Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lloyd D. W. King"'
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Jordan R. Barrett, Sarah E. Silk, Catherine G. Mkindi, Karolina M. Kwiatkowska, Mimi M. Hou, Amelia M. Lias, Wilmina F. Kalinga, Ivanny M. Mtaka, Kirsty McHugh, Martino Bardelli, Hannah Davies, Lloyd D. W. King, Nick J. Edwards, Virander S. Chauhan, Paushali Mukherjee, Stella Rwezaula, Chetan E. Chitnis, Ally I. Olotu, Angela M. Minassian, Simon J. Draper, Carolyn M. Nielsen
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
We have previously reported primary endpoints of a clinical trial testing two vaccine platforms for the delivery of Plasmodium vivax malaria DBPRII: viral vectors (ChAd63, MVA), and protein/adjuvant (PvDBPII with 50µg Matrix-M™ adjuvant). Delayed
Externí odkaz:
https://doaj.org/article/1d778520743644f7bdf485e7bb8929be
Autor:
Julie Healer, Jennifer K. Thompson, Karen L. Mackwell, Cecille D. Browne, Benjamin A. Seager, Anna Ngo, Kym N. Lowes, Sarah E. Silk, David Pulido, Lloyd D. W. King, Jayne M. Christen, Amy R. Noe, Vinayaka Kotraiah, Paul J. Masendycz, Rajkannan Rajagopalan, Leanne Lucas, Marianne M. Stanford, Lorraine Soisson, Carter Diggs, Robin Miller, Susan Youll, Kaye Wycherley, Simon J. Draper, Alan F. Cowman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundRH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds to Ripr and CyRPA at the apical end of the invasive merozoite form, and
Externí odkaz:
https://doaj.org/article/84dce22671ea4ea78f35e3a24b9607b4
Autor:
Robert J. Ragotte, David Pulido, Francesca R. Donnellan, Michelle L. Hill, Giacomo Gorini, Hannah Davies, Juliane Brun, Kirsty McHugh, Lloyd D. W. King, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Nicole Zitzmann, Simon J. Draper
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Reducing the mortality and morbidity associated with COVID-19 remains a global health priority. Vaccines have proven highly effective at preventing infection and hospitalization, but efforts must continue to improve treatment options for those who st
Externí odkaz:
https://doaj.org/article/614e579dc1434819ab00e4dbdcf745a2
Autor:
Anna E. Schager, C. Coral Dominguez-Medina, Francesca Necchi, Francesca Micoli, Yun Shan Goh, Margaret Goodall, Adriana Flores-Langarica, Saeeda Bobat, Charlotte N. L. Cook, Melissa Arcuri, Arianna Marini, Lloyd D. W. King, Faye C. Morris, Graham Anderson, Kai-Michael Toellner, Ian R. Henderson, Constantino López-Macías, Calman A. MacLennan, Adam F. Cunningham
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease. Immunization with naturally shed outer membrane vesicles from Gram
Externí odkaz:
https://doaj.org/article/ae8cd71bd8374ad680c8e90aa28c510e
Autor:
Mimi M. Hou, Jordan R. Barrett, Yrene Themistocleous, Thomas A. Rawlinson, Ababacar Diouf, Francisco J. Martinez, Carolyn M. Nielsen, Amelia M. Lias, Lloyd D. W. King, Nick J. Edwards, Nicola M. Greenwood, Lucy Kingham, Ian D. Poulton, Baktash Khozoee, Cyndi Goh, Dylan J. Mac Lochlainn, Jo Salkeld, Micheline Guilotte-Blisnick, Christèle Huon, Franziska Mohring, Jenny M. Reimer, Virander S. Chauhan, Paushali Mukherjee, Sumi Biswas, Iona J. Taylor, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Carole A. Long, Robert W. Moon, Kazutoyo Miura, Sarah E. Silk, Chetan E. Chitnis, Angela M. Minassian, Simon J. Draper
BackgroundThere are no licensed vaccines against Plasmodium vivax, the most common cause of malaria outside of Africa.MethodsWe conducted two Phase I/IIa clinical trials to assess the safety, immunogenicity and efficacy of two vaccines targeting regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364b22e40ad1268e8e4f2556fbede97b
https://hal-pasteur.archives-ouvertes.fr/pasteur-04117002
https://hal-pasteur.archives-ouvertes.fr/pasteur-04117002
Autor:
Sarah E. Silk, Wilmina F. Kalinga, Ivanny M. Mtaka, Nasoro S. Lilolime, Maximillian Mpina, Florence Milando, Saumu Ahmed, Ababacar Diouf, Fatuma Mkwepu, Beatus Simon, Thabit Athumani, Mohammed Rashid, Latipha Mohammed, Omary Lweno, Ali M. Ali, Gloria Nyaulingo, Bakari Mwalimu, Sarah Mswata, Tunu G. Mwamlima, Jordan R. Barrett, Lawrence T. Wang, Yrene Themistocleous, Lloyd D. W. King, Susanne H. Hodgson, Ruth O. Payne, Carolyn M. Nielsen, Alison M. Lawrie, Fay L. Nugent, Jee-Sun Cho, Carole A. Long, Kazutoyo Miura, Simon J. Draper, Angela M. Minassian, Ally I. Olotu
BackgroundRH5 is the leading blood-stage candidate antigen for inclusion in aPlasmodium falciparummalaria vaccine, however, its safety profile and ability to induce functional immune responses in a malaria-endemic population are unknown. Characterisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a74608ba837dc9e18097bb4d2468645f
https://doi.org/10.1101/2023.04.17.23288686
https://doi.org/10.1101/2023.04.17.23288686
Autor:
Mimi M, Hou, Jordan R, Barrett, Yrene, Themistocleous, Thomas A, Rawlinson, Ababacar, Diouf, Francisco J, Martinez, Carolyn M, Nielsen, Amelia M, Lias, Lloyd D W, King, Nick J, Edwards, Nicola M, Greenwood, Lucy, Kingham, Ian D, Poulton, Baktash, Khozoee, Cyndi, Goh, Dylan J, Mac Lochlainn, Jo, Salkeld, Micheline, Guilotte-Blisnick, Christèle, Huon, Franziska, Mohring, Jenny M, Reimer, Virander S, Chauhan, Paushali, Mukherjee, Sumi, Biswas, Iona J, Taylor, Alison M, Lawrie, Jee-Sun, Cho, Fay L, Nugent, Carole A, Long, Robert W, Moon, Kazutoyo, Miura, Sarah E, Silk, Chetan E, Chitnis, Angela M, Minassian, Simon J, Draper
Publikováno v:
medRxiv : the preprint server for health sciences.
There are no licensed vaccines againstWe conducted two Phase I/IIa clinical trials to assess the safety, immunogenicity and efficacy of two vaccines targeting region II ofThirty-two volunteers were enrolled and vaccinated (n=16 for each vaccine). No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af9a53b92d9028ac090fcdc36e9f1a39
https://pubmed.ncbi.nlm.nih.gov/35664997
https://pubmed.ncbi.nlm.nih.gov/35664997
Autor:
Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Lloyd D W King, Lea K Barfod, Simon J Draper, Ivan Campeotto, Matthew K Higgins
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2539-2559 (2024)
Abstract There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and parasite transmission. Antibodies which target PfRH5 are hi
Externí odkaz:
https://doaj.org/article/b942500814154714b2e7a3f058d0d828