Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Lloyd D Fricker"'
Autor:
Javier Garcia-Pardo, Sebastian Tanco, Lucía Díaz, Sayani Dasgupta, Juan Fernandez-Recio, Julia Lorenzo, Francesc X Aviles, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187778 (2017)
Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways. Unlike other members of the metallocarboxypeptidase family, CPD is a multicatalytic enzy
Externí odkaz:
https://doaj.org/article/ebd36402d1ea45609c3f3355a16f7341
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152905 (2016)
Carboxypeptidase A6 (CPA6) is an extracellular matrix metallocarboxypeptidase that modulates peptide and protein function by removal of hydrophobic C-terminal amino acids. Mutations in the human CPA6 gene that reduce enzymatic activity in the extrace
Externí odkaz:
https://doaj.org/article/87da2a20d5134553a816948a0270a596
Autor:
Sayani Dasgupta, Ciyu Yang, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Robyn D Moir, Ian M Willis, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163312 (2016)
Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples. In the present study, we used a qua
Externí odkaz:
https://doaj.org/article/963777c8a9844402ae8af96bb042329c
Autor:
Sayani Dasgupta, Michael A Fishman, Hana Mahallati, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145333 (2015)
Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal neurons. Although many theories
Externí odkaz:
https://doaj.org/article/485f4f8a08234278ba9c7ce9dbb9178d
Autor:
Matthew R Sapio, Monique Vessaz, Pierre Thomas, Pierre Genton, Lloyd D Fricker, Annick Salzmann
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123180 (2015)
Carboxypeptidase A6 (CPA6) is a peptidase that removes C-terminal hydrophobic amino acids from peptides and proteins. The CPA6 gene is expressed in the brains of humans and animals, with high levels of expression during development. It is translated
Externí odkaz:
https://doaj.org/article/e17191d978614dd0b98df9c17b0db0d9
Autor:
Sayani Dasgupta, Leandro M Castro, Russell Dulman, Ciyu Yang, Marion Schmidt, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103604 (2014)
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracell
Externí odkaz:
https://doaj.org/article/a25220dad1ee422eb2cbd282a3f07f1c
Autor:
Jonathan H Wardman, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104232 (2014)
ProSAAS is the precursor for some of the most abundant peptides found in mouse brain and other tissues, including peptides named SAAS, PEN, and LEN. Both SAAS and LEN are found in big and little forms due to differential processing. Initial processin
Externí odkaz:
https://doaj.org/article/03c40f7f5e6d4b95a79e427babda5e85
Autor:
Iryna Berezniuk, Juan J Sironi, Jonathan Wardman, Raymond C Pasek, Nicolas F Berbari, Bradley K Yoder, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60981 (2013)
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation. Previously, elevated levels of peptides derived from cy
Externí odkaz:
https://doaj.org/article/c4248ff8dab04f3297ae00a74b8414f5
Autor:
Julia S Gelman, Juan Sironi, Iryna Berezniuk, Sayani Dasgupta, Leandro M Castro, Fabio C Gozzo, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53263 (2013)
Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 subunits. While the impact of bortezomib on protein stability is known, the effect of this drug on intracellular peptides has not been previously explored. A qua
Externí odkaz:
https://doaj.org/article/1f7ffa509fdd4f1c90b0b1001dcb0b75
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28152 (2011)
ProSAAS is the precursor of a number of peptides that have been proposed to function as neuropeptides. Because proSAAS mRNA is highly expressed in the arcuate nucleus of the hypothalamus, we examined the cellular localization of several proSAAS-deriv
Externí odkaz:
https://doaj.org/article/a4285e03b3364d418f9fa6a2cb1a65b1