article/a2b2abc47bf94a33859ea7afe20bbba6

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Akademický článek

NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer

Autor: Lluís Espinosa, Laura Marruecos

Publikováno v: Biomedicines, Vol 9, Iss 9, p 1278 (2021)

IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and func

Externí odkaz: https://doaj.org/article/69827e45c37147b49e2a4528960ac68f

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Akademický článek

Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Autor: Lidia García-Colmenero, Jéssica González, Juan Sandoval, Yolanda Guillén, Angel Diaz-Lagares, Evelyn Andrades, Arnau Iglesias, Lara Nonell, Ramon Maria Pujol, Anna Bigas, Lluís Espinosa, Fernando Gallardo

Publikováno v: Cells, Vol 9, Iss 12, p 2692 (2020)

Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is

Externí odkaz: https://doaj.org/article/d6329ff60193474e860ed2d3e0c2f144

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Akademický článek

Derivación de pacientes geriátricos subagudos a un hospital de atención intermedia como alternativa a la permanencia en un hospital general Intermediate hospital care for subacute elderly patients as an alternative to prolonged acute hospitalization

Autor: Marco Inzitari, Lluís Espinosa Serralta, María Carmen Pérez Bocanegra, Marta Roquè Fíguls, Josep Maria Argimón Pallàs, Joan Farré Calpe

Publikováno v: Gaceta Sanitaria, Vol 26, Iss 2, Pp 166-169 (2012)

Objetivos: Evaluar la derivación rápida de pacientes ancianos con enfermedades crónicas reagudizadas desde un hospital general a un hospital de atención intermedia. Métodos: Estudio de cohortes. Se valora el cumplimiento de estándares de calida

Externí odkaz: https://doaj.org/article/f81d8391e2b84190a4a66e721b827e41

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Akademický článek

Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer.

Autor: Julia Inglés-Esteve, Mònica Morales, Alba Dalmases, Ricard Garcia-Carbonell, Alba Jené-Sanz, Núria López-Bigas, Mar Iglesias, Cristina Ruiz-Herguido, Ana Rovira, Federico Rojo, Joan Albanell, Roger R Gomis, Anna Bigas, Lluís Espinosa

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e38347 (2012)

14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role in cancer relapse and met

Externí odkaz: https://doaj.org/article/944020d04a674d06a7a2745816d67924

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