Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lloyd J. Simons"'
Autor:
Allan Scott Wagman, Sara Lopez, Lloyd J. Simons, James B. Aggen, Ryan Cirz, Glenn McEnroe, Christina R. Harris, Adam Aaron Goldblum, Heinz E. Moser, Ricky D. Gaston, Michael Melnick, Toni-Jo Poel, M. A. Gómez, George Miller, Martin S. Linsell, Thomas R. Belliotti
Publikováno v:
ChemMedChem. 12:1687-1692
Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a seven-membered ring between the pyrrolidine substituents and the C8 position on the FQ core scaffo
Autor:
Ake P. Elhammer, Peter Wuts, Lloyd J Simons, Brian P. Metzger, Rachel C Sterling, Jerry L. Slightom
Publikováno v:
ACS Medicinal Chemistry Letters. 6:645-649
The natural product aureobasidin A (AbA) is a potent, well-tolerated antifungal agent with robust efficacy in animals. Although native AbA is active against a number of fungi, it has little activity against Aspergillus fumigatus, an important human p
Autor:
Glenn McEnroe, Sara Lopez, Lloyd J. Simons, Thomas R. Belliotti, Ryan Cirz, Christina R. Harris, George H. Miller, Toni-Jo Poel, Heinz E. Moser, Allan Scott Wagman, Adam Aaron Goldblum, Ricky D. Gaston, M. A. Gómez, James B. Aggen, Martin S. Linsell, Michael Melnick
Publikováno v:
ChemMedChem. 12:1656-1656
Publikováno v:
Tetrahedron: Asymmetry. 14:743-747
Efficient, formal syntheses of aphanorphine and eptazocine are reported that involve epoxide cyclizations. The necessary chiral epoxides were prepared following treatment of diols prepared by Sharpless asymmetric osmylations of an alkene. The cycliza
Autor:
Stephen K. Taylor, Lloyd J. Simons, Noelle K. Wood, Mary A. Wemple, James R. Vyvyan, Dawn DeYoung
Publikováno v:
Synthetic Communications. 28:1691-1701
The nucleophilic opening of epoxides by nitrile enolates using an efficient, convenient protocol is described. The diastereoselectivity of this reaction was explored and found to give syn:anti ratios ranging from 1.1:1.0 to 4.8:1.0. ‡ Camille and H
Autor:
Aaron T. Gerds, Min Ken Liao, Keri M. Law, Stephen K. Taylor, Thomas Goyne, Dale L. Kling, Lloyd J. Simons, Jennifer S. Yamaoka, James R. Vyvyan, Matthew G. Pridgeon, Carrie R. Arnold, Nathan D. Ide
Publikováno v:
Tetrahedron: Asymmetry. 15:3819-3821
An enzyme was expressed in Escherichia coli from a cloned amidase gene. When characterized, it was more enantioselective than commercial amidases. Three pheromones were made using this biotransformation chemistry.
Publikováno v:
ChemInform. 28
Autor:
Noelle K. Wood, Dawn DeYoung, Lloyd J. Simons, James R. Vyvyan, Stephen K. Taylor, Mary A. Wemple
Publikováno v:
ChemInform. 29
The nucleophilic opening of epoxides by nitrile enolates using an efficient, convenient protocol is described. The diastereoselectivity of this reaction was explored and found to give syn:anti ratios ranging from 1.1:1.0 to 4.8:1.0. ‡ Camille and H
Publikováno v:
The Journal of Organic Chemistry. 61:9084-9085