Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lloyd S. Gray"'
Autor:
Jill K. Slack-Davis, Jaroslaw Dziegielewski, Lloyd S. Gray, Wesley Z. Yang, Eli V. Casarez, Barbara Dziegielewska
Supplementary Figure 1: Relative T-type Ca2+ channel gene expression; Supplementary Figure 2: Down regulation of T-type Ca2+ channel gene expression decreases survivin protein level; Supplementary Figure 3: Effects of Mibefradil on AKT activity and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08cf7baeb238d29c49c58e0dcfcec02
https://doi.org/10.1158/1535-7163.22503112.v1
https://doi.org/10.1158/1535-7163.22503112.v1
Autor:
Roger Abounader, Lloyd S. Gray, Emanuel F. Petricoin, Stephen D. Turner, David Schiff, Eli E. Bar, Jeongwu Lee, Christopher Papanicolas, Sarah Hatef, Alexander F. Koeppel, Isela Gallagher, Julia Wulfkuhle, Mary Pahuski, Baomin Wang, Fang Yuan, Nichola Cruickshanks, Ying Zhang
Supplementary methods containing descriptions of PCR primer sequences, Reverse Phase Protein Arrays, RNA-seq, and Rescue Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b04dd685fe00c0cdfbe7215d5b464da
https://doi.org/10.1158/0008-5472.22413443.v1
https://doi.org/10.1158/0008-5472.22413443.v1
Autor:
Roger Abounader, Lloyd S. Gray, Emanuel F. Petricoin, Stephen D. Turner, David Schiff, Eli E. Bar, Jeongwu Lee, Christopher Papanicolas, Sarah Hatef, Alexander F. Koeppel, Isela Gallagher, Julia Wulfkuhle, Mary Pahuski, Baomin Wang, Fang Yuan, Nichola Cruickshanks, Ying Zhang
Supplementary figures: 1): molecular structure of mibefradil, 2) Mibefradil effects on HIFs, 3) effects of sh-RNA inhibition of Cav3.2 in GSCs, 4) Schematic summary of the findings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abf13a9118e0ab59d5144def36f51f2
https://doi.org/10.1158/0008-5472.22413440
https://doi.org/10.1158/0008-5472.22413440
Autor:
Roger Abounader, Lloyd S. Gray, Emanuel F. Petricoin, Stephen D. Turner, David Schiff, Eli E. Bar, Jeongwu Lee, Christopher Papanicolas, Sarah Hatef, Alexander F. Koeppel, Isela Gallagher, Julia Wulfkuhle, Mary Pahuski, Baomin Wang, Fang Yuan, Nichola Cruickshanks, Ying Zhang
Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2. This calcium cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55cd1f54f8281700ec886b6615dbf2b4
https://doi.org/10.1158/0008-5472.c.6508712.v1
https://doi.org/10.1158/0008-5472.c.6508712.v1
Autor:
Isela Gallagher, Julia Wulfkuhle, Christopher Papanicolas, Roger Abounader, David Schiff, Mary Pahuski, Fang Yuan, Ying Zhang, Jeongwu Lee, Baomin Wang, Eli E. Bar, Alexander F. Koeppel, Sarah Hatef, Stephen D. Turner, Emanuel F. Petricoin, Lloyd S. Gray, Nichola Cruickshanks
Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2. This calcium cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283ace7523fb4db5247b72162683f36d
https://europepmc.org/articles/PMC5505315/
https://europepmc.org/articles/PMC5505315/
Publikováno v:
Expert Review of Anticancer Therapy. 13:589-595
Ca(2+) influx at critical points in the cell cycle is required for proliferation. This requirement is so ubiquitous that its occurrence is often treated as background noise. Yet without it, cells stop dividing, suggesting an obvious and potentially e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751ce13185d825ce534848075f5cdd00
https://doi.org/10.1586/era.13.34
https://doi.org/10.1586/era.13.34
Autor:
Ewa Augustin, Lloyd S. Gray, Nicholas C.K. Valerie, Jaroslaw Dziegielewski, David L. Brautigan, Barbara Dziegielewska, James M. Larner, Amol S. Hosing
Publikováno v:
Biochemical Pharmacology. 85:888-897
Glioblastoma multiforme (GBM) are brain tumors that are exceptionally resistant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79a1bd209c86a3900259d6cf5864e40
https://doi.org/10.1016/j.bcp.2012.12.017
https://doi.org/10.1016/j.bcp.2012.12.017
Publikováno v:
Journal of Cancer Therapy. :32-40
The purpose of this study is to demonstrate MCF-7 cells’ dependence on calcium for growth and to exploit that dependence to improve chemotherapy efficacy. Fura-2 fluorescence imaging shows that MCF-7 cells maintain a higher basal intracellular calc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c6907bed9e2a4ebbb8f73dbabd2778d
https://doi.org/10.4236/jct.2013.47a006
https://doi.org/10.4236/jct.2013.47a006
Publikováno v:
Assay and drug development technologies. 13(10)
The expanding "valley of death" in drug development is leaving potentially life-saving new chemical entities and molecular targets fallow. This situation is forcing early-stage companies to think creatively about moving their technologies forward, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545e176518364e3217f6f1e6d38deced
https://pubmed.ncbi.nlm.nih.gov/26690767
https://pubmed.ncbi.nlm.nih.gov/26690767
Autor:
Eli V. Casarez, Barbara Dziegielewska, Jaroslaw Dziegielewski, Lloyd S. Gray, Wesley Z. Yang, Jill K. Slack-Davis
Publikováno v:
Molecular cancer therapeutics. 15(3)
Ovarian cancer is the deadliest gynecologic cancer, due in large part to the diagnosis of advanced stage disease, the development of platinum resistance, and inadequate treatment alternatives. Recent studies by our group and others have shown that T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc036e66ec91bdf152311aaac68f63e5
https://pubmed.ncbi.nlm.nih.gov/26832797
https://pubmed.ncbi.nlm.nih.gov/26832797