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Akademický článek

MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1

Autor: Rongfeng LIU, Lingling ZHANG, Zhihong XU, Yanzhi CUI

Publikováno v: Chinese Journal of Lung Cancer, Vol 23, Iss 4, Pp 223-232 (2020)

Background and objective MicroRNAs (miRNAs) are non-coding small molecule RNAs that are widely found in eukaryotic organisms, although some miRNAs have been found in tumors, the expression and effects of miR-665 on small cell lung cancer (SCLC) are u

Externí odkaz: https://doaj.org/article/8845303656a04e1ba089742260310df5

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Akademický článek

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration

Autor: Greenwood, Erin, Maisel, Sabrina, Ebertz, David, Russ, Atlantis, Pandey, Ritu, Schroeder, Joyce

We have previously demonstrated that Llgl1 loss results in a gain of mesenchymal phenotypes and a loss of apicobasal and planar polarity. We now demonstrate that these changes represent a fundamental shift in cellular phenotype. Llgl1 regulates the e

Externí odkaz: http://hdl.handle.net/10150/622116
http://arizona.openrepository.com/arizona/handle/10150/622116

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miR-665通过靶向调控LLGL1促进小细胞肺癌生物学行为的研究

Publikováno v: Chinese Journal of Lung Cancer

MicroRNAs (miRNAs) are non-coding small molecule RNAs that are widely found in eukaryotic organisms, although some miRNAs have been found in tumors, the expression and effects of miR-665 on small cell lung cancer (SCLC) are unclear. The aim of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff853cebb4d710c382693d521c2df8dc
http://europepmc.org/articles/PMC7210082

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LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal AdenocarcinomaSummary

Autor: Yangchao Chen, Tian Xia, Guolin Li, Frederic Khe Cheong Fung, Ka Fai To, Joanna H.M. Tong, Chi Han Li, Yin-Xin Zhu, Chi Hin Wong, Huiyi Feng, Rufu Chen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 811-828 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Gemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict the gemcitabine response of patients and enhance gemcitabine chemosensitivity are important to improve pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522e00f260ff434833ed2e958f307cb5
http://www.sciencedirect.com/science/article/pii/S2352345X20300989

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Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

Autor: Alexander Gont, Danny Jomaa, Karen Jardine, Ian A. J. Lorimer, Sylvie J. Lavictoire, David P. Cook

Publikováno v: The Journal of Biological Chemistry

The protein Lgl1 is a key regulator of cell polarity. We previously showed that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN tumour suppressor loss and aberrant activation of the PI 3-kinase pathway; this contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eac172f9342d10d751e70e28529ec91
http://europepmc.org/articles/PMC8551657

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A 21-bp indel within the LLGL1 gene is significantly associated with litter size in goat

Autor: Mingyue Chen, Chuanying Pan, Xiaoyue Song, Nuan Liu, Wenbo Cui, Xuelian Zhang

Publikováno v: Animal Biotechnology. 32:213-218

The scribble cell polarity complex component (LLGL1) is part of the cytoskeletal network and is involved in maintaining cell polarity and epithelial integrity. Based on the whole-genome sequencing ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff74ac3ce5bf6801dc60d2554409dbae
https://doi.org/10.1080/10495398.2019.1677682

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Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration

Autor: Atlantis Dawn Russ, Sabrina Maisel, Erin Greenwood, David Ebertz, Joyce A. Schroeder, Ritu Pandey

Publikováno v: Oncotarget

// Erin Greenwood 1 , Sabrina Maisel 2,5,* , David Ebertz 1,* , Atlantis Russ 1,4 , Ritu Pandey 2,6 and Joyce Schroeder 1,2,3,4,5 1 Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 2 Arizona Cancer Center, Universi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c20c5a69ac61bdfaea7849596d58fa
https://doi.org/10.18632/oncotarget.11320

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