Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Ljungars A"'
Autor:
Melisa Benard-Valle, Yessica Wouters, Anne Ljungars, Giang Thi Tuyet Nguyen, Shirin Ahmadi, Tasja Wainani Ebersole, Camilla Holst Dahl, Alid Guadarrama-Martínez, Frederikke Jeppesen, Helena Eriksen, Gibran Rodríguez-Barrera, Kim Boddum, Timothy Patrick Jenkins, Sara Petersen Bjørn, Sanne Schoffelen, Bjørn Gunnar Voldborg, Alejandro Alagón, Andreas Hougaard Laustsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions of similar and dissimilar antigens, making them versatile tools for the treatment of e.g., infectious diseases and animal envenomations. However, the
Externí odkaz:
https://doaj.org/article/04f4672b78aa4539b3bb04b0b225a5df
Autor:
Tulika, Tulika, Ruso-Julve, Fulgencio, Ahmadi, Shirin, Ljungars, Anne, Rivera-de-Torre, Esperanza, Wade, Jack, Fernández-Quintero, Monica L., Jenkins, Timothy P., Belfakir, Selma B., Ross, Georgina M.S., Boyens-Thiele, Lars, Buell, Alexander K., Sakya, Siri A., Sørensen, Christoffer V., Bohn, Markus-Frederik, Ledsgaard, Line, Voldborg, Bjørn G., Francavilla, Chiara, Schlothauer, Tilman, Lomonte, Bruno, Andersen, Jan Terje, Laustsen, Andreas H.
Publikováno v:
In Structure 5 September 2024 32(9):1404-1418
Autor:
Christoffer V. Sørensen, Julián Fernández, Anna Christina Adams, Helen H. K. Wildenauer, Sanne Schoffelen, Line Ledsgaard, Manuela B. Pucca, Michael Fiebig, Felipe A. Cerni, Tulika Tulika, Bjørn G. Voldborg, Aneesh Karatt-Vellatt, J. Preben Morth, Anne Ljungars, Lise M. Grav, Bruno Lomonte, Andreas H. Laustsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclini
Externí odkaz:
https://doaj.org/article/99301d927d1f464bb9fbaf12412f986c
Autor:
Christoffer V. Sørensen, Line Ledsgaard, Helen H. K. Wildenauer, Camilla H. Dahl, Tasja W. Ebersole, Markus-Frederik Bohn, Anne Ljungars, Timothy P. Jenkins, Andreas H. Laustsen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Antibodies with cross-reactive binding and broad toxin-neutralizing capabilities are advantageous for treating indications such as infectious diseases and animal envenomings. Such antibodies have been successfully selected against closely re
Externí odkaz:
https://doaj.org/article/dc0f626d0f1e4380a0b1f8a7a0308d17
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023)
Abstract Snakebite envenoming is a significant global health challenge, and for over a century, traditional plasma-derived antivenoms from hyperimmunized animals have been the primary treatment against this infliction. However, these antivenoms have
Externí odkaz:
https://doaj.org/article/44dd0191766d4bb287cb302dcc0846fd
Autor:
Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty, Andreas H. Laustsen
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBeyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug development process can save resources and avoid costly late-stage failures. Here, we review
Externí odkaz:
https://doaj.org/article/40e1d35a06264ee9a178e72c2e9b24b1
Akademický článek
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Autor:
Line Ledsgaard, Jack Wade, Timothy P. Jenkins, Kim Boddum, Irina Oganesyan, Julian A. Harrison, Pedro Villar, Rachael A. Leah, Renato Zenobi, Sanne Schoffelen, Bjørn Voldborg, Anne Ljungars, John McCafferty, Bruno Lomonte, José M. Gutiérrez, Andreas H. Laustsen, Aneesh Karatt-Vellatt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The treatment of snakebite envenoming is currently suboptimal. Existing antivenoms often lack efficacy and may cause adverse reactions. Here, the authors derive, develop, and demonstrate the utility of toxin-specific broadly-neutralizing human monocl
Externí odkaz:
https://doaj.org/article/e25513bb2bca42949088d83d90b24bca
Autor:
Moore, Catherine M., Ljungars, Anne, Paul, Matthew J., Dahl, Camilla Holst, Ahmadi, Shirin, Adams, Anna Christina, Grav, Lise Marie, Schoffelen, Sanne, Voldborg, Bjørn Gunnar, Laustsen, Andreas Hougaard, Ma, Julian K-C
Publikováno v:
In Toxicon July 2023
Autor:
Shirin Ahmadi, Melisa Benard-Valle, Kim Boddum, Fernanda C. Cardoso, Glenn F. King, Andreas Hougaard Laustsen, Anne Ljungars
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Ion channels play a crucial role in diverse physiological processes, including neurotransmission and muscle contraction. Venomous creatures exploit the vital function of ion channels by producing toxins in their venoms that specifically target these
Externí odkaz:
https://doaj.org/article/0fdee07fa94244deb089186a6d8f2735