Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Lloyd Tan"'
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Liquid biopsy tracking during sequential chemo-radiotherapy identifies distinct prognostic phenotypes in nasopharyngeal carcinoma
Autor: Kuan Rui Lloyd Tan, Zhen-Yu Qi, Haitao Wang, Li Lin, Rui-Qi Liu, Jia-Wei Lv, Yue Chen, Ying Sun, Xiao-Dan Huang, Melvin L.K. Chua, Jun Ma, Lu-Lu Zhang, Yu Pei Chen, Si-Si Xu, Guan-Qun Zhou, Fo-Ping Chen
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Liquid biopsies have the utility for detecting minimal residual disease in several cancer types. Here, we investigate if liquid biopsy tracking on-treatment informs on tumour phenotypes by longitudinally quantifying circulating Epstein-barr virus (EB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1633164adbc9537d4b9907c54fc5a763
https://doaj.org/article/9928a95fca794df79074104762ef818c
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2
Akademický článek
A novel quinoline with airway relaxant effects and anti-inflammatory properties
Autor: Jesper Bergwik, Jielu Liu, Médea Padra, Ravi K. V. Bhongir, Lloyd Tanner, Yujiao Xiang, Mia Lundblad, Arne Egesten, Mikael Adner
Publikováno v: Respiratory Research, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad ran
Externí odkaz: https://doaj.org/article/dd0575e4dc414befa4090bcfd48ccd10
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3
NIMG-32. THE PREDICTIVE CAPACITY OF PRE-OPERATIVE IMAGING ANALYSIS IN DIFFUSE GLIOMA: A COMPARISON OF CONNECTOMICS, RADIOMICS, AND CLINICAL PREDICTIVE MODELS
Autor: Lloyd Tan, Mei Chin Lim, John S. Kuo, Clement Yong, Rebecca Harrison, Bryce W.Q. Tan, Hong Qi Tan, Shelli R. Kesler
Publikováno v: Neuro Oncol
BACKGROUND Radiomics and connectome analysis are distinct and non-invasive methods of deriving biologic information from MRI. Radiomics analyzes features intrinsic to the tumor, and connectomics incorporates data regarding the tumor and surrounding n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5814f132b80105ea636a7d1f6ab2c2e8
https://europepmc.org/articles/PMC7651490/
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4
Development of a Clinicomolecular Risk Stratification System for Non-Metastatic Nasopharyngeal Carcinoma Using Epstein-Barr Virus DNA and TNM Stage in 9,160 Endemic Cases from Southern China
Autor: Zi-Qi Zheng, Xiao-Jun He, Jun Ma, Xin-Yu He, Chen-Fei Wu, Ying Guo, Bao Ting Zhu, Kuan Rui Lloyd Tan, Jia-Wei Lv, Guan-Qun Zhou, Lu-Lu Zhang, Fo-Ping Chen, Li Lin, Melvin L.K. Chua, Jia Kou, Xiao-Dan Huang, Ying-Shan Luo, Ying Sun
Publikováno v: SSRN Electronic Journal.
Background: To construct a clinicomolecular index integrating circulating Epstein-barr virus DNA (cfEBV DNA) with T- and N- categories for prognostication in nasopharyngeal carcinoma (NPC). Methods: We utilised medical records of 9,160 biopsy-proven,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c63220d90363c22d5ad15eee728fcd2
https://doi.org/10.2139/ssrn.3244952
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5
Longitudinal circulating Epstein–Barr virus DNA response to induction chemotherapy and chemo-radiotherapy to identify biological phenotypes in EBV-associated nasopharynx of head and neck cancer
Autor: Yu Pei Chen, Kuan Rui Lloyd Tan, Ying Sun, Guan-Qun Zhou, Jun Ma, Jia-Wei Lv, Melvin L.K. Chua
Publikováno v: Journal of Clinical Oncology. 37:6021-6021
6021 Background: Liquid biopsies have the utility for detecting minimal residual disease in several cancers, but its clinical utility for real-time treatment adaptation remains limited. We adopted Epstein-barr virus (EBV)-associated nasopharyngeal ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3c1a9fa499d68fd6874c7244eaa696d
https://doi.org/10.1200/jco.2019.37.15_suppl.6021
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6
Development of a clinicomolecular risk stratification system for nonmetastatic nasopharyngeal carcinoma using Epstein–Barr virus DNA and TNM stage: A 'Big data' analysis of 9,160 endemic cases
Autor: Kuan Rui Lloyd Tan, Sze Huey Tan, Fo-Ping Chen, Ying-Shan Luo, Guan-Qun Zhou, Jun Ma, Li Lin, Yu Zheng, Melvin L.K. Chua, Ying Guo, Ying Sun
Publikováno v: Journal of Clinical Oncology. 37:6043-6043
6043 Background: To construct a clinicomolecular index integrating circulating Epstein-barr virus (cfEBV) DNA with T- and N- categories for better prognostication in nasopharyngeal carcinoma (NPC). Methods: Clinical and treatment records of 9,160 bio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af0fcc1e7b572e9bf1ea7b7b7c6213d0
https://doi.org/10.1200/jco.2019.37.15_suppl.6043
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7
Akademický článek
Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury
Autor: Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), re
Externí odkaz: https://doaj.org/article/340dac68eeb842cba993be2b6019607c
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8
Akademický článek
Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1
Autor: Yaoyao Xue, Lang Pan, Spiros Vlahopoulos, Ke Wang, Xu Zheng, Zsolt Radak, Attila Bacsi, Lloyd Tanner, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. Activated transcription factors in conjunction with chromatin remodelers induce epigeneti
Externí odkaz: https://doaj.org/article/672e0898900943f687352329b70e5da3
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9
Akademický článek
Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions
Autor: Xu Zheng, Ke Wang, Lang Pan, Wenjing Hao, Yaoyao Xue, Attila Bacsi, Spiros A. Vlahopoulos, Zsolt Radak, Tapas K. Hazra, Allan R. Brasier, Lloyd Tanner, Xueqing Ba, Istvan Boldogh
Publikováno v: Journal of Innate Immunity, Pp 1-22 (2022)
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes a
Externí odkaz: https://doaj.org/article/ba22675d361a4cf585f761a801225ab6
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10
Akademický článek
Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection
Autor: Lloyd Tanner, Jesper Bergwik, Ravi K. V. Bhongir, Manoj Puthia, Pernilla Lång, Mohamad N. Ali, Charlotte Welinder, Patrik Önnerfjord, Jonas S. Erjefält, Lena Palmberg, Göran Andersson, Arne Egesten
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
IntroductionDuring airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contri
Externí odkaz: https://doaj.org/article/2ee8d6efa52445b69b6dfca1ea9deb16
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