Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lluís Ballell-Pages"'
Autor:
Henok Asfaw, Katja Laqua, Anna Maria Walkowska, Fraser Cunningham, Maria Santos Martinez-Martinez, Juan Carlos Cuevas-Zurita, Lluís Ballell-Pages, Peter Imming
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176088 (2017)
Wollamide B is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis (M. bovis) (IC50 of 3.1 μM). Aiming to define its structural activity relationship (SAR), optimizing potency and pharmacokinetic properti
Externí odkaz:
https://doaj.org/article/eea2060467404578b60d49862c64ef37
Autor:
David Barros, Robert J. Young, Roman Šink, Chun-wa Chung, Matej Živec, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Lourdes Encinas, Esther Pérez-Herrán, María Martínez-Hoyos, Stanislav Gobec, Julia Castro-Pichel, Stane Pajk, Alfonso Mendoza-Losana, Margarete Neu, Izidor Sosič, Máire A. Convery, Lluís Ballell-Pages
Publikováno v:
European Journal of Medicinal Chemistry. 112:252-257
Tetrahydropyran derivative 1 was discovered in a high-throughput screening campaign to find new inhibitors of mycobacterial InhA. Following initial in-vitro profiling, a structure-activity relationship study was initiated and a focused library of ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9785662700a98df8dac761fbd4f9570
https://doi.org/10.1016/j.ejmech.2016.02.008
https://doi.org/10.1016/j.ejmech.2016.02.008
Autor:
Laura Guijarro, Gemma L. Nixon, Laura M. Sanz, Iñigo Angulo-Barturen, Neil G. Berry, Stephen A. Ward, Paul M. O'Neill, Jaime de Mercado, Matthew McConville, Pablo Castañeda, Maria Santos Martinez-Martinez, Noemí Bahamontes-Rosa, Jorge Fernández, Michael J. Blackman, Micol Frigerio, Lluís Ballell-Pages, Giancarlo A. Biagini, María Belén Jiménez-Díaz, Cristina de Cozar, Benigno Crespo, Gina Washbourn, Angel Santos-Villarejo, Félix Calderón
Publikováno v:
Journal of Medicinal Chemistry. 58:6448-6455
Screening of the GSK corporate collection, some 1.9 million compounds, against Plasmodium falciparum (Pf), revealed almost 14000 active hits that are now known as the Tres Cantos Antimalarial Set (TCAMS). Followup work by Calderon et al. clustered an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd14503faddd37e9215c5172bcdcb39
https://doi.org/10.1021/acs.jmedchem.5b00434
https://doi.org/10.1021/acs.jmedchem.5b00434
Autor:
Mikko Vahermo, Lluís Ballell-Pages, Antti Siiskonen, Leena Keurulainen, Benigno Crespo-Fernández, Pablo Castaneda-Casado, Félix Calderón, Laura de las Heras-Dueña, Teppo O. Leino, Laura M. Sanz, Paula Kiuru, Laura Guijarro-López, Jari Yli-Kauhaluoma, Margarita Puente-Felipe, Sara Viera, Elena Sandoval-Izquierdo, Leticia Huertas-Valentin, M. Belen Jiménez-Díaz, Maria Santos Martinez-Martinez
Publikováno v:
Journal of Medicinal Chemistry. 58:4573-4580
Malaria continues to be a major global health problem, being particularly devastating in the African population under the age of five. Artemisinin-based combination therapies (ACTs) are the first-line treatment recommended by the WHO to treat Plasmod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e926a439328a48e237daaab2d7f04e4f
https://doi.org/10.1021/acs.jmedchem.5b00114
https://doi.org/10.1021/acs.jmedchem.5b00114
Autor:
Lluís Ballell-Pages, Katja Laqua, Henok Asfaw, Anna Maria Walkowska, Juan Carlos Cuevas-Zurita, Maria Santos Martinez-Martinez, Fraser Cunningham, Peter Imming
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176088 (2017)
PLoS ONE
PLoS ONE
Wollamide B is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis (M. bovis) (IC50 of 3.1 μM). Aiming to define its structural activity relationship (SAR), optimizing potency and pharmacokinetic properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50daf0f73f11938abc2a9505123ce30
http://europepmc.org/articles/PMC5397059?pdf=render
http://europepmc.org/articles/PMC5397059?pdf=render
Autor:
Adrien Breiman, Frédéric Altare, Karim Asehnoune, Lluís Ballell-Pages, Kevin Pethe, David Barros-Aguirre, Priscille Brodin, Mayra Silva-Miranda, Euloge Ekaza, Fanny Anne Ewann
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2015, 59 (1), pp.693. ⟨10.1128/AAC.03705-14⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (1), pp.693. ⟨10.1128/AAC.03705-14⟩
Antimicrobial Agents and Chemotherapy, 2015, 59 (1), pp.693. ⟨10.1128/AAC.03705-14⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (1), pp.693. ⟨10.1128/AAC.03705-14⟩
International audience; Tuberculosis remains a major health problem due to the emergence of drug-resistant strains of Mycobacterium tuberculosis. Some models have provided valuable information about drug resistance and efficacy; however, the translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7570e541fdae93094d4cf87d6142f847
https://doi.org/10.1128/AAC.03705-14
https://doi.org/10.1128/AAC.03705-14
Autor:
Roman Šink, Joaquin Rullas-Triconado, Lluís Ballell-Pages, Eva Maria Lopez-Roman, Robert J. Young, Lourdes Encinas, David Barros, Raquel Fernandez-Menendez, Samo Turk, Matej Živec, Stane Pajk, Izidor Sosič, Stanislav Gobec, Iñigo Angulo-Barturen, Daniel Alvarez-Gomez, Carolina Gonzales-Cortez
Publikováno v:
Journal of medicinal chemistry. 58(2)
Mycobacterial enoyl acyl carrier protein reductase (InhA) is a clinically validated target for the treatment of tuberculosis infections, a disease that still causes the death of at least a million people annually. A known class of potent, direct, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0a72912b45b843fc29f46f85708f4f
https://pubmed.ncbi.nlm.nih.gov/25517015
https://pubmed.ncbi.nlm.nih.gov/25517015
Autor:
Fraser Cunningham, Anita Ordas, Thomas Hankemeier, Susanne Jong-Raadsen, Malgorzata Wiweger, David Barros, Annemarie H. Meijer, Hans J. Jansen, Robert H. Bates, Herman P. Spaink, Ron P. Dirks, Rob J. Vreeken, Sabine Bos, Robert-Jan Raterink, Lluís Ballell-Pages
The translational value of zebrafish high-throughput screens can be improved when more knowledge is available on uptake characteristics of potential drugs. We investigated reference antibiotics and 15 preclinical compounds in a translational zebrafis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494049193b4fbe75d8d3e53df7ab46fc
https://hdl.handle.net/1887/3197326
https://hdl.handle.net/1887/3197326
Autor:
Leena Keurulainen, Mikko Vahermo, Margarita Puente-Felipe, Elena Sandoval-Izquierdo, Benigno Crespo-Fernández, Laura Guijarro-López, Leticia Huertas-Valentín, Laura de las Heras-Dueña, Teppo O. Leino, Antti Siiskonen, Lluís Ballell-Pages, Laura M. Sanz, Pablo Castañeda-Casado, M. Belén Jiménez-Díaz, María S. Martínez-Martínez, Sara Viera, Paula Kiuru, Félix Calderón, Jari Yli-Kauhaluoma
Publikováno v:
Journal of Medicinal Chemistry; Jun2015, Vol. 58 Issue 11, p4573-4580, 8p