Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lluís, Raich"'
Autor:
Sybrin P. Schröder, Casper de Boer, Nicholas G. S. McGregor, Rhianna J. Rowland, Olga Moroz, Elena Blagova, Jos Reijngoud, Mark Arentshorst, David Osborn, Marc D. Morant, Eric Abbate, Mary A. Stringer, Kristian B. R. M. Krogh, Lluís Raich, Carme Rovira, Jean-Guy Berrin, Gilles P. van Wezel, Arthur F. J. Ram, Bogdan I. Florea, Gijsbert A. van der Marel, Jeroen D. C. Codée, Keith S. Wilson, Liang Wu, Gideon J. Davies, Herman S. Overkleeft
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 1067-1078 (2019)
Externí odkaz:
https://doaj.org/article/f864bdc8d62e4812a1bdf17abbce08b0
Autor:
Nurit P Azouz, Andrea Klingler, Victoria Callahan, Ivan Akhrymuk, Katarina Elez, Lluís Raich, Brandon Henry, Justin Benoit, Stefanie Benoit, Frank Noé, Kylene Kehn-Hall, Marc Rothenberg
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 1 (2021)
Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine prote
Externí odkaz:
https://doaj.org/article/02d7c92c7edd4daab794fc904a01876d
Autor:
Jitka Dadová, Kuan-Jung Wu, Patrick G. Isenegger, James C. Errey, Gonçalo J. L. Bernardes, Justin M. Chalker, Lluís Raich, Carme Rovira, Benjamin G. Davis
Publikováno v:
ACS Central Science, Vol 3, Iss 11, Pp 1168-1173 (2017)
Externí odkaz:
https://doaj.org/article/e254706682fc4e598fa1f6f9680b656b
Autor:
Marta Artola, Liang Wu, Maria J. Ferraz, Chi-Lin Kuo, Lluís Raich, Imogen Z. Breen, Wendy A. Offen, Jeroen D. C. Codée, Gijsbert A. van der Marel, Carme Rovira, Johannes M. F. G. Aerts, Gideon J. Davies, Herman S. Overkleeft
Publikováno v:
ACS Central Science, Vol 3, Iss 7, Pp 784-793 (2017)
Externí odkaz:
https://doaj.org/article/ed80748b307b4500a299decac625948f
Autor:
Johannes Schimunek, Philipp Seidl, Katarina Elez, Tim Hempel, Tuan Le, Frank Noé, Simon Olsson, Lluís Raich, Robin Winter, Hatice Gokcan, Filipp Gusev, Evgeny M. Gutkin, Olexandr Isayev, Maria G. Kurnikova, Chamali H. Narangoda, Roman Zubatyuk, Ivan P. Bosko, Konstantin V. Furs, Anna D. Karpenko, Yury V. Kornoushenko, Mikita Shuldau, Artsemi Yushkevich, Mohammed B. Benabderrahmane, Patrick Bousquet-Melou, Ronan Bureau, Beatrice Charton, Bertrand C. Cirou, Gérard Gil, William J. Allen, Suman Sirimulla, Stanley Watowich, Nick A. Antonopoulos, Nikolaos E. Epitropakis, Agamemnon K. Krasoulis, Vassilis P. Pitsikalis, Stavros T. Theodorakis, Igor Kozlovskii, Anton Maliutin, Alexander Medvedev, Petr Popov, Mark Zaretckii, Hamid Eghbal-zadeh, Christina Halmich, Sepp Hochreiter, Andreas Mayr, Peter Ruch, Michael Widrich, Francois Berenger, Ashutosh Kumar, Yoshihiro Yamanishi, Kam Y.J. Zhang, Emmanuel Bengio, Yoshua Bengio, Moksh J. Jain, Maksym Korablyov, Cheng-Hao Liu, Gilles Marcou, Enrico Glaab, Kelly Barnsley, Suhasini M. Iyengar, Mary Jo Ondrechen, V. Joachim Haupt, Florian Kaiser, Michael Schroeder, Luisa Pugliese, Simone Albani, Christina Athanasiou, Andrea Beccari, Paolo Carloni, Giulia D'Arrigo, Eleonora Gianquinto, Jonas Goßen, Anton Hanke, Benjamin P. Joseph, Daria B. Kokh, Sandra Kovachka, Candida Manelfi, Goutam Mukherjee, Abraham Muñiz-Chicharro, Francesco Musiani, Ariane Nunes-Alves, Giulia Paiardi, Giulia Rossetti, S. Kashif Sadiq, Francesca Spyrakis, Carmine Talarico, Alexandros Tsengenes, Rebecca C. Wade, Conner Copeland, Jeremiah Gaiser, Daniel R. Olson, Amitava Roy, Vishwesh Venkatraman, Travis J. Wheeler, Haribabu Arthanari, Klara Blaschitz, Marco Cespugli, Vedat Durmaz, Konstantin Fackeldey, Patrick D. Fischer, Christoph Gorgulla, Christian Gruber, Karl Gruber, Michael Hetmann, Jamie E. Kinney, Krishna M. Padmanabha Das, Shreya Pandita, Amit Singh, Georg Steinkellner, Guilhem Tesseyre, Gerhard Wagner, Zi-Fu Wang, Ryan J. Yust, Dmitry S. Druzhilovskiy, Dmitry A. Filimonov, Pavel V. Pogodin, Vladimir Poroikov, Anastassia V. Rudik, Leonid A. Stolbov, Alexander V. Veselovsky, Maria De Rosa, Giada De Simone, Maria R. Gulotta, Jessica Lombino, Nedra Mekni, Ugo Perricone, Arturo Casini, Amanda Embree, D. Benjamin Gordon, David Lei, Katelin Pratt, Christopher A. Voigt, Kuang-Yu Chen, Yves Jacob, Tim Krischuns, Pierre Lafaye, Agnès Zettor, M. Luis Rodríguez, Kris M. White, Daren Fearon, Frank Von Delft, Martin A. Walsh, Dragos Horvath, Charles L. Brooks III, Babak Falsafi, Bryan Ford, Adolfo García-Sastre, Sang Yup Lee, Nadia Naffakh, Alexandre Varnek, Günter Klambauer, Thomas M. Hermans
The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28010b1a0350f378ef0dcc633e87f6e1
https://doi.org/10.26434/chemrxiv-2023-1d5w8
https://doi.org/10.26434/chemrxiv-2023-1d5w8
Autor:
Yi Jin, Marija Petricevic, Alan John, Lluís Raich, Huw Jenkins, Leticia Portela De Souza, Fiona Cuskin, Harry J. Gilbert, Carme Rovira, Ethan D. Goddard-Borger, Spencer J. Williams, Gideon J. Davies
Publikováno v:
ACS Central Science, Vol 2, Iss 12, Pp 896-903 (2016)
Externí odkaz:
https://doaj.org/article/346ed882cf844ea0af975f41b16ef100
Autor:
Valentina Borlandelli, Zachary Armstrong, Alba Nin‐Hill, Jeroen D. C. Codée, Lluís Raich, Marta Artola, Carme Rovira, Gideon J. Davies, Herman S. Overkleeft
Publikováno v:
ChemMedChem
Degradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM-remodeling enzyme with β-D-endo-glucuronidase activity overexpressed in seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68f045417249dcdce54410295f9e612
https://doi.org/10.1002/cmdc.202200580
https://doi.org/10.1002/cmdc.202200580
Autor:
Kylene Kehn-Hall, Justin L. Benoit, Andrea M. Klingler, Marc E. Rothenberg, Katarina Elez, Lluís Raich, Ivan V. Akhrymuk, Brandon Michael Henry, Nurit P. Azouz, Victoria Callahan, Frank Noé, Stefanie W. Benoit
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
Pathogens and Immunity
article-version (status) pre
article-version (number) 2
Pathogens and Immunity
Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease 2 (TMPRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0922b0d6f0ac17e7632873c25f446f99
https://doi.org/10.20411/pai.v6i1.408
https://doi.org/10.20411/pai.v6i1.408
Autor:
Claude Solleux, Valentina Kalichuk, David Teze, Joan Coines, Corinne André-Miral, Lluís Raich, Carme Rovira, Birte Svensson, Charles Tellier
Publikováno v:
Teze, D, Coines, J, Raich, L, Kalichuk, V, Solleux, C, Tellier, C, André-Miral, C, Svensson, B & Rovira, C 2020, ' A Single Point Mutation Converts GH84 O-GlcNAc Hydrolases into Phosphorylases: Experimental and Theoretical Evidence ', Journal of the American Chemical Society, vol. 142, no. 5, pp. 2120-2124 . https://doi.org/10.1021/jacs.9b09655
Glycoside hydrolases and phosphorylases are two major classes of enzymes responsible for the cleavage of glycosidic bonds. Here we show that two GH84 O-GlcNAcase enzymes can be converted to efficient phosphorylases by a single point mutation. Notewor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faac0b50615939e885bae04a84487fbf
https://doi.org/10.1021/jacs.9b09655
https://doi.org/10.1021/jacs.9b09655
Autor:
Frank Noé, Heike Hofmann-Winkler, Joan C. Smith, Katsura Yamatsuta, Ole S. Søgaard, Lluís Raich, Hirotaka Mizuno, Simon Olsson, Lambert K. Sørensen, Olga Danov, Takashi Yamazoe, Stephan Ludwig, Jason M. Sheltzer, Jørgen B. Hasselstrøm, Michael Winkler, Armin Braun, Danny Jonigk, Tim Hempel, Stefan Pöhlmann, Markus Hoffmann, Mads Kjolby, Nadine Krüger, Prerna Arora
Publikováno v:
EBioMedicine
bioRxiv
article-version (status) pre
article-version (number) 1
Hoffmann, M, Hofmann-Winkler, H, Smith, J C, Krüger, N, Arora, P, Sørensen, L K, Søgaard, O S, Hasselstrøm, J B, Winkler, M, Hempel, T, Raich, L, Olsson, S, Danov, O, Jonigk, D, Yamazoe, T, Yamatsuta, K, Mizuno, H, Ludwig, S, Noé, F, Kjolby, M, Braun, A, Sheltzer, J M & Pöhlmann, S 2021, ' Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity ', EBioMedicine, vol. 65, 103255 . https://doi.org/10.1016/j.ebiom.2021.103255
bioRxiv
article-version (status) pre
article-version (number) 1
Hoffmann, M, Hofmann-Winkler, H, Smith, J C, Krüger, N, Arora, P, Sørensen, L K, Søgaard, O S, Hasselstrøm, J B, Winkler, M, Hempel, T, Raich, L, Olsson, S, Danov, O, Jonigk, D, Yamazoe, T, Yamatsuta, K, Mizuno, H, Ludwig, S, Noé, F, Kjolby, M, Braun, A, Sheltzer, J M & Pöhlmann, S 2021, ' Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity ', EBioMedicine, vol. 65, 103255 . https://doi.org/10.1016/j.ebiom.2021.103255
Background Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c912b34a71338cc57ee5fcf28cf375e
http://europepmc.org/articles/PMC7930809
http://europepmc.org/articles/PMC7930809