Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lloyd D. Ralph"'
Autor:
Habberfield Alan D, Kathleen Jensen-Pippo, Lloyd D. Ralph, Steven William Westwood, Gregory John Russell-Jones
Publikováno v:
International Journal of Pharmaceutics. 145:1-8
Proteins are normally very poorly absorbed from the intestine as the intestinal epithelial cells act as a barrier to the uptake of all but the smallest of molecules. We have used the natural uptake mechanism for Vitamin B 12 (VB 12 ) to increase the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c51c88eaa95188b415d264c43a5df3
https://doi.org/10.1016/s0378-5173(96)04690-x
https://doi.org/10.1016/s0378-5173(96)04690-x
Publikováno v:
Pharmaceutical Research. 13:102-107
Purpose. The focus of this paper is to demonstrate that pegylation of a therapeutic protein, recombinant human granulocyte colony stimulating factor (PEG-G-CSF), results in an increase in stability and in retention of in vivo bioactivity when adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e73e9857d371c94a05b694643ad32d9e
https://doi.org/10.1023/a:1016089503186
https://doi.org/10.1023/a:1016089503186
Autor:
Melissa A Woodward, David C. Litzinger, Ralph W. Niven, Wendy Laderach, K Lane Whitcomb, Lloyd D. Ralph, Michael J. Treuheit, Charles M. Ransone
Publikováno v:
Journal of Immunological Methods. 187:151-161
The chelating agent diethylenetriaminepentaacetic acid (DTPA) has been conjugated site-specifically to the N-terminus of recombinant human interleukin-2 (rhIL-2) by reaction with DTPA dianhydride at an initial pH of 6.0, thus demonstrating broader ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195a9737e840df13b58302c6294b3d6f
https://doi.org/10.1016/0022-1759(95)00179-e
https://doi.org/10.1016/0022-1759(95)00179-e
Autor:
John Wilson, Habberfield Alan D, Ralph W. Niven, Linda Shaner, Lloyd D. Ralph, K Lane Whitcomb
Publikováno v:
Journal of Controlled Release. 32:177-189
The pulmonary delivery of recombinant human granulocyte — colony stimulating factor (rhG-CSF, 18.8kDa) and two polyethelene glycol (PEG) conjugates of rhG-CSF, (P1, 81.5 kDa and P2, 146.8 kDa) was investigated in the rat. Doses of 50 and 500 μg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d830aff639401b8e1c52e928ab85d43
https://doi.org/10.1016/0168-3659(94)90056-6
https://doi.org/10.1016/0168-3659(94)90056-6
Autor:
Scott L. Lauren, Lloyd D. Ralph, Charles M. Ransone, Viswanatham Katta, Michael J. Treuheit, David C. Litzinger
Publikováno v:
Biochemistry. 34(14)
The chelating agent diethylenetriaminepentaacetic acid (DTPA) was conjugated site-specifically to the N-terminus of recombinant human granulocyte-colony-stimulating factor (rhG-CSF) by reaction of the protein with DTPA dianhydride at an initial pH of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e24b877f9e67acb15718dcde6cd629
https://pubmed.ncbi.nlm.nih.gov/7536471
https://pubmed.ncbi.nlm.nih.gov/7536471