Bat Red Blood Cells express Nucleic Acid Sensing Receptors and bind RNA and DNA

Autor: LK Metthew Lam, Jane Dobkin, Kaitlyn A. Eckart, Ian Gereg, Andrew DiSalvo, Amber Nolder, Eman Anis, Julie C. Ellis, Greg Turner, Nilam S. Mangalmurti

Red blood cells (RBCs) demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. Here we show that bat RBCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c0f8ca0197cf1380dced9c5f2a289ee
https://doi.org/10.1101/2022.01.13.476238

RAGE interacts with the necroptotic protein RIPK3 and mediates transfusion-induced danger signal release

Autor: Nilam S. Mangalmurti, Meghan J. Hotz, Danielle Qing, Lk Metthew Lam, Hilary Faust

Publikováno v: Vox Sang

RBC transfusion is associated with increased morbidity and mortality in critically ill patients. Endothelial cell necroptosis and subsequent damage-associated molecular pattern (DAMP) release has been identified as a mechanism of injury following RBC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da91ca316473ef36b587a3d7954824f7
https://europepmc.org/articles/PMC8215843/

A first look at the protective immunity elicited by the yellow fever virus 17D live-attenuated vaccine (VIR7P.1051)

Autor: Alan Watson, LK Metthew Lam, Christina Gardner, William Klimstra, Kate Ryman

Publikováno v: The Journal of Immunology. 192:208.3-208.3

A hallmark of anti-viral vaccination for 77 years has been the safe and effective live-attenuated 17D yellow fever virus (YFV) vaccines. Among more than 500 million individuals vaccinated, only five cases of yellow fever have been reported. This effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::211b7321cbcd90ca21dec4b6e66182e5
https://doi.org/10.4049/jimmunol.192.supp.208.3

Human red blood cells express the RNA sensor TLR7.

Autor: Metthew Lam LK; Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Oatman E; Division of Traumatology, Surgical Critical Care, and Emergency Surgical Services, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Eckart KA; Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Klingensmith NJ; Division of Traumatology, Surgical Critical Care, and Emergency Surgical Services, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Flowers E; Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Sayegh L; Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Yuen J; Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Clements RL; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Meyer NJ; Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Jurado KA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Vaughan AE; Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 19104, USA., Eisenbarth SC; Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Mangalmurti NS; Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. nspatel@pennmedicine.upenn.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jul 09; Vol. 14 (1), pp. 15789. Date of Electronic Publication: 2024 Jul 09.

Biochemical characterization of ethanol-dependent reduction of furfural by alcohol dehydrogenases.

Autor: Li Q; School of Molecular Biosciences, Washington State University, Life Sciences Building, Room 202, 100 Dairy Road, Pullman, WA 99164-7520, USA., Metthew Lam LK, Xun L

Publikováno v: Biodegradation [Biodegradation] 2011 Nov; Vol. 22 (6), pp. 1227-37. Date of Electronic Publication: 2011 Apr 28.