Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Llewellyn, KJ"'
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Myogenic differentiation of VCP disease induced pluripotent stem cells: A novel platform for drug discovery
Autor: Llewellyn, KJ, Nalbandian, A, Weiss, LN, Chang, I, Yu, H, Khatib, B, Tan, B, Scarfone, V, Kimonis, VE
Publikováno v: Llewellyn, KJ; Nalbandian, A; Weiss, LN; Chang, I; Yu, H; Khatib, B; et al.(2017). Myogenic differentiation of VCP disease induced pluripotent stem cells: A novel platform for drug discovery. PLOS ONE, 12(6). doi: 10.1371/journal.pone.0176919. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/10r3f9vv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::847dfda2baa7fc4191d6373aa80eb831
http://www.escholarship.org/uc/item/10r3f9vv
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2
A progressive translational mouse model of human valosin-containing protein disease: The VCPR155H/+mouse
Autor: Nalbandian, A, Llewellyn, KJ, Badadani, M, Yin, HZ, Nguyen, C, Katheria, V, Watts, G, Mukherjee, J, Vesa, J, Caiozzo, V, Mozaffar, T, Weiss, JH, Kimonis, VE
Publikováno v: Nalbandian, A; Llewellyn, KJ; Badadani, M; Yin, HZ; Nguyen, C; Katheria, V; et al.(2013). A progressive translational mouse model of human valosin-containing protein disease: The VCPR155H/+mouse. Muscle and Nerve, 47(2), 260-270. doi: 10.1002/mus.23522. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6fv693w5
Introduction: Mutations in the valosin-containing protein (VCP) gene cause hereditary inclusion body myopathy (IBM) associated with Paget disease of bone (PDB), and frontotemporal dementia (FTD). More recently, these mutations have been linked to 2%
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c9520552e3ef636047637174141db719
http://www.escholarship.org/uc/item/6fv693w5
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4
Akademický článek
Concurrent Appendicitis and Meckel's Diverticulitis Presenting With Small Bowel Obstruction in an Adult: A Case Report.
Autor: Llewellyn KJ; General Surgery, Corewell Health Farmington Hills, Farmington Hills, USA., Knaggs M; General Surgery, Corewell Health Farmington Hills, Farmington Hills, USA., Serena T; General Surgery, Corewell Health Farmington Hills, Farmington Hills, USA., Gerken JR; General Surgery, Corewell Health Farmington Hills, Farmington Hills, USA.
Publikováno v: Cureus [Cureus] 2024 Aug 16; Vol. 16 (8), pp. e67000. Date of Electronic Publication: 2024 Aug 16 (Print Publication: 2024).
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5
Akademický článek
Myogenic differentiation of VCP disease-induced pluripotent stem cells: A novel platform for drug discovery.
Autor: Llewellyn KJ; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America.; Sue and Bill Gross Stem Cell Research Center, University of California-Irvine School of Medicine, Irvine, California, United States of America., Nalbandian A; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America.; Sue and Bill Gross Stem Cell Research Center, University of California-Irvine School of Medicine, Irvine, California, United States of America., Weiss LN; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America.; Sue and Bill Gross Stem Cell Research Center, University of California-Irvine School of Medicine, Irvine, California, United States of America., Chang I; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America., Yu H; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America., Khatib B; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America.; Sue and Bill Gross Stem Cell Research Center, University of California-Irvine School of Medicine, Irvine, California, United States of America., Tan B; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America., Scarfone V; Sue and Bill Gross Stem Cell Research Center, University of California-Irvine School of Medicine, Irvine, California, United States of America., Kimonis VE; Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California-Irvine School of Medicine, Irvine, California, United States of America.; Sue and Bill Gross Stem Cell Research Center, University of California-Irvine School of Medicine, Irvine, California, United States of America.
Publikováno v: PloS one [PLoS One] 2017 Jun 02; Vol. 12 (6), pp. e0176919. Date of Electronic Publication: 2017 Jun 02 (Print Publication: 2017).
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6
Akademický článek
Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.
Autor: Nalbandian A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. a.nalbandian@uci.edu.; Division of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA. a.nalbandian@uci.edu.; Division of Genetics and Metabolism, Department of Pediatrics, University of California Irvine, Irvine, CA, USA. a.nalbandian@uci.edu., Khan AA; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA., Srivastava R; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA., Llewellyn KJ; Division of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA., Tan B; Division of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA., Shukr N; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA., Fazli Y; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA., Kimonis VE; Division of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA., BenMohamed L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. lbenmoha@uci.edu.; Department of Molecular Biology and Biochemistry, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. lbenmoha@uci.edu.; Institute for Immunology, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. lbenmoha@uci.edu.
Publikováno v: Inflammation [Inflammation] 2017 Feb; Vol. 40 (1), pp. 21-41.
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7
Akademický článek
A Fine Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem Proteinopathy.
Autor: Llewellyn KJ; Department of Pediatrics, Division of Genetics and Genomics Medicine, University of California Irvine, Irvine, CA, 92697, United States of America; Sue and Bill Gross Stem Institute, University of California Irvine, Irvine, CA, 92697, United States of America., Walker N; Department of Pediatrics, Division of Genetics and Genomics Medicine, University of California Irvine, Irvine, CA, 92697, United States of America., Nguyen C; Department of Pediatrics, Division of Genetics and Genomics Medicine, University of California Irvine, Irvine, CA, 92697, United States of America., Tan B; Department of Pediatrics, Division of Genetics and Genomics Medicine, University of California Irvine, Irvine, CA, 92697, United States of America., BenMohamed L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697, United States of America; Institute for Immunology, University of California Irvine, School of Medicine, Irvine, CA, 92697, United States of America., Kimonis VE; Department of Pediatrics, Division of Genetics and Genomics Medicine, University of California Irvine, Irvine, CA, 92697, United States of America; Sue and Bill Gross Stem Institute, University of California Irvine, Irvine, CA, 92697, United States of America., Nalbandian A; Department of Pediatrics, Division of Genetics and Genomics Medicine, University of California Irvine, Irvine, CA, 92697, United States of America; Sue and Bill Gross Stem Institute, University of California Irvine, Irvine, CA, 92697, United States of America.
Publikováno v: PloS one [PLoS One] 2015 Jul 02; Vol. 10 (7), pp. e0131995. Date of Electronic Publication: 2015 Jul 02 (Print Publication: 2015).
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8
Akademický článek
In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics.
Autor: Nalbandian A; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: a.nalbandian@uci.edu., Llewellyn KJ; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA., Gomez A; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA., Walker N; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA., Su H; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA., Dunnigan A; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA., Chwa M; Department of Ophthalmology, Gavin Herbert Eye Institute, University of California-Irvine, Irvine, CA 92697, USA., Vesa J; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA., Kenney MC; Department of Ophthalmology, Gavin Herbert Eye Institute, University of California-Irvine, Irvine, CA 92697, USA; Department of Pathology and Laboratory Medicine, University of California- Irvine, Irvine, CA 92697, USA., Kimonis VE; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: vkimonis@uci.edu.
Publikováno v: Mitochondrion [Mitochondrion] 2015 May; Vol. 22, pp. 1-8. Date of Electronic Publication: 2015 Feb 25.
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9
Akademický článek
Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy.
Autor: Nalbandian A; Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California, United States of America; Sue and Bill Gross Stem Cell Center, University of California, Irvine, California, United States of America., Llewellyn KJ; Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California, United States of America; Sue and Bill Gross Stem Cell Center, University of California, Irvine, California, United States of America., Nguyen C; Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California, United States of America., Yazdi PG; Sue and Bill Gross Stem Cell Center, University of California, Irvine, California, United States of America; Systomic Health LLC, Los Angeles, California, United States of America., Kimonis VE; Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California, United States of America; Sue and Bill Gross Stem Cell Center, University of California, Irvine, California, United States of America.
Publikováno v: PloS one [PLoS One] 2015 Apr 17; Vol. 10 (4), pp. e0122888. Date of Electronic Publication: 2015 Apr 17 (Print Publication: 2015).
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10
Akademický článek
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Autor: Llewellyn KJ; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: kllewell@uci.edu., Nalbandian A; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA., Gomez A; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA., Wei D; Department of Anatomy & Neurobiology, Gillespie Hall, University of California-Irvine, Irvine, CA 92697, USA., Walker N; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA., Kimonis VE; Department of Pediatrics, Division of Genetics and Genomics, 2501 Hewitt Hall, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: vkimonis@uci.edu.
Publikováno v: Neurobiology of disease [Neurobiol Dis] 2015 Apr; Vol. 76, pp. 77-86. Date of Electronic Publication: 2015 Feb 12.
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