Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lloyd Frick"'
Autor:
Lloyd Frick, John C. Drach, Joseph H. Chan, Dean W. Selleseth, Stanley D. Chamberlain, George W. Koszalka, Ernest H. Dark, Robert J. Harvey, Karen K. Biron, Leroy B. Townsend, R E Dornsife, Michelle G. Davis
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:101-123
A series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94) were synthesized and evaluated for activity against human cytomegalovirus (HCMV) and for cytotoxicity. The 2-subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e3c56352778834b481dfb60df98d2e
https://doi.org/10.1080/15257770008032999
https://doi.org/10.1080/15257770008032999
Publikováno v:
American Journal of Infection Control. 43:S43-S44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28da4f881af380f8612ed4c76d85b3f9
https://doi.org/10.1016/j.ajic.2015.04.110
https://doi.org/10.1016/j.ajic.2015.04.110
Publikováno v:
Pharmaceutical Science & Technology Today. 1:12-18
Cassette dosing, combining many test chemicals into one dose solution, is an attractive method for increasing the throughput of in vivo pharmacokinetic experiments. This dosing technique depends on the sensitivity and selectivity of modern analytical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65390ae82929b015465de42407b02847
https://doi.org/10.1016/s1461-5347(98)00010-8
https://doi.org/10.1016/s1461-5347(98)00010-8
Autor:
Barry G. Shearer, Edward P. Garvey, Jeffrey Alan Oplinger, Lloyd Frick, Furfine Eric Steven, Shuliang Lee
Publikováno v:
Journal of Medicinal Chemistry. 40:1901-1905
S-Ethyl N-phenylisothiourea (4) has been found to be a potent inhibitor of both the human constitutive and inducible isoforms of nitric oxide synthase. A series of substituted N-phenylisothiourea analogues was synthesized to investigate the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cf6a6ad4de49c3148e1079d20f5be0
https://doi.org/10.1021/jm960785c
https://doi.org/10.1021/jm960785c
Publikováno v:
American Journal of Infection Control. 44:S87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64ed7211653c23fe4b7ae67a30ea5fd4
https://doi.org/10.1016/j.ajic.2016.04.099
https://doi.org/10.1016/j.ajic.2016.04.099
Autor:
T. J. Holmes, Marty St. Clair, George W. Koszalka, Thomas A. Krenitsky, C. L. Burns, Devron Averett, M. L. English, Lloyd Frick, Thomas Spector
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4cabc38fd5f0e0d8539257ead9a49f1
https://doi.org/10.1002/chin.199408290
https://doi.org/10.1002/chin.199408290
Autor:
Donald J. Nelson, P A Furman, R E Dornsife, Lloyd Frick, D C Liotta, M T Paff, J A Wurster, James A. Fyfe, L J Wilson, Michelle G. Davis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:2686-2692
The anti-hepatitis B (anti-HBV) activities of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (2'-deoxy-3'-thia-5-fluorocytosine [FTC]) were studied by using an HBV-transfected cell line (HepG2 derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db0561b7b0df3d76dc1a55faa69608a
https://doi.org/10.1128/aac.36.12.2686
https://doi.org/10.1128/aac.36.12.2686
Autor:
Sab A. Randhawa, Lloyd Frick, Vicente Samano, David Lee Musso, John A. Ray, Wendy Y. Mills, Stanley D. Chamberlain, Terrence L. Smalley
Publikováno v:
ChemInform. 39
A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f1f5e5cf969cfe54be2289a5088b24
https://doi.org/10.1002/chin.200809154
https://doi.org/10.1002/chin.200809154
Autor:
David Lee Musso, Wendy Y. Mills, Vicente Samano, John A. Ray, Sab A. Randhawa, Lloyd Frick, Stanley D. Chamberlain, Terrence L. Smalley
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e36088860c4b8bee2b98353a1f116cc
https://pubmed.ncbi.nlm.nih.gov/17870531
https://pubmed.ncbi.nlm.nih.gov/17870531
Autor:
Renae M. Crosby, David W. Rusnak, Jeff T. Hutchins, Alan Payne, Scott Depee, Peiyuan Lin, Stanley D. Chamberlain, Ian James, Jennifer H. Johnson, Marilyn Jansen, Min-Hwa Jasmine Lin, Lloyd Frick, Eva Shaw, K. Fuller, James G. Conway, Timothy J. Chambers, Janet H. Parham, Frederick C. Kull, Sarva M. Tadepalli, Bart J. Votta, Barry R. Keith, Brad McDonald
Colony-stimulating-factor-1 (CSF-1) signaling through cFMS receptor kinase is increased in several diseases. To help investigate the role of cFMS kinase in disease, we identified GW2580, an orally bioavailable inhibitor of cFMS kinase. GW2580 complet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e29eabb628cf54b5f8efe6bf8539a2
https://europepmc.org/articles/PMC1276040/
https://europepmc.org/articles/PMC1276040/
